Qi (Tony) Zhou

Photo
Assistant Professor, Industrial and Physical Pharmacy
Phone:
765-496-0707
Fax:
765-494-6545
Specialization: pharmaceutical manufacturing of solid dosage forms, particle engineering, powder technology, surface characterization of pharmaceutical solids, inhalation formulation, pulmonary drug delivery system, dry powder inhaler

Education

2013-2015 NHMRC Early Career Fellow (=NIH K01), University of Sydney, Australia
2012-2013 Postdoctoral Research Fellow, University of Sydney, Australia
2011-2012 Postdoctoral Research Fellow, Monash University, Australia
2007-2011 PhD in Pharmacy, Monash University, Australia
2004-2008 MSc in Pharmacy, National University of Singapore, Singapore
1997-2001 BEng in Pharmaceutics, Shenyang Pharmaceutical University, China

Research

Dr. Zhou’s research focuses on: (1) particle engineering for innovative pharmaceutical manufacturing of solid dosage forms; (2) advanced characterization of pharmaceutical solids; (3) novel formulation design for pulmonary drug delivery systems.

 

 

Education

2013-2015 NHMRC Early Career Fellow (=NIH K01), University of Sydney, Australia
2012-2013 Postdoctoral Research Fellow, University of Sydney, Australia
2011-2012 Postdoctoral Research Fellow, Monash University, Australia
2007-2011 PhD in Pharmacy, Monash University, Australia
2004-2008 MSc in Pharmacy, National University of Singapore, Singapore
1997-2001 BEng in Pharmaceutics, Shenyang Pharmaceutical University, China

 

Research

Our research focuses on: (1) particle engineering for innovative pharmaceutical manufacturing of solid dosage forms; (2) advanced characterization of pharmaceutical solids; (3) novel formulation design for pulmonary drug delivery systems.

(1) Innovation is in great demand for pharmaceutical manufacturing aiming to improve the production efficiency of traditional small-molecule pharmaceutical products and to design suitable formulation for new biopharmaceutical entities. Our research is to apply novel particle engineering techniques such as spray drying and dry coating to design efficient manufacture process for solid dosage forms of both small- and large-molecule pharmaceuticals. 

(2) Characterization of solid surface properties is critical to ensure the manufacturability, stability and formulation performance of pharmaceutical solid dosage forms. Our research has developed an advanced surface characterization platform to achieve fundamental understanding in the impact of material surface properties on the formulation performance, including effect of surface composition on stability of amorphous solid dispersions and influence of surface properties on aerosol performance of dry powder inhalers.    

(3) Inhalation products become popular for treatment of pulmonary diseases because they can deliver the therapeutics directly to the site of diseases with potentially minimized systemic side effects and maximized treatment efficacy. Dr Zhou’s research is to design smart inhalation formulations for improved treatment of critical pulmonary diseases such as asthma, COPD and lung infection.  

Lab Members

Sonal V. Bhujbal (Graduate Student with Dr. Tony Zhou)
Guihong Chai (Post-Doctoral Research Associate with Dr. Qi "Tony" Zhou)
Tarun Mutukuri (Graduate Student)
Heejun Park (Post-Doctoral Research Assistant with Dr. Tony Zhou)
Nivedita J. Shetty (Graduate Student with Dr. Tony Zhou)
Nathan E. Wilson (Graduate Student with Dr. Tony Zhou)
Shihui Yu (Visiting Scholar with Dr. Tony Zhou)
Chune Zhu (Visiting Scholar with Dr. Zhou)

Honors and Credentials

2017        Showalter Trust Research Award, Ralph W. and Grace M. Showalter Research Trust

2017        New Investigator Award, International Society of Aerosols in Medicines (ISAM)

2016        Emerging Researcher Award, International Pharmaceutical Excipients Council of the Americas Foundation (IPEC)

2015        Postdoctoral Fellow Award, American Association of Pharmaceutical Scientists (AAPS)

2014        Australian Endeavor Fellowship, Australian Government

2013        Australian Biomedical Early Career Fellowship (= NIH K01), NHMRC

2012        Outstanding Graduate Student Research Award in Pharmaceutical Technologies, AAPS

2011        Postgraduate Publications Award, Monash University 

2010        Excipients Graduate Student Award, International Pharmaceutical Excipients Council of the Americas Foundation (IPEC) 

Representative Publications

Full publication list: https://scholar.google.com/citations?user=KrwU6bQAAAAJ&hl=en

Lin, Y. , Zhou, Q.T. , Han M., Onufrak, N.J., Chen K., Wang, J., Forrest, A., Chan, H., Li, J. Mechanism-based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy. Accepted December 13th 2017.

