Department of Industrial and Physical Pharmacy Personnel - Lynne S. Taylor

Lynne S. Taylor, PhD Professor of Industrial and Physical Pharmacy Phone: (765) 496-6614 Fax: (765) 494-6545 E-mail: lstaylor@purdue.edu Lab webpage: http://taylor.openwetware.org/ Full directory listing

Education

Research: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions

In general, our research interests are directed towards an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques with an emphasis on vibrational spectroscopy. Of particular interest are water-solid interactions and disordered systems, especially amorphous solid dispersions. Vibrational spectroscopy, in conjunction with other techniques such as X-ray diffraction and calorimetry, is used to provide information about the physical state of the substance e.g. crystalline or amorphous, the response of the material to changes in temperature and relative humidity and the nature of drug-drug, drug-excipient and drug-water interactions. Where possible, we use in situ monitoring techniques to improve the connectivity of the analysis technique to the process of interest.

Current Research Projects

1. Stabilization of amorphous solid dispersions through rational polymer selection
2. Second harmonic generation for the characterization of nanoscale crystallization. (collaboration with Professor G. Simpson, Chemistry, Purdue University)
3. Techniques to assess amorphous-amorphous miscibility
4. Novel polymers to stabilize amorphous solids(collaboration with Professor K. Edgar, Virginia Tech)
5. Stabilization of supersaturated solutions
6. Effect of polymers on crystal growth
7. Probing hygroscopicity and reactivity in crystalline and amorphous salts
8. Improving the solubility of phytochemicals
9. Disproportionation of pharmaceutical salts
10. Deliquescence in blends - chemical stability and powder properties (collaboration with Professor L. Mauer, Food Science, Purdue University)

Teaching

IPPH 580

Honors and Credentials

• 2012 Ebert Prize (Best paper in the Journal of Pharmaceutical Sciences)
• Fellow of the Royal Society of Chemistry
• University Faculty Scholar 2009-2014
• Entrepreneurial Leadership Academy Fellow 2008-2009
• AAPS Outstanding Manuscript in Pharmaceutical Analysis and Quality 2008
• AACP New Investigator Grant 2003
• AAPS New Investigator Award 2003

Representative Publications

Back KR, Davey RJ, Grecu T, Hunter CA and Taylor LS. Molecular Conformation and Crystallization: The Case of Ethenzamide. Crystal Growth & Design 12 (2012): 6110-6117.

Christensen NP, Rantanen J, Cornett C, and Taylor LS. Disproportionation of the calcium salt of atorvastatin in the presence of acidic excipients. Eur J Pharma Biopharm 82 (2012): 410-416.

Ilevbare GA, Liu HY, Edgar KJ, and Taylor LS. Effect of Binary Additive Combinations on Solution Crystal Growth of the Poorly Water-Soluble Drug, Ritonavir. Crystal Growth & Design 12 (2012): 6050-6060.

Kestur US, Wanapun D, Toth SJ, Wegiel LA, Simpson GJ, and Taylor LS. Nonlinear optical imaging for sensitive detection of crystals in bulk amorphous powders. J Pharm Sci 101 (2012): 4201-4213.

Li N, Taylor LS, Ferruzzi MG, and Mauer LJ. Kinetic Study of Catechin Stability: Effects of pH, Concentration, and Temperature. J Agric Food Chem 60 (2012): 12531-12539.

Trasi NS, and Taylor LS. Effect of polymers on nucleation and crystal growth of amorphous acetaminophen. CrystEngComm 14 (2012): 5188-5197.

Ilevbare G A, Liu H, Edgar KJ, Taylor LS. Inhibition of Solution Crystal Growth of Ritonavir by Cellulose Polymers – Factors Influencing Polymer Effectiveness. CrystEngComm 14 (2012): 6503-6514.

Toth SJ, Madden JT, Taylor LS, Marsac PJ, and Simpson, GJ. Selective Imaging of Active Pharmaceutical Ingredients in Powdered Blends with Common Excipients Utilizing Two-Photon Excited Ultraviolet-Fluorescence and Ultraviolet-Second Order Nonlinear Optical Imaging of Chiral Crystals. Analytical Chemistry 84(14) (2012): 5859-5875. 

Trasi NS and Taylor LS. Effect of Polymers on Nucleation and Crystal Growth of Amorphous Acetaminophen. CrystEngComm 14(16) (2012): 5188-5197. 

