Yoon Yeo

Dr. Yeo’s research focuses on developing new drug delivery systems and biomaterials enabling safe, efficient, and clinically applicable delivery of drugs, genes, and/or cells in a target specific manner. Specifically, her lab is interested in nanoparticle surface engineering for drug delivery to solid tumors with a focus on cancer immunotherapy, intracellular delivery of peptide antibiotics, systemic delivery of gene therapeutics via non-viral carriers, and developing new drug formulations and biomaterials for therapy of infectious/inflammatory diseases.

See Yoon Yeo research web page.

• 2022 Controlled Release Society (CRS) Fellow
• 2021 Samyang CRS Award in Honor of Sung Wan Kim
• 2019 American Association of Pharmaceutical Scientists (AAPS) Fellow
• 2015 Bravo Award, Purdue University
• 2015 Chaney Family Early Scholar Award, College of Pharmacy, Purdue University
• 2014 The 2nd T. G. Park Award
• 2014 Showalter Faculty Scholar
• 2011 NSF CAREER Award
• 2009 AAPS New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies
• 2008 AACP New Investigators Program for Pharmacy Faculty

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ORCiD

Yun-Chu Chen, Sota Shishikura, Dana E. Moseson, Austin J. Ignatovich, Joshua Lomeo, Aiden Zhu, Sarena D. Horava, Coralie A. Richard, Kinam Park, Yoon Yeo. Control of Drug Release Kinetics from Hot-Melt Extruded Drug-loaded Polycaprolactone Matrices. Journal of Controlled Release. (2023) 359: 373-383.

Yingnan Shen, Simseok A. Yuk, Soonbum Kwon, Hassan Tamam, Yoon Yeo, and Bumsoo Han. A timescale-guided microfluidic synthesis of TA-FeIII network nanocapsules of hydrophobic drugs. Journal of Controlled Release. (2023) 357: 484-497.

Yihua Pei, Jianping Wang, Nisar Ul Khaliq, Fanfei Meng, Kaoutar A. Oucherif, Jie Xue, Coralie A. Richard, Monica R. Swinney, Sarena D. Horava, Amy L. Cox, Kinam Park, Yoon Yeo. Development of poly(lactic-co-glycolide) microparticles for sustained delivery of meloxicam. Journal of Controlled Release. (2023) 353: 823-831. 

Woojun Kim*, Nhu Ky Ly*, Yanying He*, Yongzhe Li*, Zhongyue Yuan*, Yoon Yeo. Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery. Advanced Drug Delivery Reviews. (2023) 192: 114635. (*: co-first authors)

Hytham H. Gadalla, Seongsoo Lee, Hyungjun Kim, Abigail T. Armstrong, Dina Fathalla, Fawzia Habib, Hyunyoung Jeong, Wooin Lee, Yoon Yeo. Size optimization of carfilzomib nanocrystals for systemic delivery to solid tumors. Journal of Controlled Release. (2022) 352: 637–651.

Lee Organski, Xingxing Wang, Andrew Meyers, Yun-Chu Chen, Kinam Park, Sarena D. Horava, Coralie A. Richard, Yoon Yeo, Alexey Shashurin. Inner Surface Modification of Polyethylene Tubing Induced by Dielectric Barrier Discharge Plasma. Journal of Vacuum Science & Technology A. 40, 063005 (2022); https://doi.org/10.1116/5.0119895

Anastasiia Vasiukhina, Sheryhan F. Gad, Elyssia N. Wellington, Danielle M. Wilmes, Yoon Yeo, Luis Solorio. PLA-PCL Microsphere Formulation to Deter Abuse of Prescription Opioids by Smoking. International Journal of Pharmaceutics. (2022) 626: 122151.

Fanfei Meng, Jianping Wang, Yanying He, Gregory M. Cresswell, Nadia A. Lanman, L. Tiffany Lyle, Timothy L. Ratliff, Yoon Yeo. A single local delivery of paclitaxel and nucleic acids via an immunoactive polymer eliminates tumors and induces antitumor immunity. PNAS. (2022) 119: e2122595119.

