Department of Industrial and Physical Pharmacy Personnel - Lynne S. Taylor
Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions
EducationBachelor of Pharmacy with Honors, University of Bath, UK, 1990
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principle Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003
Research: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions
Our overall goal is to enhance drug delivery by optimizing and understanding the physicochemical properties of drugs and excipients. Of particular interest are amorphous solid dispersions which are used to improve the oral delivery of poorly water-soluble drugs, as well as pharmaceutical salts. For these types of solids, it is extremely important to understand drug-excipient interactions as well as the imapct of water on stability. We achieve an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques. Some of the analytical techniques that we use are infrared, Raman, ultraviolet and fluorescence spectroscopy, X-ray powder diffraction and differential scanning calorimetry.
Current Research Projects
Lab Members:Alireza Ghaffari (Visiting Scholar with Dr. Lynne Taylor)
Anura Suresh Indulkar (Graduate Student)
Matthew James Jackson (Graduate Student)
Laura Mosquera-Giraldo (Graduate Student)
Hitesh Shridev Purohit (Graduate Student)
Luis Filipe Ramalho de Almeida e Sousa (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Niraj Satish Trasi (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Venecia Rochelle Wilson (Graduate Student)
Tian Xie (Graduate Student)
Honors and Credentials
Pereira, J.M., Mejia-Ariza, R., Ilevbare, G.A., McGettigan, H.E., Sriranganathan, N., Taylor, L.S., Davis, R.M. and Edgar, K.J. (2013). Interplay of Degradation, Dissolution and Stabilization of Clarithromycin and its Amorphous Solid Dispersions, Molecular Pharmaceutics 10(12):4640-4653.
Lipasek, R.A., Li, N., Schmidt, S.J., Taylor, L.S., and Mauer, L.J. (2013). Effect of Temperature on the Deliquescence Properties of Food Ingredients and Blends, Journal of Agriculture and Food Chemistry 61(38):9241-9250.
Harrison A.J., Bilgili, E.A., Beaudoin, S.P. and Taylor, L.S. (2013). Atomic force microscope infrared spectroscopy of griseofulvin nanocrystals, Analytical Chemistry 85(23):11449-11455.
Kestur, U.S. and Taylor, L.S. (2013) Evaluation of the Crystal Growth Rate of Felodipine Polymorphs in the Presence and Absence of Additives as a Function of Temperature, Crystal Growth and Design 13(10):4349-4354.
Ilevbare, G.A., Liu, H., Pereira, J., Edgar, K.J., Taylor, L.S. (2013). Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir, Molecular Pharmaceutics 10: 3392-3403.
Li, N., Taylor, L.S., Ferruzzi, M.G. and Mauer, L.J. (2013). Color and Chemical Stability of Tea Polyphenol (-)-Epigallocatechin-3-gallate in Solution and Solid States, Food Research International 53:909-921.
Li, B., Konecke, S., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Both Solubility and Chemical Stability of Curcumin are Enhanced by Solid Dispersion in Cellulose Derivative Matrices, Cellulose 98: 1108-1116.
Ilevbare, G.A., Liu, H., Edgar, K. J., Taylor, L.S. (2013). Impact of Polymers on the Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution, Molecular Pharmaceutics 10(6):2381–2393.
Li, B., Liu, H., Amin, M., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Enhancement of Naringenin Solution Concentration by Solid Dispersion in Cellulose Derivative Matrices, Cellulose 20(4): 2137-2149.
Li, B., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Stability and Solubility Enhancement of Resveratrol in Spray Dried Solid Dispersion with Cellulose Derivative Matrices, Cellulose 20(3): 1249-1260.
Li, B., Konecke, S., Harich, K., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Solid Dispersion of Quercetin in Cellulose Derivative or PVP Matrix Influences both Solubility and Stability, Carbohydrate Polymers 92:2033-2040.
