Print-only header

Department of Industrial and Physical Pharmacy Personnel - Lynne S. Taylor

Lynne S. Taylor, PhD
Professor of Industrial and Physical Pharmacy
Phone: 765-496-6614
Fax: 765-494-6545
E-mail: lstaylor@purdue.edu
Lab webpage: http://taylor.openwetware.org/

Full directory listing
Picture of Lynne S. Taylor
Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

Education

Bachelor of Pharmacy with Honors, University of Bath, UK, 1990
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principle Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003

Research: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

Our overall goal is to enhance drug delivery by optimizing and understanding the physicochemical properties of drugs and excipients.  Of particular interest are amorphous solid dispersions which are used to improve the oral delivery of poorly water-soluble drugs, as well as pharmaceutical salts. For these types of solids, it is extremely important to understand drug-excipient interactions as well as the imapct of water on stability. We achieve an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques. Some of the analytical techniques that we use are infrared, Raman, ultraviolet and fluorescence spectroscopy, X-ray powder diffraction and differential scanning calorimetry.

 

Current Research Projects

 
1. Stabilization of amorphous solid dispersions through rational polymer selection
2. Second harmonic generation for the characterization of nanoscale crystallization. (collaboration with Professor G. Simpson, Chemistry, Purdue University)
3. Techniques to assess amorphous-amorphous miscibility
4. Novel polymers to stabilize amorphous solids(collaboration with Professor K. Edgar, Virginia Tech)
5. Stabilization of supersaturated solutions
6. Effect of polymers on crystal growth
7. Probing hygroscopicity and reactivity in crystalline and amorphous salts
8. Improving the solubility of phytochemicals
9. Disproportionation of pharmaceutical salts
10. Deliquescence in blends - chemical stability and powder properties (collaboration with Professor L. Mauer, Food Science, Purdue University)

Lab Members:

Amjad Alhalaweh (Visiting Scholar with Dr. Lynne Taylor)
Clara E. Correa Soto (Visiting Scholar)
Ahmed Elkhabaz (Graduate Student)
Alireza Ghaffari (Visiting Scholar with Dr. Lynne Taylor)
Anura Suresh Indulkar (Graduate Student)
Matthew James Jackson (Graduate Student)
Na Li (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Laura Mosquera-Giraldo (Graduate Student)
Hitesh Shridev Purohit (Graduate Student)
Chailu Que (Graduate Student)
Luis Filipe Ramalho de Almeida e Sousa (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Caitlin Schram (Graduate Student)
Niraj Satish Trasi (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Joaquin F. Urbina (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Venecia Rochelle Wilson (Graduate Student)
Tian Xie (Graduate Student)

Teaching

IPPH 580

Honors and Credentials

Representative Publications

All publications

Trasi, N., Baird, J. A. and Kestur, U. S. and Taylor, L. S. (2014). Factors Influencing Crystal Growth Rates from Undercooled Liquids of Pharmaceutical Compounds. Journal of Physical Chemistry B. 118(33):9974-9982.

Marks, J., Wegiel, L. A., Taylor, L. S. and Edgar, K. J. (2014). Pairwise Polymer Blends for Oral Drug Delivery. Journal of Pharmaceutical Sciences. 103(9):2871-2883. 

Trasi, N. and Taylor, L. S. (2014). Nucleation and Crystal Growth of Amorphous Nilutamide –Unusual Low Temperature Behavior. CrystEngComm. 16:7186-7195.

Hsieh, Y-L., Box, K. and Taylor, L. S. (2014). Assessing the Impact of Polymers on the pH-Induced Precipitation Behavior of Poorly Water Soluble Compounds using Synchrotron Wide Angle X-Ray Scattering. Journal of Pharmaceutical Sciences. 103(9):2724-2735.

Raina, S. A., Zhang, G. G. Z., Alonzo, D. E., Wu, J., Zhu, D., Catron, N. D., Gao, Y. and Taylor, L. S. (2014).Enhancements and Limits in Drug Membrane Transport Using Supersaturated Solutions of Poorly Water Soluble Drugs. Journal of Pharmaceutical Sciences. 103(9):2736-2748.

Liu, H., Ilevbare, G. A., Cherniawskia, B. P., Ritchie, E. T., Taylor, L. S. and Edgar, K. J. (2014). Synthesis and Structure-property Evaluation of Cellulose ω-carboxyesters for Amorphous Solid Dispersions. Carbohydrate Polymers. 100:116-125. 

Hirshfield, L., Giridhar, A., Taylor, L. S., Harris, M. T., Reklaitis, G. V. (2014). Dropwise Additive Manufacturing of Pharmaceutical Products for Solvent-Based Dosage Forms. Journal of Pharmaceutical Sciences. 103(2):496-506.

Mosquera-Giraldo L., Trasi, N. S., and Taylor, L. S. (2014) Impact of Surfactants on the Crystal Growth of Amorphous Celecoxib. International Journal of Pharmaceutics. 461(1-2):251-257.

 Hsieh, Y-L., Yu, W., Xiang, Y., Pan, W., Waterman, K. C., Shalaev, E. Y., Shamblin, S. L. and Taylor, L. S. (2014).Impact of Sertraline Salt Form on the Oxidative Stability in Powder Blends. International Journal of Pharmaceutics. 461(1-2):322-330.

Van Eerdenbrugh, B., Raina, S. A., Hsieh, Y-L., Augustijns, P. and Taylor, L. S. (2014). Classification of the Crystallization Behavior of Amorphous Active Pharmaceutical Ingredients in Aqueous Environments. Pharmaceutical Research. 31(4):969-982.

Wegiel, L.A., Mauer, L.J. , Edgar, K.J., and Taylor, L.S. (2014). Curcumin Amorphous Solid Dispersions: The Influence of Intra and Intermolecular Bonding on Physical Stability. Pharmaceutical Development and Technology. 19(8):976-986.

Wegiel, L.A., Mauer, L.J. , Edgar, K.J., and Taylor, L.S. (2014). Mid-Infrared Spectroscopy as a Polymer Selection Tool for Formulating Amorphous Solid Dispersions. Journal of Pharmacy and Pharmacology. 66(2):244-255.


All publications for Lynne S. Taylor (an Adobe Acrobat file)

Curriculum Vitae

Click here for a full CV for Lynne S. Taylor. (an Adobe Acrobat file)

This record was last updated on Aug 27, 2014 at 8:33 AM
E-mail Webmaster
Maintained by: College of Pharmacy
This page was last modified at 10:28 AM on March 21, 2011
Purdue University, Department of Industrial and Physical Pharmacy
575 Stadium Mall Drive, West Lafayette, IN 47907-2091,  (765) 494-1450, FAX: (765) 494-6545
© 2003-2014 Purdue University | An equal access/equal opportunity university | Copyright Complaints
If you have trouble accessing this page because of a disability, please contact us at webmaster@pharmacy.purdue.edu.