Fanfei Meng, Jianping Wang, Yoon Yeo. Nucleic acid and oligonucleotide delivery for activating innate immunity in cancer immunotherapy. Journal of Controlled Release. (2022) 345: 586-600.

Sooyoung Shin, Soonbum Kwon, Yoon Yeo. Meta-analysis of drug delivery approaches for treating intracellular infections. Pharmaceutical Research. (2022) 39: 1085-1114.

Yun-Chu Chen, Dana E. Moseson, Coralie A. Richard, Monica R. Swinney, Sarena D. Horava, Kaoutar Abbou Oucherif, Amy L. Cox, Eric D. Hawkins, Yongzhe Li, Daniel F DeNeve, Joshua Lomeo, Aiden Zhu, Eric J. Munson, Lynne S. Taylor, Kinam Park, Yoon Yeo. Development of hot-melt extruded drug/polymer matrices for sustained delivery of meloxicam. Journal of Controlled Release. (2022) 342: 189-200.

Simseok A. Yuk, Hyungjun Kim, Nader S. Abutaleb, Alexandra M. Dieterly, Maie S. Taha, Michael D. Tsifansky, L. Tiffany Lyle, Mohamed N. Seleem, Yoon Yeo.  Nanocapsules modify membrane interaction of polymyxin B to enable safe systemic therapy of Gram-negative sepsis. Science Advances. (2021) 7: eabj1577.

Hyungjun Kim, Simseok A. Yuk, Alexandra M. Dieterly, Soonbum Kwon, Jinho Park, Fanfei Meng, Hytham H. Gadalla, Maria Jose Cadena, L. Tiffany Lyle, Yoon Yeo, Nanosac, a non-cationic and soft polyphenol nanocapsule, enables systemic delivery of siRNA to solid tumors. ACS Nano. (2021) 15(3): 4576–4593.

Seungbin Kwon, Kyung Bo Kim, Yoon Yeo, Wooin Lee, Pharmacokinetic aspects of the clinically used proteasome inhibitor drugs and efforts toward the novel nanoparticulate delivery systems. Journal of Pharmaceutical Investigation. (2021) 51: 483-502.

Yeo Jin Choi, Keunhyeong Bak, Yoon Yeo, Yong Won Choi, Sooyoung Shin. Incident type 2 diabetes risk of selective estrogen receptor modulators in female patients with breast cancer. Pharmaceutics. (2021) 14: 925.

Nisar Ul Khaliq; Dhawal Chobisa; Coralie A. Richard; Monica R. Swinney; Yoon Yeo. Engineering microenvironment of biodegradable polyester systems for drug stability and release control. Therapeutic Delivery. (2021) 12: 37-54.

Yun-Chu Chen; Sheryhan F. Ahmed; Dhawal Chobisa; Yongzhe Li; Yoon Yeo. Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities. Journal of Controlled Release. (2021) 330: 438-460.

Book Chapter:  Meng, F., Kwon, S., Wang, J., and Yeo, Y. Immunoactive drug carriers in cancer therapy. In: Kinam Park (Ed.), Biomaterials for Cancer Therapeutics. Elsevier. 2020.

Marwa G. Elnaggar, Jiang Kunyu, Hassan E. Eldesouky, Yihua Pei, Jinho Park, Simseok Yuk, Fanfei Meng, Alexandra M Dieterly, Haroon T. Mohammad, Youssef A. Hegazy, Hesham M. Tawfeek, Aly A. Abdel-Rahman, Ahmed E. Aboutaleb, Mohamed M. Seleem, Yoon Yeo. Antibacterial Nanotruffles for Treatment of Intracellular Bacterial Infection. Biomaterials. (2020) 262: 120344.

Hyun Jung Park, Sung Won Lee, Yihua Pei, Yoon Yeo, and Seokmann Hong. Topical application of zwitterionic chitosan suppresses neutrophil-mediated acute skin inflammation. International Journal of Biological Macromolecules. (2020) 158: 1184-1193.

