Yoon Yeo

Photo
Professor of Industrial and Physical Pharmacy and Biomedical Engineering, Associate Department Head, Industrial and Physical Pharmacy
Phone:
765-496-9608
Fax:
765-494-6545
E-mail:
Specialization: Tumor-targeted drug delivery, nanoparticle engineering, intracellular drug delivery, non-viral gene delivery, biomaterials for immunotherapy

Education

Post-doctoral Associate, Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 2004-2006PhD, Pharmaceutics, Purdue University, West Lafayette, IN, 1999-2003Research Scientist, Sam Yang Co., Korea, 1995-1999MS, Microbial Chemistry, Seoul National University, Seoul, Korea, 1993-1995BS, Pharmacy, Seoul National University, Seoul, Korea, 1989-1993

Research

Dr. Yeo’s research focuses on developing new drug delivery systems and biomaterials enabling safe, efficient, and clinically applicable delivery of drugs, genes, and/or cells in a target specific manner. Specifically, her lab is interested in nanoparticle surface engineering for drug delivery to solid tumors with a focus on cancer immunotherapy, intracellular delivery of peptide antibiotics, systemic delivery of gene therapeutics via non-viral carriers, and developing new drug formulations and biomaterials for therapy of infectious/inflammatory diseases.

 

See Yoon Yeo research web page.

Lab Members

Sheryhan F. G. Ahmed (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Yun-Chu Chen (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Dhawal Chobisa (Graduate Student with Dr. Yoon Yeo)
Hytham Gadalla (Graduate Student with Dr. Yoon Yeo)
Nisar Ul Khaliq (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Hyungjun Kim (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Soonbum Kwon (Graduate Student with Dr. Yoon Yeo)
Fanfei Meng (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Jianping Wang (Graduate Student with Dr. Yoon Yeo)
Simseok Andrew Yuk (Post-Doctoral Research Assistant with Dr. Yoon Yeo)

Honors and Credentials

  • 2019 AAPS Fellow
  • 2014 Showalter Faculty Scholar
  • 2011 NSF CAREER Award
  • 2009 AAPS New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies
  • 2008 AACP New Investigators Program for Pharmacy Faculty

Representative Publications

https://www.ncbi.nlm.nih.gov/sites/myncbi/yoon.yeo.1/bibliography/41164990/public/?sort=date&direction=descending

http://scholar.google.com/citations?user=p85NBE4AAAAJ&hl=en

Taha, M., Creswell, C., Park, J., Lee, W., Ratliff, T., Yeo, Y. Sustained delivery of carfilzomib by tannic acid-based nanocapsules helps develop antitumor immunity. Nano Letters. (2019) 19: 8333-8341.

Wang, J., Meng, F., Kim, B. K., Ke, X., Yeo, Y. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials. (2019) 217: 19296.

Tamam, H., Park, J., Gadalla, H., Abdel-Aleem, J. A., Abdelrahman, S. I., Abdelrahman, A. A., Lyle, L.T., Yeo, Y. Development of liposomal gemcitabine with high drug loading efficiency. Molecular Pharmaceutics. (2019) 16: 2858-2871.

Park, J. E., Park, J., Jun, Y., Oh, Y., Ryoo, G., Jeong, Y.-S., Gadalla, H., Min, J. S., Jo, J. H., Song, M. G., Kang, K. W., Bae, S. K., Yeo, Y., and Lee, W. Expanding Therapeutic Utility of Carfilzomib for Breast Cancer Therapy by Novel Albumin-coated Nanocrystal Formulation. Journal of Controlled Release. (2019) 302: 148-159.

Park, J., Park, J., Castanares, M., Collins, D., Yeo, Y. Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceutics. (2019) 16: 1864-1873.

Pang, L., Pei, Y., Uzunalli, G., Hyun, H., Lyle, L.T., Yeo, Y. Surface modification of polymeric nanoparticles with M2pep peptide for drug delivery to tumor-associated macrophages. Pharmaceutical Research. (2019) 36:65.

Meng, F., Wang, J., Ping, Q., Yeo, Y. Camouflaging Nanoparticle Surface for Coordinated Delivery of Therapeutic Combinations. Nano Letters. (2019) 19: 1479-1487.

Jun, Y., Xu, J., Kim, H., Park, J.E., Jeong, Y.S., Min, J.S., Yoon, N., Choi, J.Y., Yoo, J. Bae, S.K., Chung, S.J., Yeo, Y., and Lee, W. Carfilzomib delivery by quinic acid-conjugated nanoparticles: Discrepancy between tumoral drug accumulation and anticancer efficacy in a murine 4T1 orthotopic breast cancer model. J. Pharm. Sci. (2020) In press.

