Lynne S. Taylor

Retter Professor of Pharmacy
Phone:
765-496-6614
Fax:
765-494-6545
Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

Education

Bachelor of Pharmacy with Honors, University of Bath, UK, 1990
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principal Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003

Research

Our overall goal is to enhance drug delivery by optimizing and understanding the physicochemical properties of drugs and excipients.  Of particular interest are amorphous solid dispersions which are used to improve the oral delivery of poorly water-soluble drugs. We are also interested in the stability of  pharmaceutical salts and the impact of excipients on product performance. For these types of solids, it is extremely important to understand drug-excipient interactions as well as the imapct of water on stability. We achieve an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques. Some of the analytical techniques that we use are infrared, Raman, ultraviolet and fluorescence spectroscopy, X-ray powder diffraction and differential scanning calorimetry.

Current Research Projects

 
1. Stabilization of amorphous solid dispersions through rational polymer selection
2. Second harmonic generation for the characterization of nanoscale crystallization. (collaboration with Professor G. Simpson, Chemistry, Purdue University)
3. Techniques to assess amorphous-amorphous miscibility
4. Novel polymers to stabilize amorphous solids (collaboration with Professor K. Edgar, Virginia Tech)
5. Stabilization of supersaturated solutions
6. Effect of polymers on crystal growth
7. Probing hygroscopicity and reactivity in crystalline and amorphous salts
8. Improving the solubility of phytochemicals
9. Disproportionation of pharmaceutical salts
10. Deliquescence in blends - chemical stability and powder properties (collaboration with Professor L. Mauer, Food Science, Purdue University)

Lab Members:

Vivekanand Bhardwaj (Visiting Scholar)
Clara E. Correa Soto (Graduate Student)
Tahnee Jade Dening (Visiting Scholar)
Van Tu Duong (Visiting Scholar)
Ahmed Elkhabaz (Graduate Student)
Siddhi S. Hate (Graduate Student)
Na Li (Post-Doctoral Research Associate)
Dana Moseson (Graduate Student)
Laura Mosquera-Giraldo (Graduate Student)
Naila A. Mugheirbi (Post-Doctoral Research Associate)
Andrew S. Parker (ChE Graduate Student)
Mitulkumar Ashokbhai (Mitul) Patel (Graduate Student)
Chailu Que (Graduate Student)
Sugandha Saboo (Graduate Student)
Dishan D. Shah (Graduate Student)
Masaru Sugita (Visiting Scholar)
Niraj Satish Trasi (Research Scientist)
Venecia Rochelle Wilson (Graduate Student)
Ruochen Yang (Graduate Student)

Teaching

IPPH 580

Honors and Credentials

Representative Publications

All publications

Li, N., Mosquera-Giraldo, L. I., Borca, C. H., Ormes, J. D., Lowinger, M. Higgins, J. D., Slipchenko, L.V., and Taylor, L. S. (2016)A Comparison of the Crystallization Inhibition Properties of Bile SaltsCrystal Growth and Design. 16(12):7286-7300. 

Tian, B., Tang, X., and Taylor, L. S. (2016). Investigating the Correlation between Miscibility and Physical Stability of Amorphous Solid Dispersions Using Fluorescence-based Techniques. Molecular Pharmaceutics. 13(11):3988-4000. 

Mosquera-Giraldo, L. I., Borca, C. H., Meng, X., Edgar, K. J., Slipchenko, L.V, and Taylor, L. S. (2016). Mechanistic Design of Chemically Diverse Polymers with Applications in Oral Drug DeliveryBiomacromolecules. 17(11):3659-3671. 

Nie, H., Su, Y., Zhang, M., Song, Y., Leone, A., Taylor, L.S., Marsac, P. J., Li, T., and Byrn, S. R. (2016). Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular Pharmaceutics. 13(11):3964-3975. 

Lu, M. and Taylor, L. S. (2016). Vemurafenib: A Tetramorphic System Displaying Concomitant Crystallization from the Supercooled Liquid. Crystal Growth and Design. 16(10):6033-6042. 