Lin, Y., Zhou, Q.T., Hu, Y., Onufrak, N.J., Sun, S., Wang, J., Forrest, A., Chan, H., Li, J. 2017. Pulmonary Pharmacokinetics of Colistin Following Administration of Dry Powder Aerosols in Rats. Antimicrobial Agents and Chemotherapy. 61 (11), e00973-17. (Co-first authors.)

Li, L., Leung, S.S.Y., Gengenbach, T., Yu, J., Gao, G.F., Tang, P., Zhou, Q.T., Chan, H.K. 2017, Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation. International Journal of Pharmaceutics, 530(1-2), 30-39.

Lin, Y., Zhou, Q.T., Onufrak, N.J., Wirth, V., Chen, K., Forrest, A., Wang, J., Chan, H., Li, J. 2017, Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic/Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy, 61(8), e00211-17.

Wei G., Mangal, S., Denman J., Gengenbach, T., Bonar, K.L., Khan, R. I., Qu, L., Li, T., Zhou, Q.T. * 2017, Effects of coating materials and processing conditions on flow enhancement of cohesive acetaminophen powders by high-shear processing with pharmaceutical lubricants. Journal of Pharmaceutical Sciences, 106(10) 3022-3032.  

Ahmed, M., Velkov, T., Lin, Y., Yun, B., Nowell, C., Zhou, F., Zhou, Q., Chan, H., Azad, M., Li, L. 2017, Potential toxicity of polymyxins in human lung epithelial cells. Antimicrobial Agents and Chemotherapy, 61(6), e02690-16.

Nie, H., Byrn, S., Zhou, Q.T.* Stability of pharmaceutical salts in solid oral dosage forms. 2017, Drug Development and Industrial Pharmacy, 43(8), 1215-1228.  (Top ten most downloaded paper in 2017)

Mangal, S., Gao, W., Li, T., Zhou, Q.T.* Nanoparticle chemotherapy via pulmonary delivery for treatment of lung cancers: Challenges and opportunities. 2017, Acta Pharmacologica Sinica, 38, 782-797.  

Lin, Y, Zhou, Q.T.*, Cheah, S., Zhao, J., Chen, K., Wang, J., Chan, H.*, Li, J. Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model. 2017, Antimicrobial Agents and Chemotherapy, 61(3), e02025-16.

Qu, L., Stewart, P.J., Hapgood, K., Satu Lakio, Morton, D.A.V.*, Zhou, Q.T.* Single-step co-processing of cohesive powder via mechanical dry coating for direct tablet compression. 2017, Journal of Pharmaceutical Sciences, 106(1), 159–167.

Lin, Y. , Zhou, Q.T. , Han M., Onufrak, N.J., Chen K., Wang, J., Forrest, A., Chan, H., Li, J. Mechanism-based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy. Accepted December 13th 2017. #

Lin, Y., Zhou, Q.T., Han M., Chen K., Onufrak, N.J., Wang, J., Howden, B., Turnidge J., Forrest, A., Chan, H., Li, J. Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy. Accepted December 4th 2017. #

Moussa, E.M., Wilson, N., Zhou, Q.T., Singh, S.K., Nema, S., Topp, E.M. Effects of the drying process on an IgG1 monoclonal antibody using solid-state hydrogen deuterium exchange with mass spectrometric analysis (ssHDX-MS). Pharmaceutical Research. Accepted November 21st 2017. #

Shetty, N., Zeng, L., Mangal, S., Nie, H., Rowles, M.R., Guo, R., Han, Y., Park, J., Zhou, Q.T.* Effects of Moisture-induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations. Pharmaceutical Research. Accepted October 13th 2017. #

Lin, Y., Zhou, Q.T., Hu, Y., Onufrak, N.J., Sun, S., Wang, J., Forrest, A., Chan, H., Li, J. Pulmonary Pharmacokinetics of Colistin Following Administration of Dry Powder Aerosols in Rats. Antimicrobial Agents and Chemotherapy. Accepted August 6th 2017. #