Taha, Maie; Cresswell, Gregory; Park, Joonyoung; Lee, Wooin; Ratliff, Timothy; Yeo, Yoon. Sustained delivery of carfilzomib by tannic acid-based nanocapsules helps develop antitumor immunity. Nano Letters. (2019) 19: 8333-8341.

Wang, Jianping*; Meng, Fanfei*; Kim, Bieong-Kil; Ke, Xue; Yeo, Yoon. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials. (2019) 217: 19296. (*: co-first authors)

Tamam, Hassan; Park, Jinho; Gadalla, Hytham; Masters, Andrea; Abdel-Aleem, Jelan; Abdelrahman, Sayed; Abdelrahman, Aly; Lyle, L. Tiffany; Yeo, Yoon. Development of liposomal gemcitabine with high drug loading efficiency. Molecular Pharmaceutics. (2019) 16: 2858-2871.

Park, Ji Eun; Park, Joonyoung; Jun, Yearin; Oh, Yunseok; Ryoo, Gongmi; Jeong, Yoo-Seong; Gadalla, Hytham H.; Min, Jee Sun; Jo, Jung Hwan; Song, Myung Geun; Kang, Keon Wook; Bae, Soo Kyung; Yeo, Yoon; and Lee, Wooin. Expanding Therapeutic Utility of Carfilzomib for Breast Cancer Therapy by Novel Albumin-coated Nanocrystal Formulation. Journal of Controlled Release. (2019) 302: 148-159.

Park, Jinho; Park, Joonyoung; Castanares, Mark; Collins, David; Yeo, Yoon. Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceutics. (2019) 16: 1864-1873.

Pang, Liang; Pei, Yihua; Uzunalli, Gozde; Hyun, Hyesun; Lyle, Tiffany; Yeo, Yoon. Surface modification of polymeric nanoparticles with M2pep peptide for drug delivery to tumor-associated macrophages. Pharmaceutical Research. (2019)36:65.

Meng, Fanfei; Wang, Jianping; Ping, Qineng; Yeo, Yoon. Camouflaging Nanoparticles for Ratiometric Delivery of Therapeutic Combinations. Nano Letters. (2019) 19(3): 1479–1487.

Xu, J.; Lee, S. S.-Y.; Seo, H.; Pang, L.; Jun, Y.; Zhang, R.-Y.; Zhang, Z.-Y.; Kim, P.; Lee, W.; Kron, S. J.; Yeo, Y. Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins. Small. (2018) 14: 1803601.

Hyun, H., Park, J., Willis, K.Y., Park, J.E., Lyle, L.T., Lee, W., Yeo, Y. Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors. Biomaterials. (2018) 180: 206-224.

Meng, F., Wang, J., Ping, Q., Yeo, Y. Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited. ACS Nano. (2018) 12: 6458–6468.

Yuk, S. A., Sanchez-Rodriguez, D.A., Tsifansky, M.D., Yeo, Y. Recent advances in nanomedicine for sepsis treatment. Therapeutic Delivery. (2018): 435–450

Park, J., Park, J.E., Hedrick, V.E., Wood, K.V., Bonham, C., Lee, W., Yeo, Y. A Comparative In Vivo Study of Albumin-Coated Paclitaxel Nanocrystals and Abraxane. Small. (2018) 14: 1703670.

Gad, S. F., Park, J., Park, J.E., Fetih, G.N., Tous, S.S., Lee, W., Yeo, Y. Enhancing docetaxel delivery to multidrug-resistant cancer cells with albumin-coated nanocrystals. Molecular Pharmaceutics. (2018) 15: 871−881.

Park, J., Pei, Y., Hyun, H., Castanares, M.A., Collins, D.S. and Yeo*, Y. Small molecule delivery to solid tumors with chitosan-coated PLGA particles: A lesson learned from comparative imaging. Journal of Controlled Release. (2017) 268: 407-415.

Kwak, G., Kim, D., Nam, G.H., Wang, S.Y., Kim, I.S., Kim, S.H., Kwon, I.C., Yeo*, Y. Programmed Cell Death Protein Ligand-1 (PD-L1) Silencing with Polyethylenimine-Dermatan Sulfate Complex for Dual Inhibition of Melanoma Growth. ACS Nano. (2017) 11: 10135–10146.

Liu, Y., Tamam, H. and Yeo*, Y. Mixed liposome approach for ratiometric and sequential delivery of paclitaxel and gemcitabine. AAPS PharmSciTech. (2018) 19: 693–699

Appelbe, O. K., Kim, B. K., Rymut, N., Wang, J., Kron*, S. J. and Yeo*, Y. Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex. Cancer Gene Therapy. doi:10.1038/s41417-017-0004-z.

