Department of Industrial and Physical Pharmacy Personnel - Lynne S. Taylor
Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions
EducationBachelor of Pharmacy, University of Bath, UK, 1990
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principle Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003
Research: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions
Our overall goal is to enhance drug delivery by optimizing and understanding the physicochemical properties of drugs and excipients. Of particular interest are amorphous solid dispersions which are used to improve the oral delivery of poorly water-soluble drugs, as well as pharmaceutical salts. For these types of solids, it is extremely important to understand drug-excipient interactions as well as the imapct of water on stability. We achieve an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques. Some of the analytical techniques that we use are infrared, Raman, ultraviolet and fluorescence spectroscopy, X-ray powder diffraction and differential scanning calorimetry.
Current Research Projects
Honors and Credentials
Ilevbare, G. A., Liu, H., Pereira, J., Edgar, K. J., Taylor, L.S. (2013). Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir. Molecular Pharmaceutics. 10(9):3392-3403.
Ilevbare, G. A. Liu, H, Edgar, K. J., Taylor, L.S. (2013). Impact of Polymers on the Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution. Molecular Pharmaceutics. 10(6):2381–2393.
Ilevbare, G. A. and Taylor, L. S. (2013). Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly-Water Soluble Drugs – Implications for Solubility Enhancing Formulations. Crystal Growth and Design. 13(4):1497-1509.
Li, B., Konecke, S., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013) Both Solubility and Chemical Stability of Curcumin are Enhanced by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 98: 1108-1116.
Li, B., Liu, H., Amin, M., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013).Enhancement of Naringenin Solution Concentration by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 20(4): 2137-2149.
MaltaÅï¿½, D. C., Kwok, K., Wang, P., Taylor, L. S. and Ben-Amotz, D. (2013) Rapid Classification of Pharmaceutical Ingredients with Raman Spectroscopy Using Compressive Detection Strategy with PLS-DA Multivariate Filters.Journal of Pharmaceutical and Biomedical Analysis.80:63-68.
Zhou, Q., Toth, S J., Simpson, G. J., Hsu H-Y., Taylor L. S., Harris, M. T., (2013) Crystallization and Dissolution Behavior of Naproxen/Polyethylene Glycol Solid Dispersions. Journal of Physical Chemistry. 117(5):1494-1500.
Ilevbare, G. A., Liu, H, Edgar, K. J., Taylor, L.S. (2013). Maintaining Supersaturation in Aqueous Drug Solutions - Impact of Different Polymers on Induction Times. Crystal Growth and Design. 13(2):740-751.
Toth SJ, Madden JT, Taylor LS, Marsac PJ, and Simpson, GJ. Selective Imaging of Active Pharmaceutical Ingredients in Powdered Blends with Common Excipients Utilizing Two-Photon Excited Ultraviolet-Fluorescence and Ultraviolet-Second Order Nonlinear Optical Imaging of Chiral Crystals. Analytical Chemistry 84(14) (2012): 5859-5875.
Kestur, U. S., Ivanisevic, I, Alonzo, D. E. and Taylor, L. S. (2013). Influence of Particle Size on the Crystallization Kinetics of Amorphous Felodipine Powders. Powder Technology.236:197–204.
Hsu, H-Y, Toth, S. J., Simpson, G. J., Taylor, L. S., Harris, M. T. (2013) Effect of Substrates on Naproxen\Polyvinylpyrrolidone Solid Dispersions Formed via the Drop Printing Technique. Journal of Pharmaceutical Sciences. 102(2):638-648.
Liu, H., Ilevbare, G. A., Cherniawskia, B. P., Ritchie, E. T., Taylor, L. S. and Edgar, K. J. (2013). Synthesis and Structure-property Evaluation of Cellulose ω-carboxyesters for Amorphous Solid Dispersions. Carbohydrate Polymers.
Abbou Oucherif, K. Raina, S., Taylor, L. S. and Litster, J. (2013) Quantitative Analysis of the Inhibitory Effect of HPMC on Felodipine Crystallization Kinetics Using Population Balance Modeling. CrystEngComm. 15:2197-2205.
Christensen, N. P. A., Van Eerdenbrugh, B., Kwok, K., Taylor, L. S., Bond, A. D. Rades, T., Rantanen, J., Cornett, C. (2013) Rapid Insight into Heating-induced Phase Transformations in the Solid-state of the Calcium Salt of Atorvastatin using Multivariate Data Analysis.Pharmaceutical Research. 30(3):826-835.All publications for Lynne S. Taylor (an Adobe Acrobat file)
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This record was last updated on Sep 25, 2013 at 10:41 AM