Li, L., Leung, S.S.Y., Gengenbach, T., Yu, J., Gao, G.F., Tang, P., Zhou, Q.T., Chan, H.K. 2017, Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation. International Journal of Pharmaceutics, 530(1-2), 30-39. #

Lin, Y., Zhou, Q.T., Onufrak, N.J., Wirth, V., Chen, K., Forrest, A., Wang, J., Chan, H., Li, J. 2017, Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic/Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy, 61(8), e00211-17. #

Wei G., Mangal, S., Denman J., Gengenbach, T., Bonar, K.L., Khan, R. I., Qu, L., Li, T., Zhou, Q.T. * 2017, Effects of coating materials and processing conditions on flow enhancement of cohesive acetaminophen powders by high-shear processing with pharmaceutical lubricants. Journal of Pharmaceutical Sciences, 106(10) 3022-3032. #

Ahmed, M., Velkov, T., Lin, Y., Yun, B., Nowell, C., Zhou, F., Zhou, Q., Chan, H., Azad, M., Li, L. 2017, Potential toxicity of polymyxins in human lung epithelial cells. Antimicrobial Agents and Chemotherapy, 61(6), e02690-16. #

 Nie, H., Byrn, S., Zhou, Q.T.* Stability of pharmaceutical salts in solid oral dosage forms. 2017, Drug Development and Industrial Pharmacy, 43(8), 1215-1228. # (Top ten most downloaded paper of the journal in 2017)

Mangal, S., Gao, W., Li, T., Zhou, Q.T.* Nanoparticle chemotherapy via pulmonary delivery for treatment of lung cancers: Challenges and opportunities. 2017, Acta Pharmacologica Sinica, 38, 782-797. # 

Lin, Y, Zhou, Q.T.*, Cheah, S., Zhao, J., Chen, K., Wang, J., Chan, H.*, Li, J. Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model. 2017, Antimicrobial Agents and Chemotherapy, 61(3), e02025-16. #

Qu, L., Stewart, P.J., Hapgood, K., Satu Lakio, Morton, D.A.V.*, Zhou, Q.T.* Single-step co-processing of cohesive powder via Mechanical dry coating for direct tablet compression. 2017, Journal of Pharmaceutical Sciences, 106(1), 159–167. #

Zhou, Q.T., Loh, Z.H., Yu, J.Q., Sun, S., Gengenbach, T., Denman, J., Li, J., Chan, H.K. How much surface coating of hydrophobic azithromycin is sufficient to prevent moisture-induced decrease in aerosolisation of hygroscopic colistin powder? 2016, AAPS Journal, 18(5), 1213-1224. #

Schneider, E., Azad, M., Han, M., Zhou, Q., Wang, J., Huang, J., Cooper, M., Doi, Y., Baker, M., Bergen, P., Muller, M., Li, J., Velkov, T. An ‘unlikely’ pair: The antimicrobial synergy of polymyxin B in combination with the cystic fibrosis trans-membrane conductance regulator drugs KALYDECO and ORKAMBI. 2016, ACS Infectious Diseases, 2(7), 478-488. #

Leung, C.M.S., Tong, Z., Zhou, Q.T., Chan, J.G.Y., Tang, P., Sun, S., Yang, R., Chan, H.K. Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-based DPI Formulations. Part 1: Grid Structure. 2016, AAPS Journal, 18(5), 1159-1167. #

Qu, L., Morton, D.A.V., Zhou, Q.T.*, Particle Engineering by Practical and Scalable Intensive Mechanical Dry Coating Processes to Develop Highly-Efficient Dry Powder Inhaler Formulations. 2016, Inhalation, 10(3), 17-22. #

 Jong, T., Li, J., Morton, D.A.V.,* Zhou, Q.T.,* Larson, I.* Investigation of the changes in aerosolization behavior between the jet-milled and spray-dried colistin powders through surface energy characterization. 2016, Journal of Pharmaceutical Sciences, 105(3), 1156–1163. #

Wang, W. , Zhou, Q.T., Sun S., Denman J., Gengenbach, T., Barraud, N., Rice, S.A., Li, J., Yang, M., Chan, H.K. Effects of surface composition on the aerosolisation and dissolution of inhaled antibiotic combination powders consisting of colistin and rifampicin. 2016, AAPS Journal, 18(2) 372-384 ( co-first authors). #

