Yoon Yeo
Professor of Industrial and Physical Pharmacy and Biomedical Engineering
Education
Research
Dr. Yeo’s research focuses on developing new drug delivery systems and biomaterials enabling safe, efficient, and clinically applicable delivery of drugs, genes, and/or cells in a target specific manner. Specifically, her lab is interested in nanoparticle surface engineering for drug delivery to solid tumors with a focus on cancer immunotherapy, intracellular delivery of peptide antibiotics, systemic delivery of gene therapeutics via non-viral carriers, and developing new drug formulations and biomaterials for therapy of infectious/inflammatory diseases.
Lab Members
Dhawal Chobisa (Graduate Student with Dr. Yoon Yeo)
Marwa Elnaggar (Visiting Scholar with Dr. Yoon Yeo)
Yasmin Ahmed Eltellawy (Visiting Scholar with Dr. Yoon Yeo)
Hytham Gadalla (Graduate Student with Dr. Yoon Yeo)
Yanying (Crystal) He (Graduate Student with Dr. Yoon Yeo)
Woojun Kim (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Yongzhe (Zoe) Li (Graduate Student with Dr. Yoon Yeo)
Fanfei Meng (Post-Doctoral Research Associate with Dr. Yoon Yeo)
Sota Shishikura (Graduate Student with Dr. Yoon Yeo)
Hassan A. Tamam (Visiting Scholar with Dr. Yoon Yeo)
Jianping Wang (Graduate Student with Dr. Yoon Yeo)
Zhongyue (Claire) Yuan (PULSe Graduate Student with Dr. Yoon Yeo)
Honors and Credentials
- 2019 AAPS Fellow
- 2014 Showalter Faculty Scholar
- 2011 NSF CAREER Award
- 2009 AAPS New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies
- 2008 AACP New Investigators Program for Pharmacy Faculty
Representative Publications
http://scholar.google.com/citations?user=p85NBE4AAAAJ&hl=en
Book Chapter: Kwon, S., and Yeo, Y., Local immunotherapy of cancer and metastasis. In: Systemic Drug Delivery Strategies, Volume 2: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy. Mansoor Amiji and Lara Milane (Eds.), Elsevier. 2022. Chapter 18 pp
Simseok A. Yuk, Hyungjun Kim, Nader S. Abutaleb, Alexandra M. Dieterly, Maie S. Taha, Michael D. Tsifansky, L. Tiffany Lyle, Mohamed N. Seleem, Yoon Yeo. Nanocapsules modify membrane interaction of polymyxin B to enable safe systemic therapy of Gram-negative sepsis. Science Advances. (2021) 7: eabj1577.
Hyungjun Kim, Simseok A. Yuk, Alexandra M. Dieterly, Soonbum Kwon, Jinho Park, Fanfei Meng, Hytham H. Gadalla, Maria Jose Cadena, L. Tiffany Lyle, Yoon Yeo, Nanosac, a non-cationic and soft polyphenol nanocapsule, enables systemic delivery of siRNA to solid tumors. ACS Nano. (2021) 15(3): 4576–4593.
Seungbin Kwon, Kyung Bo Kim, Yoon Yeo, Wooin Lee, Pharmacokinetic aspects of the clinically used proteasome inhibitor drugs and efforts toward the novel nanoparticulate delivery systems. Journal of Pharmaceutical Investigation. (2021) 51: 483-502.
Yeo Jin Choi, Keunhyeong Bak, Yoon Yeo, Yong Won Choi, Sooyoung Shin. Incident type 2 diabetes risk of selective estrogen receptor modulators in female patients with breast cancer. Pharmaceutics. (2021) 14: 925.
Nisar Ul Khaliq; Dhawal Chobisa; Coralie A. Richard; Monica R. Swinney; Yoon Yeo. Engineering microenvironment of biodegradable polyester systems for drug stability and release control. Therapeutic Delivery. (2021) 12: 37-54.
Yun-Chu Chen; Sheryhan F. Ahmed; Dhawal Chobisa; Yongzhe Li; Yoon Yeo. Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities. Journal of Controlled Release. (2021) 330: 438-460.
Book Chapter: Meng, F., Kwon, S., Wang, J., and Yeo, Y. Immunoactive drug carriers in cancer therapy. In: Kinam Park (Ed.), Biomaterials for Cancer Therapeutics. Elsevier. 2020.