Hsieh Y-L, Ilevbare GA, Van Eerdenbrugh B, Box K, Sanchez-Felix MV, and Taylor LS.pH-Induced Precipitation Behavior of Weakly Basic Compounds – Determination of Extent and Duration of Supersaturation using Potentiometric Titration and Correlation to Solid State Properties. Pharmaceutical Research 29 (2012): 2738-2753.

Trasi NS and Taylor LS. Effect of Additives on Crystal Growth and Nucleation of Amorphous Flutamide. Crystal Growth and Design 12(6) (2012): 3221-3230.

Ilevbare GA, Liu H, Edgar KJ, and Taylor LS. Understanding Polymer Properties Important for Crystal Growth Inhibition – Impact of Chemically Diverse Polymers on Solution Crystal Growth of Ritonavir. Crystal Growth and Design 12(6) (2012): 3133-3143. 

Van Eerdenbrugh B, Lo M, Kjoller K, Marcott C, and Taylor LS. Nanoscale Mid-Infrared Evaluation of the Miscibility Behavior of Blends of Dextran or Maltodextrin with Poly(vinylpyrrolidone). Molecular Pharmaceutics 9(5) (2012): 1459-1469.

Kwok K and Taylor LS. Analysis of Counterfeit Cialis® Tablets Using Raman Microscopy and Multivariate Curve Resolution. Journal of Pharmaceutical and Biomedical Analysis 66 (2012): 126-135.

Kwok K and Taylor LS. Analysis of the Packaging Enclosing a Counterfeit Pharmaceutical Tablet using Raman Microscopy and Two-dimensional Correlation Spectroscopy. Vibrational Spectroscopy 161 (2012): 176-182.

Van Eerdenbrugh B, Lo M, Kjoller K, Marcott C, and Taylor LS. Nanoscale Mid-Infrared Imaging of Phase Separation in a Drug-Polymer Blend. Journal of Pharmaceutical Sciences 101(6) (2012): 2066-2073.

Kestur U S, Ivanisevic I, Alonzo DE, and Taylor LS. Influence of Particle Size on the Crystallization Kinetics of Amorphous Felodipine Powders. Powder Technology 236 (2012): 197-204.

Zhou Q, Harris MT, and Taylor LS. Modification of Crystallization Behavior in Drug/Polyethylene Glycol Solid Dispersions. Molecular Pharmaceutics 9(3) (2012): 546-553. 

Alonzo DE, Raina S, Zhou D, Gao Y, Zhang GGZ, and Taylor LS.  Characterizing the Impact of Hydroxypropylmethyl Cellulose on the Growth and Nucleation Kinetics of Felodipine from Supersaturated Solutions. Crystal Growth and Design 12(3) (2012): 1538-1547.

Van Eerdenbrugh B, and Taylor LS. Molecular Weight Effects on the Miscibility Behavior of Dextran and Maltodextrin with Poly(vinylpyrrolidone). Pharmaceutical Research 29 (2012): 2754-2765.

Weber RJK, Benmore CJ, Tumber SJ, Tailor AN, Rey CA, Taylor LS, and Byrn SR. Acoustic Levitation: Recent Developments and Emerging Opportunities in Biomaterials Research. Eur. Biophys J 41(4) (2012): 397-403. 

Baird JA, and Taylor LS. Evaluation of Amorphous Solid Dispersion Properties using Thermal Analytical Techniques. Advanced Drug Delivery Reviews 64(5) (2012): 396-421. 

Trasi NS, Fanwick PE, and Taylor LS. Nilutamide. Acta Crystallographica E 68(3) (2012): o591.

Baird JA, Santiago-Quinonez D, Rinaldi C, and Taylor LS.  Role of Viscosity in Influencing the Glass-forming Ability of Organic Molecules from the Undercooled Melt State. Pharm. Res 29(1) (2012): 271-284.

Lipasek RA, Ortiz JC, Taylor LS, and Mauer LJ. Effects of Anticaking Agents and Storage Conditions on the Moisture Sorption, Caking, and Flowability of Deliquescent Ingredients. Food Research International 45(1) (2012): 369-380. 

Curriculum Vitae

Click here for a full CV for Lynne S. Taylor. (an Adobe Acrobat file)