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Department of Industrial and Physical Pharmacy Personnel - Lynne S. Taylor

Lynne S. Taylor, PhD
Professor of Industrial and Physical Pharmacy
Phone: 765-496-6614
Fax: 765-494-6545
E-mail: lstaylor@purdue.edu
Lab webpage: http://taylor.openwetware.org/

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Picture of Lynne S. Taylor
Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

Education

Bachelor of Pharmacy with Honors, University of Bath, UK, 1990
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principle Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003

Research: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

Our overall goal is to enhance drug delivery by optimizing and understanding the physicochemical properties of drugs and excipients.  Of particular interest are amorphous solid dispersions which are used to improve the oral delivery of poorly water-soluble drugs, as well as pharmaceutical salts. For these types of solids, it is extremely important to understand drug-excipient interactions as well as the imapct of water on stability. We achieve an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques. Some of the analytical techniques that we use are infrared, Raman, ultraviolet and fluorescence spectroscopy, X-ray powder diffraction and differential scanning calorimetry.

Current Research Projects


1. Stabilization of amorphous solid dispersions through rational polymer selection
2. Second harmonic generation for the characterization of nanoscale crystallization. (collaboration with Professor G. Simpson, Chemistry, Purdue University)
3. Techniques to assess amorphous-amorphous miscibility
4. Novel polymers to stabilize amorphous solids(collaboration with Professor K. Edgar, Virginia Tech)
5. Stabilization of supersaturated solutions
6. Effect of polymers on crystal growth
7. Probing hygroscopicity and reactivity in crystalline and amorphous salts
8. Improving the solubility of phytochemicals
9. Disproportionation of pharmaceutical salts
10. Deliquescence in blends - chemical stability and powder properties (collaboration with Professor L. Mauer, Food Science, Purdue University)

Lab Members:

Jie Chen (Research Scientist with Dr. Lynne Taylor)
Alireza Ghaffari (Visiting Scholar with Dr. Lynne Taylor)
Anura Suresh Indulkar (Graduate Student)
Matthew James Jackson (Graduate Student)
Laura Mosquera-Giraldo (Graduate Student)
Kaoutar Abbou (Coco) Oucherif (CHE Graduate Student (Litster))
Hitesh Shridev Purohit (Graduate Student)
Norbert Radacsi (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Shweta A. Raina (Graduate Student)
Luis Filipe Ramalho de Almeida e Sousa (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Niraj Satish Trasi (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Venecia Rochelle Wilson (Graduate Student)
Tian Xie (Graduate Student)

Teaching

IPPH 580

Honors and Credentials

  • 2012 Ebert Prize (Best paper in the Journal of Pharmaceutical Sciences)
  • Fellow of the American Association of Pharmaceutical Scientists
  • Fellow of the Royal Society of Chemistry
  • University Faculty Scholar 2009-2014
  • Entrepreneurial Leadership Academy Fellow 2008-2009
  • AAPS Outstanding Manuscript in Pharmaceutical Analysis and Quality 2008
  • AACP New Investigator Grant 2003
  • AAPS New Investigator Award 2003

Representative Publications

Ilevbare, G. A., Liu, H., Pereira, J., Edgar, K. J., Taylor, L.S. (2013). Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir. Molecular Pharmaceutics. 10(9):3392-3403.

Ilevbare, G. A. Liu, H, Edgar, K. J., Taylor, L.S. (2013). Impact of Polymers on the Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution. Molecular Pharmaceutics. 10(6):2381–2393.

Ilevbare, G. A. and Taylor, L. S. (2013). Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly-Water Soluble Drugs – Implications for Solubility Enhancing Formulations. Crystal Growth and Design. 13(4):1497-1509.

 Li, B., Konecke, S., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013) Both Solubility and Chemical Stability of Curcumin are Enhanced by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 98: 1108-1116.

 Li, B., Liu, H., Amin, M., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013).Enhancement of Naringenin Solution Concentration by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 20(4): 2137-2149.

MaltaÅ�, D. C., Kwok, K., Wang, P., Taylor, L. S. and Ben-Amotz, D. (2013) Rapid Classification of Pharmaceutical Ingredients with Raman Spectroscopy Using Compressive Detection Strategy with PLS-DA Multivariate Filters.Journal of Pharmaceutical and Biomedical Analysis.80:63-68.

Zhou, Q., Toth, S J., Simpson, G. J., Hsu H-Y., Taylor L. S., Harris, M. T., (2013) Crystallization and Dissolution Behavior of Naproxen/Polyethylene Glycol Solid Dispersions. Journal of Physical Chemistry. 117(5):1494-1500.

Ilevbare, G. A., Liu, H, Edgar, K. J., Taylor, L.S. (2013). Maintaining Supersaturation in Aqueous Drug Solutions - Impact of Different Polymers on Induction Times. Crystal Growth and Design. 13(2):740-751.

Toth SJ, Madden JT, Taylor LS, Marsac PJ, and Simpson, GJ. Selective Imaging of Active Pharmaceutical Ingredients in Powdered Blends with Common Excipients Utilizing Two-Photon Excited Ultraviolet-Fluorescence and Ultraviolet-Second Order Nonlinear Optical Imaging of Chiral Crystals. Analytical Chemistry 84(14) (2012): 5859-5875. 

Kestur, U. S., Ivanisevic, I, Alonzo, D. E. and Taylor, L. S. (2013). Influence of Particle Size on the Crystallization Kinetics of Amorphous Felodipine Powders. Powder Technology.236:197–204.

Hsu, H-Y, Toth, S. J., Simpson, G. J., Taylor, L. S., Harris, M. T. (2013) Effect of Substrates on Naproxen\Polyvinylpyrrolidone Solid Dispersions Formed via the Drop Printing Technique. Journal of Pharmaceutical Sciences. 102(2):638-648.

 Liu, H., Ilevbare, G. A., Cherniawskia, B. P., Ritchie, E. T., Taylor, L. S. and Edgar, K. J. (2013). Synthesis and Structure-property Evaluation of Cellulose ω-carboxyesters for Amorphous Solid Dispersions. Carbohydrate Polymers.

Abbou Oucherif, K. Raina, S., Taylor, L. S. and Litster, J. (2013) Quantitative Analysis of the Inhibitory Effect of HPMC on Felodipine Crystallization Kinetics Using Population Balance Modeling. CrystEngComm. 15:2197-2205.

Christensen, N. P. A., Van Eerdenbrugh, B., Kwok, K., Taylor, L. S., Bond, A. D. Rades, T., Rantanen, J., Cornett, C. (2013) Rapid Insight into Heating-induced Phase Transformations in the Solid-state of the Calcium Salt of Atorvastatin using Multivariate Data Analysis.Pharmaceutical Research. 30(3):826-835. 

All publications for Lynne S. Taylor (an Adobe Acrobat file)

Curriculum Vitae

Click here for a full CV for Lynne S. Taylor. (an Adobe Acrobat file)

This record was last updated on Feb 14, 2014 at 11:31 AM
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