Malta, D.C., Kwok, K., Wang, P., Taylor, L.S. and Ben-Amotz, D. (2013). Rapid Classification of Pharmaceutical Ingredients with Raman Spectroscopy Using Compressive Detection Strategy with PLS-DA Multivariate Filters, Journal of Pharmaceutical and Biomedical Analysis 80:63-68.
Abbou-Oucherif, K., Raina, S., Taylor, L.S. and Litster, J.D. (2013). Quantitative Analysis of the Inhibitory Effect of HPMC on Felodipine Crystallization Kinetics Using Population Balance Modeling, CrystEngComm 15:2197-2205.
Christensen, N.P.A., Van Eerdenbrugh, B., Kwok, K., Taylor, L.S., Bond, A.D. Rades, T., Rantanen, J., Cornett, C. (2013). Rapid Insight into Heating-induced Phase Transformations in the Solid-state of the Calcium Salt of Atorvastatin using Multivariate Data Analysis, Pharmaceutical Research 30(3):826-835.
Kestur, U.S., Ivanisevic, I., Alonzo, D.E. and Taylor, L.S. (2013). Influence of Particle Size on the Crystallization Kinetics of Amorphous Felodipine Powders, Powder Technology 236:197–204.
Ilevbare, G.A., Liu, H., Edgar, K.J., Taylor, L.S. (2013). Maintaining Supersaturation in Aqueous Drug Solutions - Impact of Different Polymers on Induction Times, Crystal Growth and Design 13(2):740-751.
Zhou, Q., Toth, S.J., Simpson, G.J., Hsu H-Y., Taylor L.S., Harris, M.T., (2013). Crystallization and Dissolution Behavior of Naproxen/Polyethylene Glycol Solid Dispersions, Journal of Physical Chemistry 117(5):1494-1500.
Hsu, H-Y, Toth, S.J., Simpson, G.J., Taylor, L.S., Harris, M.T. (2013). Effect of Substrates on Naproxen\Polyvinylpyrrolidone Solid Dispersions Formed via the Drop Printing Technique, Journal of Pharmaceutical Sciences 102(2):638-648.
Wegiel, L.A., Mauer, L.J., Edgar, K.J., and Taylor, L.S. (2013). Crystallization of Amorphous Solid Dispersions of Resveratrol during Preparation and Storage – Impact of Different Polymers, Journal of Pharmaceutical Sciences 102(1):171-184.
Baird, J.A., Thomas, L.C., Aubuchon, S.R. and Taylor, L.S. (2013). Evaluating the Non-isothermal Crystallization Behavior of Organic Molecules from the Undercooled Melt State using Rapid Heat/Cool Calorimetry, CrystEngComm 15(1):111-119.
Li, B., Harich, K., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Stability and Solubility Enhancement of Ellagic Acid in Cellulose Ester Solid Dispersions, Carbohydrate Polymers 92:1443-1450.
Ilevbare, G. A. and Taylor, L. S. (2013). Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly-Water Soluble Drugs – Implications for Solubility Enhancing Formulations. Crystal Growth and Design. 13(4):1497-1509.
Liu, H., Ilevbare, G. A., Cherniawskia, B. P., Ritchie, E. T., Taylor, L. S. and Edgar, K. J. (2013). Synthesis and Structure-property Evaluation of Cellulose ω-carboxyesters for Amorphous Solid Dispersions. Carbohydrate Polymers.
Toth S.J., Madden J.T., Taylor L.S., Marsac P.J., and Simpson, G.J. (2012). Selective Imaging of Active Pharmaceutical Ingredients in Powdered Blends with Common Excipients Utilizing Two-Photon Excited Ultraviolet-Fluorescence and Ultraviolet-Second Order Nonlinear Optical Imaging of Chiral Crystals. Analytical Chemistry 84(14): 5859-5875.All publications for Lynne S. Taylor (an Adobe Acrobat file)
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This record was last updated on Jul 25, 2014 at 12:03 PM