Yoon Yeo

Professor of Industrial and Physical Pharmacy and Biomedical Engineering, Associate Department Head, Industrial and Physical Pharmacy
Specialization: Tumor-targeted drug delivery, nanoparticle engineering, intracellular drug delivery, non-viral gene delivery, biomaterials for immunotherapy


Post-doctoral Associate, Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 2004-2006PhD, Pharmaceutics, Purdue University, West Lafayette, IN, 1999-2003Research Scientist, Sam Yang Co., Korea, 1995-1999MS, Microbial Chemistry, Seoul National University, Seoul, Korea, 1993-1995BS, Pharmacy, Seoul National University, Seoul, Korea, 1989-1993


Dr. Yeo’s research focuses on developing new drug delivery systems and biomaterials enabling safe, efficient, and clinically applicable delivery of drugs, genes, and/or cells in a target specific manner. Specifically, her lab is interested in nanoparticle surface engineering for drug delivery to solid tumors with a focus on cancer immunotherapy, intracellular delivery of peptide antibiotics, systemic delivery of gene therapeutics via non-viral carriers, and developing new drug formulations and biomaterials for therapy of infectious/inflammatory diseases.


See Yoon Yeo research web page.

Lab Members

Sheryhan F. G. Ahmed (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Yun-Chu Chen (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Dhawal Chobisa (Graduate Student with Dr. Yoon Yeo)
Hytham Gadalla (Graduate Student with Dr. Yoon Yeo)
Kunyu Jiang (Visiting Scholar with Dr. Yoon Yeo)
Nisar Ul Khaliq (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Hyungjun Kim (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Soonbum Kwon (Graduate Student with Dr. Yoon Yeo)
Yongzhe Li (Visiting Scholar with Dr. Yoon Yeo)
Fanfei Meng (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Jianping Wang (Graduate Student with Dr. Yoon Yeo)
Simseok Andrew Yuk (Graduate Student with Dr. Yoon Yeo)

Honors and Credentials

  • 2019 AAPS Fellow
  • 2014 Showalter Faculty Scholar
  • 2011 NSF CAREER Award
  • 2009 AAPS New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies
  • 2008 AACP New Investigators Program for Pharmacy Faculty

Representative Publications



Jun, Y., Xu, J., Kim, H., Park, J.E., Jeong, Y.S., Min, J.S., Yoon, N., Choi, J.Y., Yoo, J. Bae, S.K., Chung, S.J., Yeo, Y., and Lee, W. Carfilzomib delivery by quinic acid-conjugated nanoparticles: Discrepancy between tumoral drug accumulation and anticancer efficacy in a murine 4T1 orthotopic breast cancer model. J. Pharm. Sci. (2020) In press.

Taha, Maie; Cresswell, Gregory; Park, Joonyoung; Lee, Wooin; Ratliff, Timothy; Yeo, Yoon. Sustained delivery of carfilzomib by tannic acid-based nanocapsules helps develop antitumor immunity. Nano Letters. (2019) 19: 8333-8341.

Wang, Jianping*; Meng, Fanfei*; Kim, Bieong-Kil; Ke, Xue; Yeo, Yoon. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials. (2019) 217: 19296. (*: co-first authors)

Tamam, Hassan; Park, Jinho; Gadalla, Hytham; Masters, Andrea; Abdel-Aleem, Jelan; Abdelrahman, Sayed; Abdelrahman, Aly; Lyle, L. Tiffany; Yeo, Yoon. Development of liposomal gemcitabine with high drug loading efficiency. Molecular Pharmaceutics. (2019) 16: 2858-2871.

Park, Ji Eun; Park, Joonyoung; Jun, Yearin; Oh, Yunseok; Ryoo, Gongmi; Jeong, Yoo-Seong; Gadalla, Hytham H.; Min, Jee Sun; Jo, Jung Hwan; Song, Myung Geun; Kang, Keon Wook; Bae, Soo Kyung; Yeo, Yoon; and Lee, Wooin. Expanding Therapeutic Utility of Carfilzomib for Breast Cancer Therapy by Novel Albumin-coated Nanocrystal Formulation. Journal of Controlled Release. (2019) 302: 148-159.