Jin, L., Zhou, Q.T., Chan, H.K., Larson, I., Pennington, W.M., Boyd, J.B., Norton, S.R., Nicolazzo, A.J. Pulmonary delivery of the Kv1.3-blocking peptide HsTX1[R14A] for the treatment of autoimmune diseases, 2016, Journal of Pharmaceutical Sciences, 105(2), 650–656. (Virtual Issue – Most Original and Most Significant Scientific Findings) #

Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. Human Oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins, 2016, Journal of Antimicrobial Chemotherapy. 71 (2), 403-412. #

Zhou, Q.T., Chan, H.K. Emerging formulation design and drug delivery systems for inhaled therapy. 2015. Current Pharmaceutical Design, 21 (40), pp. 5749-5750. (Editorial) #

Zhou, Q.T., Morton, D.A.V. Advances in particle engineering and powder technology for pharmaceutical solid dosage forms. 2015. Current Pharmaceutical Design, 21 (27), pp. 3852. (Editorial) #

Qu, L., Morton, D.A.V.*, Zhou, Q.T.* Particle engineering via mechanical dry coating in the design of pharmaceutical solid dosage forms, 2015, Current Pharmaceutical Design. 21 (40), 5802-5814. #

Lin, Y., Wong, J., Chan, H. K.*, Zhou, Q. T.* Powder production and particle engineering for dry powder inhaler formulations, 2015, Current Pharmaceutical Design. 21(27), pp. 3902-3916. #

Leung, S.S.Y., Tang, P., Zhou, Q.T., Tong, Z., Leung, C., Decharaksa, J., Yang, R., Chan, H.K. De-agglomeration effect of the United States Pharmacopeia and Alberta throats on carrier-based powders in commercial inhalation products, 2015, AAPS Journal. 17 (6), pp. 1407-1416.

Qu, L., Zhou, Q.T., Denman, J., Stewart, P.J., Hapgood, K., Morton, D.A.V. Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders, 2015, European Journal of Pharmaceutical Sciences.78, pp. 264–272.

Zhou, Q. T., Sun, S.; Chan, J., Wang, P., Barraud, N., Rice, S., Wang, J., Li, J., Chan, H. K. A novel inhaled combination powder containing amorphous colistin and crystalline rifapentine with enhanced antimicrobial activities against planktonic cells and biofilm of Pseudomonas aeruginosa for respiratory infection. 2015. Molecular Pharmaceutics. 12 (8), pp. 2594–2603.

Velkov, T., Abdulrahim, N., Zhou, Q.T., Chan, H.K., Li, J., Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead. 2015. Advanced Drug Delivery Reviews 85, pp. 65-82. (Top 1% highly cited paper in Pharmacology & Toxicology by Web of Science as of March/April 2016)

Zhou, Q.T., Leung, S.S.Y., Tang, P., Thaigarajan, P., Loh Z.H., Chan, H.K., Inhalation formulation and drug delivery systems for respiratory infections. 2015. Advanced Drug Delivery Reviews 85, pp. 83-99. (Top 1% highly cited paper in Pharmacology & Toxicology by Web of Science as of March/April 2016)

Qu, L., Zhou, Q.T., Gengenbach, T., Denman, J., Hapgood, K., Gamlen, M., Stewart, P.J., Morton, D.A.V., Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. 2015. Drug Development and Industrial Pharmacy 41 (5), pp. 825-837.

Liang, W., Lau, P.N.N., Zhou, Q.T., Chow, M.Y.T., Kwok, P.C.L., Leung, G.P.H., Mason, A.J., Chan, H.K., Poon, L.L.M., Lam, J.K.W., Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza. 2015. Molecular Pharmaceutics 12 (3), pp. 910 -921.

Rajkhowa, R., Abdullah, K., Zhou Q.T., Kondor A., Morton D.A.V., Wang X. Relationship between processing, surface energy and bulk properties of ultrafine silk particles. 2015. Powder Technology 270, pp. 112-120.

Zhou, Q.T., Tang, P., Leung, S.S.Y., Chan, J.G.Y., Chan, H.K., Emerging inhalation aerosol devices and strategies: where are we headed? 2014. Advanced Drug Delivery Reviews, 75, pp. 3-17.

Chan, J.G.Y., Wong, J., Zhou, Q.T., Leung, S.S.Y., Chan, H.K., Advances in device and formulation technologies for pulmonary drug delivery. 2014. AAPS PharmSciTech, 15(4), pp. 882-897.

