Stephen R. Byrn, Ph.D. Charles B. Jordan Professor of Medicinal Chemistry Phone: (765) 714-2808 Fax: (765) 494-6545 (765) 497-7290 E-mail: sbyrn@purdue.edu Full directory listing

Education

Research

Solid state chemistry of drugs and solid state reactions including polymorphs, nanoparticles, liquid crystals, cocrystals, and noncrystalline materials. Analytical methods in the solid state including X-ray diffraction and solid state NMR. Formulation and manufacturing.

The solid state chemistry of drugs is being studied to: (1) improve knowledge of the factors that affect this chemistry; (2) develop new analytical methods; (3) develop platforms for formulation design especially as they relate to pediatric formulations; (4) understand the molecular basis of manufacturing, and (5) to be able to assess the risk of instability of APIs and formulations. Another goal of our research is to understand methods of making nanoparticles and to develop X-ray methods of analyzing them. Additionally, the chemistry of liquid crystals is being investigated. Of special interest is the use of PDF to analyze the structure of liquid crystals, nanoparticles, and amorphous materials. This solid state research has implications for the analysis of drugs, the stability of drugs, the control of drug manufacturing, and the development of methods of crystallization. By carrying out research on the solid state chemistry of drugs it is hoped that new approaches for drug analysis including solid state NMR spectroscopy will be developed. Finally, all of this information is used to develop new approaches to accelerating proof of concept.

Current Research Projects

1. Structure and phase diagrams of liquid crystals
2. Nanoparticle preparation and analysis
3. Analysis of liquid crystals and nanoparticles using X-ray diffraction and solid state NMR
4. Preparation, crystallization, and scale-up of cocrystals
5. Effect of milling on crystalline materials
6. Impurity mapping as a method to detect counterfeit medications
7. Pediatric formulation design including taste masking
8. Molecular basis of manufacturing
9. Algorithms for assessing the risk of instability
10. Accelerating drugs to proof of concept

Honors and Credentials

Dr. Stephen R. Byrn received the 2009 David Grant Research Achievement Award in Physical Pharmacy on August 25, 2009.

Representative Publications

Joshi, V.; Morris, K.R.; Byrn, S.R.; Carvajal, M.T. Evaluation of the Use of Ea (Activation Energy) as a Quantitative Indicator of Physical Stability of Indomethacin Solvates: Methanolate and Tertiary Butyl Alcohol Solvate. Crystal Growth & Design 9(8), 3359-3366 (2009).

Hu, Y.; Wikström, H.; Byrn, S. R.; Taylor, L.S. Estimation of the transition temperature for an enantiotropic polymorphic system from the transformation kinetics monitored using Raman spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 45(4), 546-551 (2007)

Liang, J.K.; Byrn, S.R. On-line Raman spectroscopy in pharmaceutical process development: application and future prospects. American Pharmaceutical Review 10(4), 45-51 (2007)

McBride, J. M.; Smith, D. T.; Byrn, S. R.; Borgens, R. B.; Shi, R. 4-Aminopyridine derivatives enhance impulse conduction in guinea-pig spinal cord following traumatic injury. Neuroscience, 148(1), 44-52 (2007)

Li, H.; Stowell, J.G.; He, X.; Morris, K.R.; Byrn, S.R., Investigations on solid-solid phase transformation of 5-methyl-2-[(4-methyl-2-nitrophenyl)amino]-3-thiophenecarbonitrile. Journal of Pharmaceutical Sciences 96(5), 1079-1089 (2007)

Henck, J.O.; and Byrn, S.R., Designing a Molecular Delivery System in a Preclinical Timeframe, Drug Discovery Today, 12, 189-199 (2007)

Crooks, P.A.; Kottayil, S.G.; Al-Ghananeem, A.M.; Byrn, S.R.; Butterfield, D. A. Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorganic & Medicinal Chemistry Letters, 16(16), 4291-4295 (2006)

Mao, C.; Chamarthy, S.P.; Byrn, S.R.; Pinal, R. A Calorimetric Method to Estimate Molecular Mobility of Amorphous Solids at Relatively Low Temperatures. Pharmaceutical Research, 23(10), 2269-2276 (2006)

Li, H. Stowell, J.G.; Borchardt, T. B.; Byrn, S.R. Synthesis, Conformational Polymorphism, and Construction of a G-T Diagram of 2-[(2-Nitrophenyl)amino]-3-thiophenecarbonitrile. Crystal Growth & Design, 6(11), 2469-2474 (2006)

Atassi, F. and Byrn, S R. General Trends in the Desolvation Behavior of Calcium Salts. Pharmaceutical Research, 23(10), 2405-2412, (2006)

Curriculum Vitae

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