Nie, H., Xu, W., Ren, J., Taylor, L. S., Marsac, P. J., John, C. T., and Byrn, S. R. (2016). Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State FormulationsMolecular Pharmaceutics. 13(10):3541-3552. 

Dong, Y., Mosquera-Giraldo, L. I, Troutman, J., Skogstad, B., Taylor, L. S. and Edgar, K. J. (2016). Amphiphilic Hydroxyalkyl Cellulose Derivatives for Amorphous Solid Dispersion Prepared by Olefin Cross-Metathesis. Polymer Chemistry. 7:4953-4963.

Sun, D. D., Wen, H. and Taylor, L. S. (2016). Non-sink dissolution conditions for predicting product quality and in vivo performance of supersaturating drug delivery systemsJournal of Pharmaceutical Sciences. 105(9):2477-2488. 

Sato, T. and Taylor, L. S. (2015). Chiral Discrimination by a Cellulose Polymer: Differential Crystallization Inhibition of Enantiomers in Amorphous Dispersions. CrystEngComm. 17:5046-5053.

Schmitt, P. D., Trasi, N. S., Taylor, L. S. and Simpson, G. S. Finding the Needle in the Haystack – Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. (2015) Molecular Pharmaceutics. 12(7):2378-2383. 

Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2016). Exploiting the phenomenon of liquid-liquid phase separation for enhanced and sustained membrane transport of a poorly water soluble drug. Molecular Pharmaceutics. 13(6):2059-2069. 

Schram, C. J., Smyth, R. J., Taylor, L. S. and Beaudoin, S. P. (2016). Understanding Crystal Growth Kinetics in the Absence and Presence of a Polymer Using a Rotating Disk Apparatus. Crystal Growth and Design. 16(5):2640-2645. 

Li, N., Ormes, J. D. and Taylor, L. S. (2016). Leaching of Lopinavir Amorphous Solid Dispersions in Acidic MediaPharmaceutical Research. 33(7):1723-1735. 

Taylor, L. S. and Zhang, G. G. Z. (2016) Physical Chemistry of Supersaturated Solutions and Implications for Oral AbsorptionAdvanced Drug Delivery Reviews. 101:122-142. 

Alhalaweh, A., Bergström, C. A. S. and Taylor, L. S. (2016). Compromised in vitro dissolution and membrane transport of multidrug amorphous formulationsJournal of Controlled Release.229:172-182

Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Characterization of Highly Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions. Pharmaceutical Research. 33(5):1276-1288. 

Li., N. and Taylor, L. S. (2016). Nanoscale Infrared, Thermal, and Mechanical Characterization of Telaprevir-Polymer Miscibility in Amorphous Solid Dispersions Prepared by Solvent Evaporation. Molecular Pharmaceutics. 13(3):1123-1136. 

Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2016). Polymer Inhibition of Crystal Growth by Surface Poisoning. Crystal Growth and Design. 16(4):2094-2103. 

Xie, T., and Taylor, L. S. (2016). Improved Release of Celexocib from High Drug Loading Amorphous Solid Dispersions Formulated with Polyacrylic Acid and Cellulose Derivatives. Molecular Pharmaceutics.13(3):873-884. 

Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2016). Supersaturation Potential of Salt, Co-Crystal and Amorphous Forms of a Model Weak BaseCrystal Growth and Design. 16(2):737-748.

Dong, Y., Mosquera-Giraldo, L. I., Taylor, L. S. and Edgar, K. J. (2016). Design of Functionalized Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-MetathesisBiomacromolecules. 17(2):454-465.

Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type. Molecular Pharmaceutics. 13(1):223-231. 

Xie, T., and Taylor, L. S. (2016). Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations. Pharmaceutical Research. 33(3):739-750.