Hyungjun Kim, Heungsoo Lee, Yale Jeon, Woohyun Park, Yue Zhang, Bongjoong Kim, Hanmin Jang, Baoxing Xu, Yoon Yeo, Dong Rip Kim, Chi Hwan Lee. Bioresorbable, miniaturized porous silicon needles on flexible water-soluble backing for unobtrusive, sustained delivery of chemotherapy. ACS Nano. (2020) 14: 7227–7236.

Jun, Y., Xu, J., Kim, H., Park, J.E., Jeong, Y.S., Min, J.S., Yoon, N., Choi, J.Y., Yoo, J. Bae, S.K., Chung, S.J., Yeo, Y., and Lee, W. Carfilzomib delivery by quinic acid-conjugated nanoparticles: Discrepancy between tumoral drug accumulation and anticancer efficacy in a murine 4T1 orthotopic breast cancer model. J. Pharm. Sci. (2020) 109: 1615-1622.

Taha, M., Creswell, C., Park, J., Lee, W., Ratliff, T., Yeo, Y. Sustained delivery of carfilzomib by tannic acid-based nanocapsules helps develop antitumor immunity. Nano Letters. (2019) 19: 8333-8341.

Wang, J., Meng, F., Kim, B. K., Ke, X., Yeo, Y. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials. (2019) 217: 19296.

Tamam, H., Park, J., Gadalla, H., Abdel-Aleem, J. A., Abdelrahman, S. I., Abdelrahman, A. A., Lyle, L.T., Yeo, Y. Development of liposomal gemcitabine with high drug loading efficiency. Molecular Pharmaceutics. (2019) 16: 2858-2871.

Park, J. E., Park, J., Jun, Y., Oh, Y., Ryoo, G., Jeong, Y.-S., Gadalla, H., Min, J. S., Jo, J. H., Song, M. G., Kang, K. W., Bae, S. K., Yeo, Y., and Lee, W. Expanding Therapeutic Utility of Carfilzomib for Breast Cancer Therapy by Novel Albumin-coated Nanocrystal Formulation. Journal of Controlled Release. (2019) 302: 148-159.

Park, J., Park, J., Castanares, M., Collins, D., Yeo, Y. Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceutics. (2019) 16: 1864-1873.

Pang, L., Pei, Y., Uzunalli, G., Hyun, H., Lyle, L.T., Yeo, Y. Surface modification of polymeric nanoparticles with M2pep peptide for drug delivery to tumor-associated macrophages. Pharmaceutical Research. (2019) 36:65.

Meng, F., Wang, J., Ping, Q., Yeo, Y. Camouflaging Nanoparticle Surface for Coordinated Delivery of Therapeutic Combinations. Nano Letters. (2019) 19: 1479-1487.

Jun, Y., Xu, J., Kim, H., Park, J.E., Jeong, Y.S., Min, J.S., Yoon, N., Choi, J.Y., Yoo, J. Bae, S.K., Chung, S.J., Yeo, Y., and Lee, W. Carfilzomib delivery by quinic acid-conjugated nanoparticles: Discrepancy between tumoral drug accumulation and anticancer efficacy in a murine 4T1 orthotopic breast cancer model. J. Pharm. Sci. (2020) In press.

Taha, Maie; Cresswell, Gregory; Park, Joonyoung; Lee, Wooin; Ratliff, Timothy; Yeo, Yoon. Sustained delivery of carfilzomib by tannic acid-based nanocapsules helps develop antitumor immunity. Nano Letters. (2019) 19: 8333-8341.

Wang, Jianping*; Meng, Fanfei*; Kim, Bieong-Kil; Ke, Xue; Yeo, Yoon. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials. (2019) 217: 19296. (*: co-first authors)

Tamam, Hassan; Park, Jinho; Gadalla, Hytham; Masters, Andrea; Abdel-Aleem, Jelan; Abdelrahman, Sayed; Abdelrahman, Aly; Lyle, L. Tiffany; Yeo, Yoon. Development of liposomal gemcitabine with high drug loading efficiency. Molecular Pharmaceutics. (2019) 16: 2858-2871.