Marwa G. Elnaggar, Jiang Kunyu, Hassan E. Eldesouky, Yihua Pei, Jinho Park, Simseok Yuk, Fanfei Meng, Alexandra M Dieterly, Haroon T. Mohammad, Youssef A. Hegazy, Hesham M. Tawfeek, Aly A. Abdel-Rahman, Ahmed E. Aboutaleb, Mohamed M. Seleem, Yoon Yeo. Antibacterial Nanotruffles for Treatment of Intracellular Bacterial Infection. Biomaterials. (2020) 262: 120344.
Hyun Jung Park, Sung Won Lee, Yihua Pei, Yoon Yeo, and Seokmann Hong. Topical application of zwitterionic chitosan suppresses neutrophil-mediated acute skin inflammation. International Journal of Biological Macromolecules. (2020) 158: 1184-1193.
Hyungjun Kim, Heungsoo Lee, Yale Jeon, Woohyun Park, Yue Zhang, Bongjoong Kim, Hanmin Jang, Baoxing Xu, Yoon Yeo, Dong Rip Kim, Chi Hwan Lee. Bioresorbable, miniaturized porous silicon needles on flexible water-soluble backing for unobtrusive, sustained delivery of chemotherapy. ACS Nano. (2020) 14: 7227–7236.
Jun, Y., Xu, J., Kim, H., Park, J.E., Jeong, Y.S., Min, J.S., Yoon, N., Choi, J.Y., Yoo, J. Bae, S.K., Chung, S.J., Yeo, Y., and Lee, W. Carfilzomib delivery by quinic acid-conjugated nanoparticles: Discrepancy between tumoral drug accumulation and anticancer efficacy in a murine 4T1 orthotopic breast cancer model. J. Pharm. Sci. (2020) 109: 1615-1622.
Taha, M., Creswell, C., Park, J., Lee, W., Ratliff, T., Yeo, Y. Sustained delivery of carfilzomib by tannic acid-based nanocapsules helps develop antitumor immunity. Nano Letters. (2019) 19: 8333-8341.
Wang, J., Meng, F., Kim, B. K., Ke, X., Yeo, Y. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials. (2019) 217: 19296.
Tamam, H., Park, J., Gadalla, H., Abdel-Aleem, J. A., Abdelrahman, S. I., Abdelrahman, A. A., Lyle, L.T., Yeo, Y. Development of liposomal gemcitabine with high drug loading efficiency. Molecular Pharmaceutics. (2019) 16: 2858-2871.
Park, J. E., Park, J., Jun, Y., Oh, Y., Ryoo, G., Jeong, Y.-S., Gadalla, H., Min, J. S., Jo, J. H., Song, M. G., Kang, K. W., Bae, S. K., Yeo, Y., and Lee, W. Expanding Therapeutic Utility of Carfilzomib for Breast Cancer Therapy by Novel Albumin-coated Nanocrystal Formulation. Journal of Controlled Release. (2019) 302: 148-159.
Park, J., Park, J., Castanares, M., Collins, D., Yeo, Y. Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceutics. (2019) 16: 1864-1873.
Pang, L., Pei, Y., Uzunalli, G., Hyun, H., Lyle, L.T., Yeo, Y. Surface modification of polymeric nanoparticles with M2pep peptide for drug delivery to tumor-associated macrophages. Pharmaceutical Research. (2019) 36:65.
Meng, F., Wang, J., Ping, Q., Yeo, Y. Camouflaging Nanoparticle Surface for Coordinated Delivery of Therapeutic Combinations. Nano Letters. (2019) 19: 1479-1487.
Jun, Y., Xu, J., Kim, H., Park, J.E., Jeong, Y.S., Min, J.S., Yoon, N., Choi, J.Y., Yoo, J. Bae, S.K., Chung, S.J., Yeo, Y., and Lee, W. Carfilzomib delivery by quinic acid-conjugated nanoparticles: Discrepancy between tumoral drug accumulation and anticancer efficacy in a murine 4T1 orthotopic breast cancer model. J. Pharm. Sci. (2020) In press.
Taha, Maie; Cresswell, Gregory; Park, Joonyoung; Lee, Wooin; Ratliff, Timothy; Yeo, Yoon. Sustained delivery of carfilzomib by tannic acid-based nanocapsules helps develop antitumor immunity. Nano Letters. (2019) 19: 8333-8341.