Park, Jinho; Park, Joonyoung; Castanares, Mark; Collins, David; Yeo, Yoon. Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceutics. (2019) 16: 1864-1873.

Pang, Liang; Pei, Yihua; Uzunalli, Gozde; Hyun, Hyesun; Lyle, Tiffany; Yeo, Yoon. Surface modification of polymeric nanoparticles with M2pep peptide for drug delivery to tumor-associated macrophages. Pharmaceutical Research. (2019)36:65.

Meng, Fanfei; Wang, Jianping; Ping, Qineng; Yeo, Yoon. Camouflaging Nanoparticles for Ratiometric Delivery of Therapeutic Combinations. Nano Letters. (2019) 19(3): 1479–1487.

Xu, J.; Lee, S. S.-Y.; Seo, H.; Pang, L.; Jun, Y.; Zhang, R.-Y.; Zhang, Z.-Y.; Kim, P.; Lee, W.; Kron, S. J.; Yeo, Y. Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins. Small. (2018) 14: 1803601.

Hyun, H., Park, J., Willis, K.Y., Park, J.E., Lyle, L.T., Lee, W., Yeo, Y. Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors. Biomaterials. (2018) 180: 206-224.

Meng, F., Wang, J., Ping, Q., Yeo, Y. Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited. ACS Nano. (2018) 12: 6458–6468.

Yuk, S. A., Sanchez-Rodriguez, D.A., Tsifansky, M.D., Yeo, Y. Recent advances in nanomedicine for sepsis treatment. Therapeutic Delivery. (2018): 435–450

Park, J., Park, J.E., Hedrick, V.E., Wood, K.V., Bonham, C., Lee, W., Yeo, Y. A Comparative In Vivo Study of Albumin-Coated Paclitaxel Nanocrystals and Abraxane. Small. (2018) 14: 1703670.

Gad, S. F., Park, J., Park, J.E., Fetih, G.N., Tous, S.S., Lee, W., Yeo, Y. Enhancing docetaxel delivery to multidrug-resistant cancer cells with albumin-coated nanocrystals. Molecular Pharmaceutics. (2018) 15: 871−881.

Park, J., Pei, Y., Hyun, H., Castanares, M.A., Collins, D.S. and Yeo*, Y. Small molecule delivery to solid tumors with chitosan-coated PLGA particles: A lesson learned from comparative imaging. Journal of Controlled Release. (2017) 268: 407-415.

Kwak, G., Kim, D., Nam, G.H., Wang, S.Y., Kim, I.S., Kim, S.H., Kwon, I.C., Yeo*, Y. Programmed Cell Death Protein Ligand-1 (PD-L1) Silencing with Polyethylenimine-Dermatan Sulfate Complex for Dual Inhibition of Melanoma Growth. ACS Nano. (2017) 11: 10135–10146.

Liu, Y., Tamam, H. and Yeo*, Y. Mixed liposome approach for ratiometric and sequential delivery of paclitaxel and gemcitabine. AAPS PharmSciTech. (2018) 19: 693–699

Appelbe, O. K., Kim, B. K., Rymut, N., Wang, J., Kron*, S. J. and Yeo*, Y. Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex. Cancer Gene Therapy. doi:10.1038/s41417-017-0004-z.

Pei, Y., Mohamed, M.F., Seleem, M.N. and Yeo*, Y. Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages. Journal of Controlled Release. (2017) 267: 133-143.

Hyun, H., Hashimoto-Hill, S., Kim, M., Tsifansky, M.D., Kim, C.H. and Yeo*, Y. Succinylated chitosan derivative has local protective effects on intestinal inflammation. ACS Biomaterials Science & Engineering. (2017) 3(8): 1853–1860.

