Stephen R. Byrn, Ph.D. Charles B. Jordan Professor of Medicinal Chemistry Phone: 765-714-2808 Fax: (765) 494-6545 (765) 497-7290 E-mail: sbyrn@purdue.edu Full directory listing

Specialization: Develop the field of solid state chemistry of drugs so that all of the principles and factors governing solid state chemistry are understood. Knowledge will then be used to predict & analyze all behaviors of solids observed during drug development process

Education

Research: Develop the field of solid state chemistry of drugs so that all of the principles and factors governing solid state chemistry are understood. Knowledge will then be used to predict & analyze all behaviors of solids observed during drug development process

The overall goal of our research is to develop the field of Solid State Chemistry of Drugs so that all of the principles and factors governing solid state chemistry are understood. This knowledge will then be used to predict and analyze all behaviors of solids observed during the drug development process. Thus, the solid state chemistry of drugs is being studied to improve knowledge of the factors which affect this chemistry and to develop new methods of studying these reactions. At present, our group is focusing on stability and stability prediction/anticipation. We are also interested solid state desolvation reactions, solid state decarboxylation reactions, solid-solid reactions, and solid state rearrangements. These studies are important in that they will lead to better understanding of the mechanism of drug degradation and eventually to new approaches to stabilizing drugs. In addition, we are focusing on determining the relationship between thermal motion as measured by solid state NMR spectroscopy and X-ray crystallography, and solid state reactivity. This research has implications for the analysis of drugs, the stability of drugs, the control of drug production, and the development of methods of crystallization. By carrying out research on the solid state chemistry of drugs it is hoped that new approaches and ideas for drug analysis including solid state NMR spectroscopy will be developed. In addition, this research is aimed at providing new insight into drug stability and at developing methods for predicting drug stability. Furthermore, approaches to the production via crystallization of the desired drug form are an important component of these studies.

Honors and Credentials

Dr. Stephen R. Byrn received the 2009 David Grant Research Achievement Award in Physical Pharmacy on August 25, 2009.

Representative Publications

Joshi, V.; Morris, K.R.; Byrn, S.R.; Carvajal, M.T. Evaluation of the Use of Ea (Activation Energy) as a Quantitative Indicator of Physical Stability of Indomethacin Solvates: Methanolate and Tertiary Butyl Alcohol Solvate. Crystal Growth & Design 9(8), 3359-3366 (2009).

Hu, Y.; Wikstr���¶m, H.; Byrn, S. R.; Taylor, L.S. Estimation of the transition temperature for an enantiotropic polymorphic system from the transformation kinetics monitored using Raman spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 45(4), 546-551 (2007)

Liang, J.K.; Byrn, S.R. On-line Raman spectroscopy in pharmaceutical process development: application and future prospects. American Pharmaceutical Review 10(4), 45-51 (2007)

McBride, J. M.; Smith, D. T.; Byrn, S. R.; Borgens, R. B.; Shi, R. 4-Aminopyridine derivatives enhance impulse conduction in guinea-pig spinal cord following traumatic injury. Neuroscience, 148(1), 44-52 (2007)

Li, H.; Stowell, J.G.; He, X.; Morris, K.R.; Byrn, S.R., Investigations on solid-solid phase transformation of 5-methyl-2-[(4-methyl-2-nitrophenyl)amino]-3-thiophenecarbonitrile. Journal of Pharmaceutical Sciences 96(5), 1079-1089 (2007)

Henck, J.O.; and Byrn, S.R., Designing a Molecular Delivery System in a Preclinical Timeframe, Drug Discovery Today, 12, 189-199 (2007)

Crooks, P.A.; Kottayil, S.G.; Al-Ghananeem, A.M.; Byrn, S.R.; Butterfield, D. A. Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorganic & Medicinal Chemistry Letters, 16(16), 4291-4295 (2006)

Mao, C.; Chamarthy, S.P.; Byrn, S.R.; Pinal, R. A Calorimetric Method to Estimate Molecular Mobility of Amorphous Solids at Relatively Low Temperatures. Pharmaceutical Research, 23(10), 2269-2276 (2006)

Li, H. Stowell, J.G.; Borchardt, T. B.; Byrn, S.R. Synthesis, Conformational Polymorphism, and Construction of a G-T Diagram of 2-[(2-Nitrophenyl)amino]-3-thiophenecarbonitrile. Crystal Growth & Design, 6(11), 2469-2474 (2006)

Atassi, F. and Byrn, S R. General Trends in the Desolvation Behavior of Calcium Salts. Pharmaceutical Research, 23(10), 2405-2412, (2006)

Curriculum Vitae

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