Lynne S. Taylor, Ph.D. Associate Professor of Industrial and Physical Pharmacy Phone: (765) 496-6614 Fax: (765) 494-6545 E-mail: lstaylor@purdue.edu Lab webpage: http://taylor.openwetware.org/ Full directory listing

Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

Education

Research: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

In general, our research interests are directed towards an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques with an emphasis on vibrational spectroscopy. Of particular interest are water-solid interactions and disordered systems, especially amorphous solid dispersions. Vibrational spectroscopy, in conjunction with other techniques such as X-ray diffraction and calorimetry, is used to provide information about the physical state of the substance e.g. crystalline or amorphous, the response of the material to changes in temperature and relative humidity and the nature of drug-drug, drug-excipient and drug-water interactions. Recently, we have been using Raman spectroscopy to monitor phase changes during pharmaceutical processing operations in real time.

Current Research Projects
1. Stabilization of amorphous solid dispersions through rational polymer selection
2. Moisture-induced immiscibility in solid dispersions
3. Techniques to assess amorphous-amorphous miscibility
4. Novel polymers to stabilize amorphous solids(collaboration with Professor K. Edgar, Virginia Tech)
5. Stabilization of supersaturated solutions
6. Effect of polymers on crystal growth
7. Probing hygroscopicity and reactivity in crystalline and amorphous salts
8. Chemical structure of water on salt surfaces
9. Effect of excipients on drug chemical stability - understanding the mechanism of action
10. Deliquescence in blends - chemical stability and powder properties (collaboration with Professor L. Mauer, Food Science, Purdue University)

Representative Publications

Wikström, H., Kakidas, C. and Taylor, L.S. (2009). Determination of hydrate transition temperature using transformation kinetics obtained using Raman spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 49:247-252.

Marsac, P.J., Li, T., and Taylor, L. S. (2009) Estimation of Drug-Polymer Miscibility and Solubility in Amorphous Solid Dispersions using Experimentally Determined Interaction Parameters. Pharmaceutical Research. 26(1):139-151.

Konno, H., Handa, T., Alonzo, D. E. and Taylor, L. S. (2008) Effect of Polymer Type on the Dissolution Profile of Amorphous Solid Dispersions Containing Felodipine. European Journal of Pharmaceutics and Biopharmaceutics. 70:493-499.

Hiatt, A.N. Ferruzzi, M., Taylor, L.S., and Mauer, L. J. (2008) ) Impact of deliquescence on the chemical stability of vitamins B1, B6, and C in powder blends. Journal of Agricultural and Food Chemistry. 56 (15): 6471-6479.

Towler C. S., Li, T. Wikström, H, Remmick, D., Sanchez-Felix M. V. and Taylor, L. S. (2008) An investigation into the influence of counter-ion on the properties of some amorphous organic salts. Molecular Pharmaceutics. 5 (6): 946-955.

Wikström, H.; Rantanen, J.; Gift, A. D. and Taylor, L. S. (2008) Towards an understanding of the factors influencing anhydrate-to-hydrate transformation kinetics in aqueous environments. Crystal Growth and Design. 8 (8): 2684-2693.

Towler, C.S., and Taylor, L.S. (2007) Spectroscopic Characterization of Inter-Molecular Interactions in Solution and Their Influence on Crystallization Outcome. Crystal Growth and Design 7(4):633-638.

Gift, A.D., and Taylor, L.S. (2007) Hyphenation of Raman Spectroscopy with Gravimetric Analysis to Interrogate Water-Solid Interactions in Pharmaceutical Systems. Journal of Pharmaceutical and Biomedical Analysis 43:14-23.

Guerrieri P., Salameh A.K., and Taylor, L.S. (2007) Effect of Small Levels of Impurities on the Moisture Sorption Behavior of Ranitidine HCl. Pharmaceutical Research 24(1):147-156.

Salameh, A.K., and Taylor, L.S. (2006) Deliquescence Induced Caking in Binary Powder Blends. Pharmaceutical Development and Technology 11:453-464.

Curriculum Vitae

Click here for a full CV for Lynne S. Taylor. (an Adobe Acrobat file)