Wang, Jianping*; Meng, Fanfei*; Kim, Bieong-Kil; Ke, Xue; Yeo, Yoon. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials. (2019) 217: 19296. (*: co-first authors)
Tamam, Hassan; Park, Jinho; Gadalla, Hytham; Masters, Andrea; Abdel-Aleem, Jelan; Abdelrahman, Sayed; Abdelrahman, Aly; Lyle, L. Tiffany; Yeo, Yoon. Development of liposomal gemcitabine with high drug loading efficiency. Molecular Pharmaceutics. (2019) 16: 2858-2871.
Park, Ji Eun; Park, Joonyoung; Jun, Yearin; Oh, Yunseok; Ryoo, Gongmi; Jeong, Yoo-Seong; Gadalla, Hytham H.; Min, Jee Sun; Jo, Jung Hwan; Song, Myung Geun; Kang, Keon Wook; Bae, Soo Kyung; Yeo, Yoon; and Lee, Wooin. Expanding Therapeutic Utility of Carfilzomib for Breast Cancer Therapy by Novel Albumin-coated Nanocrystal Formulation. Journal of Controlled Release. (2019) 302: 148-159.
Park, Jinho; Park, Joonyoung; Castanares, Mark; Collins, David; Yeo, Yoon. Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceutics. (2019) 16: 1864-1873.
Pang, Liang; Pei, Yihua; Uzunalli, Gozde; Hyun, Hyesun; Lyle, Tiffany; Yeo, Yoon. Surface modification of polymeric nanoparticles with M2pep peptide for drug delivery to tumor-associated macrophages. Pharmaceutical Research. (2019)36:65.
Meng, Fanfei; Wang, Jianping; Ping, Qineng; Yeo, Yoon. Camouflaging Nanoparticles for Ratiometric Delivery of Therapeutic Combinations. Nano Letters. (2019) 19(3): 1479–1487.
Xu, J.; Lee, S. S.-Y.; Seo, H.; Pang, L.; Jun, Y.; Zhang, R.-Y.; Zhang, Z.-Y.; Kim, P.; Lee, W.; Kron, S. J.; Yeo, Y. Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins. Small. (2018) 14: 1803601.
Hyun, H., Park, J., Willis, K.Y., Park, J.E., Lyle, L.T., Lee, W., Yeo, Y. Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors. Biomaterials. (2018) 180: 206-224.
Meng, F., Wang, J., Ping, Q., Yeo, Y. Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited. ACS Nano. (2018) 12: 6458–6468.
Yuk, S. A., Sanchez-Rodriguez, D.A., Tsifansky, M.D., Yeo, Y. Recent advances in nanomedicine for sepsis treatment. Therapeutic Delivery. (2018): 435–450
Park, J., Park, J.E., Hedrick, V.E., Wood, K.V., Bonham, C., Lee, W., Yeo, Y. A Comparative In Vivo Study of Albumin-Coated Paclitaxel Nanocrystals and Abraxane. Small. (2018) 14: 1703670.
Gad, S. F., Park, J., Park, J.E., Fetih, G.N., Tous, S.S., Lee, W., Yeo, Y. Enhancing docetaxel delivery to multidrug-resistant cancer cells with albumin-coated nanocrystals. Molecular Pharmaceutics. (2018) 15: 871−881.
Park, J., Pei, Y., Hyun, H., Castanares, M.A., Collins, D.S. and Yeo*, Y. Small molecule delivery to solid tumors with chitosan-coated PLGA particles: A lesson learned from comparative imaging. Journal of Controlled Release. (2017) 268: 407-415.
Kwak, G., Kim, D., Nam, G.H., Wang, S.Y., Kim, I.S., Kim, S.H., Kwon, I.C., Yeo*, Y. Programmed Cell Death Protein Ligand-1 (PD-L1) Silencing with Polyethylenimine-Dermatan Sulfate Complex for Dual Inhibition of Melanoma Growth. ACS Nano. (2017) 11: 10135–10146.
Liu, Y., Tamam, H. and Yeo*, Y. Mixed liposome approach for ratiometric and sequential delivery of paclitaxel and gemcitabine. AAPS PharmSciTech. (2018) 19: 693–699
Appelbe, O. K., Kim, B. K., Rymut, N., Wang, J., Kron*, S. J. and Yeo*, Y. Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex. Cancer Gene Therapy. doi:10.1038/s41417-017-0004-z.
