Department of Industrial and Physical Pharmacy Personnel - Kinam Park

Kinam Park, PhD Professor of Pharmaceutics Showalter Distinguished Professor of Biomedical Engineering Phone: (765) 494-7759 Fax: (765) 496-1912 E-mail: kpark@purdue.edu Lab webpage: http://web.ics.purdue.edu/~kpark/ Full directory listing

Education

Research

Dr. Park has a dual appointment in IPPH and BioMedical Engineering (BME).  He keeps the most up-to-date listings of his research on a web page at: http://kinam.com.

Drug Delivery

• Polymer Micelles (delivery of poorly soluble drugs)
• Oral Formulations (fast-dissolving tablets & gastric retention devices)

Biomaterials

• Drug-eluting Stents & Drug-eluting Balloons
• Smart Polymers & Hydrogels

Representative Publications

Scott, R.A., Park, K., Panitch, A.: Water soluble polymer films for intravascular drug delivery of antithrombotic biomolecules, Eur. J. Pharm. Biopharm., in press.

Yun, Y. and Park, K.: Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery, Adv. Drug Del. Rev., in press.

Shin, C.S., Kwak, B., Han, B., and Park, K.: Development of an in vitro 3D tumor model to study therapeutic efficiency of an anti-cancer drug, Mol. Pharm., in press.

Lu, Y. and Park, K.: Polymeric micelles as delivery vehicles for poorly soluble drugs, Int. J. Pharm., in press.

Lee, S.C., Kwon, I.K. and Park, K.: Hydrogels for delivery of bioactive agents: a historical perspective, Adv. Drug Del. Rev., 65: 17-20, 2013.

Lee, S.Y., Kim, S.W., Tyler, J., Park, K., and Cheng J.-X.: Blood-stable, tumor-adaptable disulfide bonded MPEG-(Cys)4-PDLLA micelles for chemotherapy, Biomaterials, 34: 552-561, 2013.

Yoon, H.Y., Saravanakumar, G., Heo, R., Choi, S.H., Song, I.C., Han, M.H., Kim, K., Park, J.H., Choi, K., Kwon. I.C. and Park, K.: Hydrotropic magnetic micelles for combined magnetic resonance imaging and cancer therapy, J. Control. Release, 160: 692-698, 2012.

Yoon, H.Y., Koo, H., Choi, K.Y., Lee, S.J., Kim, K., Kwon, I.C., Leary, J.F., Park, K., Yuk, S.H. Park, J.H. and Choi, K.: Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy, Biomaterials, 33: 3980-3989, 2012.

Kwon, I.K., Lee, S.C., Han, B., and Park, K.: Analysis on the current status of targeted drug delivery to tumors, J. Control. Release, 164: 108-114, 2012.

Key, J., Cooper, C., Kim, A.Y., Dhawan, D., Knapp, D.W., Kim, K.M., Park, J.H., Choi, K.W., Kwon, I.C., Park, K., and Leary, J.F.: In vivo NIRF and MR dual-modality imaging using glycolchitosan nanoparticles, J. Control. Release, 163: 249-255, 2012.

Choi, K.Y., Saravanakumar, G., Park, J.H., and Park, K.: Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer, Colloids and Surfaces B: Biointerfaces, 99: 82-94, 2012.

Kim, D.Y., Kwon, D.Y., Lee, B.N., Seo H.W., Kwon, J.S., Lee, B., Han, D.K., Kim, J.H., Min, B.H., Park, K., and Kim, M.S.: Injectable in situ-forming hydrogels for a suppression of drug burst from drug-loaded microcapsules, Soft Matter, 8: 7638-7648, 2012.

Vedantham, K., Chaterji, S., Kim, S.W., and Park, K.: Development of a probucol-releasing anti-thrombogenic drug eluting stent, J. Biomed. Mater. Res. Part B:  Appl. Biomater.100B: 1068-1099, 2012.

Qiu, Y. and Park, K.: Environment-sensitive hydrogels for drug delivery, Advanced Drug Delivery Reviews, 53: 321-339, 2001.  64: 49-60, 2012.

Omidian. H. and Park, K.: Hdrogels, in Fundamentals and Applications of Controlled Release Drug Delivery, Juergen Siepmann, Ronald Siegel, and Michael Rathbone, Eds. Spinger, New York, NY, pp. 75-106, 2012.

Mastropietro, D., Omidian, H., and Park, K.: Drug delivery applications for superporous hydrogels, Expert Opinion on Drug Delivery,9: 71-89, 2012.

Lee, S.J., Koo, H., Lee, D.E., Min, S., Lee, S., Chen, X., Choi, Y., Leary, J.F., Park, K., Jeong, S.Y., Kwon, I.C., and Choi, K.: Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system, Biomaterials, 32: 4021-4029, 2011.

Bae, Y.H. and Park, K.: Targeted Drug Delivery to Tumors: Myths, Reality, and Possibility, J. Control. Release, 153: 198-205, 2011.

Kim, J.Y., Kim, S.W., Pinal, R., and Park, K.: Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs, J. Control. Release, 152: 13-20, 2011.

Park, Kyeongsoon, and Park, Kinam: Oral protein delivery: Current status and future prospect, Reactive and Functional Polymers, 71: 280-287, 2011.

Ye, M., Kim, S.W., and Park, K.: Issues in long-term protein delivery using biodegradable microparticles, J. Control. Release, 156: 241-260, 2010.

Kim, K., Kim, J.H., Park, H., Kim, Y.-S., Park, K.S., Nam, H., Lee, S., Park, J.H., Park, R.-W., Kim, I.-S., Choi, K., Kim, S.Y., Park, K. and Kwon, I.C.: Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring, J. Control. Release, 146: 219-227, 2010.

Acharya, G., Shin, C.S., Vedantham, K., McDermott, M., Rish, T., Hansen, K., Fu, Y. and Park, K.: A Study of Drug Release from Homogeneous PLGA microstructures, J. Control. Release,146: 201-206, 2010.

Acharya, G., Shin, C.S., McDermott, M., Mishra, H., Park, H., Kwon, I.C., and Park, K.: The hydrogel template method for fabrication of homogeneous nano/microparticles, J. Control. Release, 141: 314-319, 2010.

Saravanakumar, G., Choi, K.Y., Yoon, H.Y., Kim, K., Park, J.H., Kwon, I.C., Park, K.: Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel. Int. J. Pharm., 394: 154-161, 2010.

Kim, J.Y., Kim, S.W., Papp, M., Park, K., and Pinal, R.: Hydrotropic solubilization of poorly water-soluble drugs, J. Pharm. Sci. 99: 3953-3965, 2010.   

Shi, Y., Kim, S.W., Huff, T.B., Borgens, R.B., Park, K., Shi, R., and Cheng, J.-X.: Effective repair of traumatically injured spinal cord by nanoscale block copolymer micelles, Nature Nanotech, 5: 80-87, 2010.