Park, Ji Eun; Park, Joonyoung; Jun, Yearin; Oh, Yunseok; Ryoo, Gongmi; Jeong, Yoo-Seong; Gadalla, Hytham H.; Min, Jee Sun; Jo, Jung Hwan; Song, Myung Geun; Kang, Keon Wook; Bae, Soo Kyung; Yeo, Yoon; and Lee, Wooin. Expanding Therapeutic Utility of Carfilzomib for Breast Cancer Therapy by Novel Albumin-coated Nanocrystal Formulation. Journal of Controlled Release. (2019) 302: 148-159.

Park, Jinho; Park, Joonyoung; Castanares, Mark; Collins, David; Yeo, Yoon. Magnetophoretic delivery of a tumor priming agent for chemotherapy of metastatic murine breast cancer. Molecular Pharmaceutics. (2019) 16: 1864-1873.

Pang, Liang; Pei, Yihua; Uzunalli, Gozde; Hyun, Hyesun; Lyle, Tiffany; Yeo, Yoon. Surface modification of polymeric nanoparticles with M2pep peptide for drug delivery to tumor-associated macrophages. Pharmaceutical Research. (2019)36:65.

Meng, Fanfei; Wang, Jianping; Ping, Qineng; Yeo, Yoon. Camouflaging Nanoparticles for Ratiometric Delivery of Therapeutic Combinations. Nano Letters. (2019) 19(3): 1479–1487.

Xu, J.; Lee, S. S.-Y.; Seo, H.; Pang, L.; Jun, Y.; Zhang, R.-Y.; Zhang, Z.-Y.; Kim, P.; Lee, W.; Kron, S. J.; Yeo, Y. Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins. Small. (2018) 14: 1803601.

Hyun, H., Park, J., Willis, K.Y., Park, J.E., Lyle, L.T., Lee, W., Yeo, Y. Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors. Biomaterials. (2018) 180: 206-224.

Meng, F., Wang, J., Ping, Q., Yeo, Y. Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited. ACS Nano. (2018) 12: 6458–6468.

Yuk, S. A., Sanchez-Rodriguez, D.A., Tsifansky, M.D., Yeo, Y. Recent advances in nanomedicine for sepsis treatment. Therapeutic Delivery. (2018): 435–450

Park, J., Park, J.E., Hedrick, V.E., Wood, K.V., Bonham, C., Lee, W., Yeo, Y. A Comparative In Vivo Study of Albumin-Coated Paclitaxel Nanocrystals and Abraxane. Small. (2018) 14: 1703670.

Gad, S. F., Park, J., Park, J.E., Fetih, G.N., Tous, S.S., Lee, W., Yeo, Y. Enhancing docetaxel delivery to multidrug-resistant cancer cells with albumin-coated nanocrystals. Molecular Pharmaceutics. (2018) 15: 871−881.

Park, J., Pei, Y., Hyun, H., Castanares, M.A., Collins, D.S. and Yeo*, Y. Small molecule delivery to solid tumors with chitosan-coated PLGA particles: A lesson learned from comparative imaging. Journal of Controlled Release. (2017) 268: 407-415.

Kwak, G., Kim, D., Nam, G.H., Wang, S.Y., Kim, I.S., Kim, S.H., Kwon, I.C., Yeo*, Y. Programmed Cell Death Protein Ligand-1 (PD-L1) Silencing with Polyethylenimine-Dermatan Sulfate Complex for Dual Inhibition of Melanoma Growth. ACS Nano. (2017) 11: 10135–10146.

Liu, Y., Tamam, H. and Yeo*, Y. Mixed liposome approach for ratiometric and sequential delivery of paclitaxel and gemcitabine. AAPS PharmSciTech. (2018) 19: 693–699

Appelbe, O. K., Kim, B. K., Rymut, N., Wang, J., Kron*, S. J. and Yeo*, Y. Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex. Cancer Gene Therapy. doi:10.1038/s41417-017-0004-z.

Pei, Y., Mohamed, M.F., Seleem, M.N. and Yeo*, Y. Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages. Journal of Controlled Release. (2017) 267: 133-143.

Hyun, H., Hashimoto-Hill, S., Kim, M., Tsifansky, M.D., Kim, C.H. and Yeo*, Y. Succinylated chitosan derivative has local protective effects on intestinal inflammation. ACS Biomaterials Science & Engineering. (2017) 3(8): 1853–1860.