Nie, H., Liu, Z., Marks, B. C., Taylor, L. S., Byrn, S. R. and Marsac, P. J. (2016). Analytical Approaches to Investigate Salt Disproportionation in Tablet Matrices by Raman Spectroscopy and Raman MappingJournal of Pharmaceutical and Biomedical Analysis. 118:328-337

Allan, M., Taylor, L. S. and Mauer, L. J. (2016). Common-Ion Effects on the Deliquescence Lowering of Crystalline Ingredient Blends. Food Chemistry. 195:2-10.

Li, N., Taylor, L. S. and Mauer, L. J. (2016). Heat Transport Model for the Deliquescence Kinetics of Crystalline Ingredients and Mixtures. Journal of Food Engineering. 169:298-308. 

Nie, H., Mo, H., Zhang, M., Song, Y., Fang, K., Taylor, L. S., Li, T. and. Byrn, S. R. (2015). Investigating the interaction pattern and structural elements of a drug-polymer complex at the molecular level. Molecular Pharmaceutics. 12(7)2459-2468. 

Trasi, N. S. and Taylor, L. S. (2015). Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs – Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products. Journal of Pharmaceutical Sciences. 104(8):2583-2593.

Indulkar, A., Box, K. J., Taylor, R., Ruiz, R., and Taylor, L. S. (2015). pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs. Molecular Pharmaceutics. 12(7):2365-2377. 

Purohit, H. S. and Taylor, L. S. Phase Separation Kinetics in Amorphous Solid Dispersions Upon Exposure to Water. (2015) Molecular Pharmaceutics. 12(5):1623-1635. 

Chen, J., Mosquera-Giraldo L., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015). Bile Salts as Crystallization Inhibitors of Supersaturated Solutions of Poorly Water-Soluble Compounds. Crystal Growth and Design. 15(6):2593-2597.

Raina, S. A., Van Eerdenbrug, B., Alonzo, D. E., Mo, H., Zhang, G. G. Z., Gao, Y. and Taylor, L. S. (2015). Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs Assessed using Synchrotron Radiation. Journal of Pharmaceutical Sciences. 104(6):1981-1992.

Içten, E., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2015). Dropwise Additive Manufacturing of Pharmaceutical Products for Melt-Based Dosage Forms. Journal of Pharmaceutical Sciences. 104(5):1641-1649.

Toth, S., Schmitt, P. D., Snyder, G. R., Trasi, N. S., George, I. A.,  Taylor, L. S. and Simpson, G. J. (2015) Ab Initio Prediction of the Diversity of Second Harmonic Generation from Pharmaceutically Relevant Materials. Crystal Growth Design. 15(2):581-586. 

Chen, J., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015) Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles. Molecular Pharmaceutics. 12(2):533-541.

Trasi, N. S., Abbou-Oucherif, K., Litster, J. D. and Taylor, L. S. (2015)  Evaluating the Influence of Polymers on Nucleation and Growth in Supersaturated Solutions of Acetaminophen. CrystEngComm. 17:1242-1248.

Mosquera-Giraldo L., and Taylor, L. S. (2015) Glass-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir. (2015) Molecular Pharmaceutics. 12(2):496-501.

Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2015). Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches. Molecular Pharmaceutics. 12(2):484-495. 

Hsieh, Y-L., and Taylor, L. S. (2015). Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion. Pharmaceutical. Research. 32(2):549-561.

Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2015). Impact of Polymer Conformation on the Crystal Growth Inhibition of a Poorly Water Soluble Drug in Aqueous Solution. Langmuir. 31(1):171-179.

 Hsu, H-Y, Adigun, O. O., Taylor, L. S., Murad, S. and Harris, M. T. (2015). Impact of Surface Chemistry on Crystallization of Acetaminophen.  Chemical Engineering Science. 126:1-9.

Lipasek, R.A., Li, N., Taylor, L. S. and Mauer, L. J. (2015) Effect of temperature and initial moisture content on the chemical stability and color change of various forms of vitamin C. International Journal of Food Properties. 18(4):862-879.

Mega Menu Visual Content