Department of Industrial and Physical Pharmacy Personnel - Lynne S. Taylor
Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions
EducationBachelor of Pharmacy with Honors, University of Bath, UK, 1990
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principal Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003
Research: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions
Our overall goal is to enhance drug delivery by optimizing and understanding the physicochemical properties of drugs and excipients. Of particular interest are amorphous solid dispersions which are used to improve the oral delivery of poorly water-soluble drugs. We are also interested in the stability of pharmaceutical salts and the impact of excipients on product performance. For these types of solids, it is extremely important to understand drug-excipient interactions as well as the imapct of water on stability. We achieve an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques. Some of the analytical techniques that we use are infrared, Raman, ultraviolet and fluorescence spectroscopy, X-ray powder diffraction and differential scanning calorimetry.
Current Research Projects
Lab Members:Clara E. Correa Soto (Visiting Scholar)
Ahmed Elkhabaz (Graduate Student)
Anura Suresh Indulkar (Graduate Student)
Matthew James Jackson (Graduate Student)
Na Li (Post-Doctoral Research Associate with Dr. Lynne Taylor)
Jennifer Lu (Graduate Student)
Laura Mosquera-Giraldo (Graduate Student)
Turgay Polat (Visiting Scholar)
Hitesh Shridev Purohit (Graduate Student)
Chailu Que (Graduate Student)
Caitlin Schram (Graduate Student)
Bin Tian (Visiting Scholar)
Niraj Satish Trasi (Research Scientist)
Venecia Rochelle Wilson (Graduate Student)
Tian Xie (Graduate Student)
Honors and Credentials
Sato, T. and Taylor, L. S. (2015). Chiral Discrimination by a Cellulose Polymer: Differential Crystallization Inhibition of Enantiomers in Amorphous Dispersions. CrystEngComm. 17:5046-5053.
Schmitt, P. D., Trasi, N. S., Taylor, L. S. and Simpson, G. S. Finding the Needle in the Haystack – Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. (2015) Molecular Pharmaceutics. 12(7):2378-2383.
Nie, H., Mo, H., Zhang, M., Song, Y., Fang, K., Taylor, L. S., Li, T. and. Byrn, S. R. (2015). Investigating the interaction pattern and structural elements of a drug-polymer complex at the molecular level. Molecular Pharmaceutics. 12(7)2459-2468.
Trasi, N. S. and Taylor, L. S. (2015). Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs – Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products. Journal of Pharmaceutical Sciences. 104(8):2583-2593.
Indulkar, A., Box, K. J., Taylor, R., Ruiz, R., and Taylor, L. S. (2015). pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs. Molecular Pharmaceutics. 12(7):2365-2377.
Purohit, H. S. and Taylor, L. S. Phase Separation Kinetics in Amorphous Solid Dispersions Upon Exposure to Water. (2015) Molecular Pharmaceutics. 12(5):1623-1635.
Chen, J., Mosquera-Giraldo L., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015). Bile Salts as Crystallization Inhibitors of Supersaturated Solutions of Poorly Water-Soluble Compounds. Crystal Growth and Design. 15(6):2593-2597.
Raina, S. A., Van Eerdenbrug, B., Alonzo, D. E., Mo, H., Zhang, G. G. Z., Gao, Y. and Taylor, L. S. (2015). Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs Assessed using Synchrotron Radiation. Journal of Pharmaceutical Sciences. 104(6):1981-1992.
Içten, E., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2015). Dropwise Additive Manufacturing of Pharmaceutical Products for Melt-Based Dosage Forms. Journal of Pharmaceutical Sciences. 104(5):1641-1649.
Toth, S., Schmitt, P. D., Snyder, G. R., Trasi, N. S., George, I. A., Taylor, L. S. and Simpson, G. J. (2015) Ab Initio Prediction of the Diversity of Second Harmonic Generation from Pharmaceutically Relevant Materials. Crystal Growth Design. 15(2):581-586.
Chen, J., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015) Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles. Molecular Pharmaceutics. 12(2):533-541.
Trasi, N. S., Abbou-Oucherif, K., Litster, J. D. and Taylor, L. S. (2015) Evaluating the Influence of Polymers on Nucleation and Growth in Supersaturated Solutions of Acetaminophen. CrystEngComm. 17:1242-1248.
Mosquera-Giraldo L., and Taylor, L. S. (2015) Glass-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir. (2015) Molecular Pharmaceutics. 12(2):496-501.
Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2015). Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches. Molecular Pharmaceutics. 12(2):484-495.
Hsieh, Y-L., and Taylor, L. S. (2015). Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion. Pharmaceutical. Research. 32(2):549-561.
Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2015). Impact of Polymer Conformation on the Crystal Growth Inhibition of a Poorly Water Soluble Drug in Aqueous Solution. Langmuir. 31(1):171-179.
Hsu, H-Y, Adigun, O. O., Taylor, L. S., Murad, S. and Harris, M. T. (2015). Impact of Surface Chemistry on Crystallization of Acetaminophen. Chemical Engineering Science. 126:1-9.
Lipasek, R.A., Li, N., Taylor, L. S. and Mauer, L. J. (2015) Effect of temperature and initial moisture content on the chemical stability and color change of various forms of vitamin C. International Journal of Food Properties. 18(4):862-879.All publications for Lynne S. Taylor (an Adobe Acrobat file)
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This record was last updated on Aug 24, 2015 at 9:53 AM