Zhou, Q.T., Gengenbach, T., Denman, J. A., Yu, H. H., Li, J., Chan, H.K. Synergistic antibiotic combination powders of colistin and rifampicin provide high aerosolization efficiency and moisture protection. 2014. AAPS Journal, 16(1), pp. 38-47.

Zhou, Q.T., Morton, D. A.V., Yu, H. H., Jacob, J., Wang, J., Li, J., Chan, H.K. Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. 2013. Journal of Pharmaceutical Sciences, 102 (10), pp. 3736-3747.

Zhou, Q.T., Tong, Z., Tang, P., Yang, R., Chan, H.K. Effect of device design on the aerosolization of a carrier-based dry powder inhaler- A case study on Aerolizer Foradile. 2013. AAPS Journal, 15 (2), pp. 511-522.

Zhou, Q.T.*, Li, Qu, Gengenbach, T., Larson, I., Stewart, P.J., Morton, D.A.V.* Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. 2013. AAPS PharmSciTech, 14, pp. 38-44.

Zhou, Q.T., Morton, D.A.V. Drug-Lactose Binding Aspects in Adhesive Mixtures: Controlling performance in Dry Powder Inhaler Formulations by Altering Lactose Carrier Surfaces. 2012. Advanced Drug Delivery Reviews, 64 (3), pp. 275-284. (Cover page)

Rajkhowa, R., Zhou, Q., Tsuzuki, T., Morton D.A.V., Wang, X., Ultrafine wool powders and their bulk properties. 2012. Powder Technology, 224 (3), pp. 183-188.

Zhou, Q.T., Gengenbach, T., Denman, J., Das, S., Li, Qu, Zhang H.L., Larson, I., Stewart, P.J., Morton, D.A.V. Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach, 2011. Journal of Pharmaceutical Sciences, 100 (8), pp. 3421-3430. 

Zhou, Q.T., Li, Qu, Larson, I., Stewart, P.J., Morton, D.A.V. Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: a model cohesive pharmaceutical powder. 2011. Powder Technology, 207 (1-3), pp. 414-427.

Zhou, Q.T., Li, Qu, Gengenbach, T., Denman, J., Larson, I., Stewart, P.J., Morton, D.A.V. Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. 2011. International Journal of Pharmaceutics, 413 (1-2), pp. 36-43.

Das, S.C., Zhou, Q., Morton, D.A.V., Larson, I., Stewart, P.J. Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. 2011. European Journal of Pharmaceutical Sciences, 43 (4), pp. 325-333.

Zhou, Q., Armstrong, B., Larson, I., Stewart, PJ., Morton D.A.V., Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. 2010. Journal of Pharmaceutical Sciences, 99 (2), pp. 969-981.

Zhou, Q.T., Armstrong, B., Larson, I., Stewart, P.J., Morton, D.A.V., Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders. 2010. European Journal of Pharmaceutical Sciences, 40 (5), pp. 412-421.

Zhou, Q.T., Li, Qu, Larson, I., Stewart, P.J., Morton, D.A.V. Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach. 2010. International Journal of Pharmaceutics, 394 (1-2), pp. 50-59.

Zhou, Q., Armstrong, B., Larson, I., Stewart, PJ., Morton D.A.V., Effect of host particle size on the modification of powder flow behaviours of lactose monohydrate following dry coating. 2010. Dairy Science and Technology, 90 (2-3), pp. 237-251. 

 Zhu, K., Tan, R.B.H., Kiong Ng, W., Shen, S., Zhou, Q., Heng, P.W.S. Analysis of the influence of relative humidity on the moisture sorption of particles and the aerosolization process in a dry powder inhaler. 2008. Journal of Aerosol Science, 39 (6), pp. 510-524.

Chan, L.W., Zhou, Q., Heng, P.W.S. Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers. 2007. Journal of Drug Delivery Science and Technology, 17 (3), pp. 217-222.

Karande, A. D., Zhou, Q., Chan, L. W., Heng, P. W. S. and Liew, C. V. Scanning Probe Microscopy for Surface Roughness Characterization of Lactose Carriers Used in Dry Powder Inhalation Therapy. 2007. Journal of Scanning Probe Microscopy, 2, pp. 5-9.

 

Full publication list: https://scholar.google.com/citations?user=KrwU6bQAAAAJ&hl=en

Mega Menu Visual Content