Pei, Y., Mohamed, M.F., Seleem, M.N. and Yeo*, Y. Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages. Journal of Controlled Release. (2017) 267: 133-143.
Hyun, H., Hashimoto-Hill, S., Kim, M., Tsifansky, M.D., Kim, C.H. and Yeo*, Y. Succinylated chitosan derivative has local protective effects on intestinal inflammation. ACS Biomaterials Science & Engineering. (2017) 3(8): 1853–1860.
Kim, B.K., Kim, D., Yhee, J.Y., Kwon, I.C., Kim, S.H. and Yeo*, Y. Polyethylenimine-dermatan sulfate complex, a bioactive biomaterial with unique toxicity to CD146-positive cancer cells. ACS Biomaterials Science & Engineering. (2017) 3(6): 990–999.
Han, N., Pang, L., Xu, J., Hyun, H., Park, J. and Yeo*, Y. Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics. (2017) 14(5): 1538–1547.
Park, J., Sun, B. and Yeo*, Y. Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Journal of Controlled Release. (2017) 263:90-101.
Meng, F., Han, N. and Yeo*, Y. Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Except Opinion on Drug Delivery. (2017) 14(3): 427-446.
Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Han N, Pang L, Xu J, Hyun H, Park J, Yeo Y.Molecular pharmaceutics. 2017; 14(5):1538-1547. PubMed [journal], PMID: 28368124
Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Meng F, Han N, Yeo Y.
Expert opinion on drug delivery. 2017; 14(3):427-446. NIHMSID: NIHMS851869, PubMed [journal], PMID: 27476442, PMCID: PMC5385259
Polyethylenimine-Dermatan Sulfate Complex, a Bioactive Biomaterial with Unique Toxicity to CD146-Positive Cancer Cells
Kim B, Kim D, Kwak G, Yhee J, Kwon I, Kim S, Yeo Y., ACS Biomaterials Science & Engineering. 2017; My Bibliography [journal]
Succinylated Chitosan Derivative Has Local Protective Effects on Intestinal Inflammation, Hyun H, Hashimoto-Hill S, Kim M, Tsifansky MD, Kim CH.acs biomaterials science & Engineering. 2017; My Bibliography [journal]
Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Park J, Sun B, Yeo Y. Journal of controlled release: official journal of the Controlled Release Society. 2016;PubMed [journal] PMID: 28049022
Effects of Inhalable Microparticles of Seonpyejeongcheon-Tang in an Asthma Mouse Model: - Effects of Microparticles of SJT. Yang WK, Lee CH, Kim MH, Kim SH, Choi HY, Yeo Y, Park YC. Journal of pharmacopuncture. 2016; 19(4):303-311. PubMed [journal] PMID: 28097040 PMCID: PMC5234350
Yang, W.K., Lee, C.H., Kim, M.H., Kim, S.H., Choi, H.Y., Yeo, Y., and Park, Y.C. Effects of inhalable microparticles of Seonpyejeongcheon-Tang in an asthma mouse model. Journal of Pharmacopuncture. (2016) 19(4): 303-311.
Abouelmagd, S., Meng, F., Kim, B.K., Hyun, H., and Yeo*, Y. Tannic acid-mediated surface functionalization of polymeric nanoparticles. ACS Biomaterials Science & Engineering. (2016) 2(12): 2294–2303.
Cho, E.J., Doh, K.O., Park, J., Hyun, H., Wilson, E.M., Snyder, P.W., Tsifansky, M.D., Yeo*, Y. Zwitterionic chitosan for the systemic treatment of sepsis. Scientific Reports. (2016) 6, 29739; doi: 10.1038/srep29739
Park, J., Kadasala, N.R., Abouelmagd, S.A., Castanares, M.A., Collins, D.S., Wei, A., Yeo*, Y., Polymer-iron oxide composite nanoparticles for EPR-independent drug delivery. Biomaterials. (2016) 101: 285-295.
Sun, B., Taha, M.S., Ramsey, B., Torregrosa-Allen, S., Elzey, B.D., and Yeo*, Y. Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals. Journal of Controlled Release. (2016) 235: 91–98. Comment: Featured in cover story of the issue.
Park, J., Park, J., Pei, Y., Xu, J., Yeo*, Y. Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines. Advanced Drug Delivery Reviews. (2016) 104: 93–109.
Pei, Y., Yeo*, Y. Drug delivery to macrophages: challenges and opportunities. Journal of Controlled Release. (2016) 240: 202-211.