Kim, B.K., Kim, D., Yhee, J.Y., Kwon, I.C., Kim, S.H. and Yeo*, Y. Polyethylenimine-dermatan sulfate complex, a bioactive biomaterial with unique toxicity to CD146-positive cancer cells. ACS Biomaterials Science & Engineering. (2017) 3(6): 990–999. 

Han, N., Pang, L., Xu, J., Hyun, H., Park, J. and Yeo*, Y. Development of surface-variable polymeric nanoparticles for drug delivery to tumors. Molecular Pharmaceutics. (2017) 14(5): 1538–1547.

Park, J., Sun, B. and Yeo*, Y. Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Journal of Controlled Release. (2017) 263:90-101.

Meng, F., Han, N. and Yeo*, Y. Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Except Opinion on Drug Delivery. (2017) 14(3): 427-446.  

Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Han N, Pang L, Xu J, Hyun H, Park J, Yeo Y.Molecular pharmaceutics. 2017; 14(5):1538-1547. PubMed [journal], PMID: 28368124

Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Meng F, Han N, Yeo Y.

Expert opinion on drug delivery. 2017; 14(3):427-446. NIHMSID: NIHMS851869, PubMed [journal], PMID: 27476442, PMCID: PMC5385259

Polyethylenimine-Dermatan Sulfate Complex, a Bioactive Biomaterial with Unique Toxicity to CD146-Positive Cancer Cells

Kim B, Kim D, Kwak G, Yhee J, Kwon I, Kim S, Yeo Y., ACS Biomaterials Science & Engineering. 2017; My Bibliography [journal]

Succinylated Chitosan Derivative Has Local Protective Effects on Intestinal Inflammation, Hyun H, Hashimoto-Hill S, Kim M, Tsifansky MD, Kim CH.acs biomaterials science & Engineering. 2017; My Bibliography [journal]

Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Park J, Sun B, Yeo Y. Journal of controlled release: official journal of the Controlled Release Society. 2016;PubMed [journal] PMID: 28049022

Effects of Inhalable Microparticles of Seonpyejeongcheon-Tang in an Asthma Mouse Model: - Effects of Microparticles of SJT. Yang WK, Lee CH, Kim MH, Kim SH, Choi HY, Yeo Y, Park YC. Journal of pharmacopuncture. 2016; 19(4):303-311. PubMed [journal] PMID: 28097040 PMCID: PMC5234350

Yang, W.K., Lee, C.H., Kim, M.H., Kim, S.H., Choi, H.Y., Yeo, Y., and Park, Y.C. Effects of inhalable microparticles of Seonpyejeongcheon-Tang in an asthma mouse model. Journal of Pharmacopuncture. (2016) 19(4): 303-311.

Abouelmagd, S., Meng, F., Kim, B.K., Hyun, H., and Yeo*, Y. Tannic acid-mediated surface functionalization of polymeric nanoparticles. ACS Biomaterials Science & Engineering. (2016) 2(12): 2294–2303.

Cho, E.J., Doh, K.O., Park, J., Hyun, H., Wilson, E.M., Snyder, P.W., Tsifansky, M.D., Yeo*, Y. Zwitterionic chitosan for the systemic treatment of sepsis. Scientific Reports. (2016) 6, 29739; doi: 10.1038/srep29739

Park, J., Kadasala, N.R., Abouelmagd, S.A., Castanares, M.A., Collins, D.S., Wei, A., Yeo*, Y., Polymer-iron oxide composite nanoparticles for EPR-independent drug delivery. Biomaterials. (2016) 101: 285-295.

Sun, B., Taha, M.S., Ramsey, B., Torregrosa-Allen, S., Elzey, B.D., and Yeo*, Y. Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals. Journal of Controlled Release. (2016) 235: 91–98. Comment:  Featured in cover story of the issue.

Park, J., Park, J., Pei, Y., Xu, J., Yeo*, Y. Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines. Advanced Drug Delivery Reviews. (2016) 104: 93–109.

Pei, Y., Yeo*, Y. Drug delivery to macrophages: challenges and opportunities. Journal of Controlled Release. (2016) 240: 202-211.