Pei, Y., Mohamed, M.F., Seleem, M.N. and Yeo*, Y. Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages. Journal of Controlled Release. (2017) 267: 133-143.

Hyun, H., Hashimoto-Hill, S., Kim, M., Tsifansky, M.D., Kim, C.H. and Yeo*, Y. Succinylated chitosan derivative has local protective effects on intestinal inflammation. ACS Biomaterials Science & Engineering. (2017) 3(8): 1853–1860.

Kim, B.K., Kim, D., Yhee, J.Y., Kwon, I.C., Kim, S.H. and Yeo*, Y. Polyethylenimine-dermatan sulfate complex, a bioactive biomaterial with unique toxicity to CD146-positive cancer cells. ACS Biomaterials Science & Engineering. (2017) 3(6): 990–999. 

Han, N., Pang, L., Xu, J., Hyun, H., Park, J. and Yeo*, Y. Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics. (2017) 14(5): 1538–1547.

Park, J., Sun, B. and Yeo*, Y. Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Journal of Controlled Release. (2017) 263:90-101.

Meng, F., Han, N. and Yeo*, Y. Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Except Opinion on Drug Delivery. (2017) 14(3): 427-446.  

Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Han N, Pang L, Xu J, Hyun H, Park J, Yeo Y.Molecular pharmaceutics. 2017; 14(5):1538-1547. PubMed [journal], PMID: 28368124

Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Meng F, Han N, Yeo Y.

Expert opinion on drug delivery. 2017; 14(3):427-446. NIHMSID: NIHMS851869, PubMed [journal], PMID: 27476442, PMCID: PMC5385259

Polyethylenimine-Dermatan Sulfate Complex, a Bioactive Biomaterial with Unique Toxicity to CD146-Positive Cancer Cells

Kim B, Kim D, Kwak G, Yhee J, Kwon I, Kim S, Yeo Y., ACS Biomaterials Science & Engineering. 2017; My Bibliography [journal]

Succinylated Chitosan Derivative Has Local Protective Effects on Intestinal Inflammation, Hyun H, Hashimoto-Hill S, Kim M, Tsifansky MD, Kim CH.acs biomaterials science & Engineering. 2017; My Bibliography [journal]

Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Park J, Sun B, Yeo Y. Journal of controlled release: official journal of the Controlled Release Society. 2016;PubMed [journal] PMID: 28049022

Effects of Inhalable Microparticles of Seonpyejeongcheon-Tang in an Asthma Mouse Model: - Effects of Microparticles of SJT. Yang WK, Lee CH, Kim MH, Kim SH, Choi HY, Yeo Y, Park YC. Journal of pharmacopuncture. 2016; 19(4):303-311. PubMed [journal] PMID: 28097040 PMCID: PMC5234350

 

Yang, W.K., Lee, C.H., Kim, M.H., Kim, S.H., Choi, H.Y., Yeo, Y., and Park, Y.C. Effects of inhalable microparticles of Seonpyejeongcheon-Tang in an asthma mouse model. Journal of Pharmacopuncture. (2016) 19(4): 303-311.

Abouelmagd, S., Meng, F., Kim, B.K., Hyun, H., and Yeo*, Y. Tannic acid-mediated surface functionalization of polymeric nanoparticles. ACS Biomaterials Science & Engineering. (2016) 2(12): 2294–2303.

Cho, E.J., Doh, K.O., Park, J., Hyun, H., Wilson, E.M., Snyder, P.W., Tsifansky, M.D., Yeo*, Y. Zwitterionic chitosan for the systemic treatment of sepsis. Scientific Reports. (2016) 6, 29739; doi: 10.1038/srep29739

Park, J., Kadasala, N.R., Abouelmagd, S.A., Castanares, M.A., Collins, D.S., Wei, A., Yeo*, Y., Polymer-iron oxide composite nanoparticles for EPR-independent drug delivery. Biomaterials. (2016) 101: 285-295.

Sun, B., Taha, M.S., Ramsey, B., Torregrosa-Allen, S., Elzey, B.D., and Yeo*, Y. Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals. Journal of Controlled Release. (2016) 235: 91–98. Comment:  Featured in cover story of the issue.

Park, J., Park, J., Pei, Y., Xu, J., Yeo*, Y. Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines. Advanced Drug Delivery Reviews. (2016) 104: 93–109.

Pei, Y., Yeo*, Y. Drug delivery to macrophages: challenges and opportunities. Journal of Controlled Release. (2016) 240: 202-211.

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