Kim, B.K., Kim, D., Yhee, J.Y., Kwon, I.C., Kim, S.H. and Yeo*, Y. Polyethylenimine-dermatan sulfate complex, a bioactive biomaterial with unique toxicity to CD146-positive cancer cells. ACS Biomaterials Science & Engineering. (2017) 3(6): 990–999. 

Han, N., Pang, L., Xu, J., Hyun, H., Park, J. and Yeo*, Y. Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics. (2017) 14(5): 1538–1547.

Park, J., Sun, B. and Yeo*, Y. Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Journal of Controlled Release. (2017) 263:90-101.

Meng, F., Han, N. and Yeo*, Y. Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Except Opinion on Drug Delivery. (2017) 14(3): 427-446.  

Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Han N, Pang L, Xu J, Hyun H, Park J, Yeo Y.Molecular pharmaceutics. 2017; 14(5):1538-1547. PubMed [journal], PMID: 28368124

Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Meng F, Han N, Yeo Y.

Expert opinion on drug delivery. 2017; 14(3):427-446. NIHMSID: NIHMS851869, PubMed [journal], PMID: 27476442, PMCID: PMC5385259

Polyethylenimine-Dermatan Sulfate Complex, a Bioactive Biomaterial with Unique Toxicity to CD146-Positive Cancer Cells

Kim B, Kim D, Kwak G, Yhee J, Kwon I, Kim S, Yeo Y., ACS Biomaterials Science & Engineering. 2017; My Bibliography [journal]

Succinylated Chitosan Derivative Has Local Protective Effects on Intestinal Inflammation, Hyun H, Hashimoto-Hill S, Kim M, Tsifansky MD, Kim CH.acs biomaterials science & Engineering. 2017; My Bibliography [journal]

Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Park J, Sun B, Yeo Y. Journal of controlled release: official journal of the Controlled Release Society. 2016;PubMed [journal] PMID: 28049022

Effects of Inhalable Microparticles of Seonpyejeongcheon-Tang in an Asthma Mouse Model: - Effects of Microparticles of SJT. Yang WK, Lee CH, Kim MH, Kim SH, Choi HY, Yeo Y, Park YC. Journal of pharmacopuncture. 2016; 19(4):303-311. PubMed [journal] PMID: 28097040 PMCID: PMC5234350


Yang, W.K., Lee, C.H., Kim, M.H., Kim, S.H., Choi, H.Y., Yeo, Y., and Park, Y.C. Effects of inhalable microparticles of Seonpyejeongcheon-Tang in an asthma mouse model. Journal of Pharmacopuncture. (2016) 19(4): 303-311.

Abouelmagd, S., Meng, F., Kim, B.K., Hyun, H., and Yeo*, Y. Tannic acid-mediated surface functionalization of polymeric nanoparticles. ACS Biomaterials Science & Engineering. (2016) 2(12): 2294–2303.

Cho, E.J., Doh, K.O., Park, J., Hyun, H., Wilson, E.M., Snyder, P.W., Tsifansky, M.D., Yeo*, Y. Zwitterionic chitosan for the systemic treatment of sepsis. Scientific Reports. (2016) 6, 29739; doi: 10.1038/srep29739

Park, J., Kadasala, N.R., Abouelmagd, S.A., Castanares, M.A., Collins, D.S., Wei, A., Yeo*, Y., Polymer-iron oxide composite nanoparticles for EPR-independent drug delivery. Biomaterials. (2016) 101: 285-295.

Sun, B., Taha, M.S., Ramsey, B., Torregrosa-Allen, S., Elzey, B.D., and Yeo*, Y. Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals. Journal of Controlled Release. (2016) 235: 91–98. Comment:  Featured in cover story of the issue.

Park, J., Park, J., Pei, Y., Xu, J., Yeo*, Y. Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines. Advanced Drug Delivery Reviews. (2016) 104: 93–109.

Pei, Y., Yeo*, Y. Drug delivery to macrophages: challenges and opportunities. Journal of Controlled Release. (2016) 240: 202-211.

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