Severin Thomas Schneebeli

Research in the Schneebeli group lies at the interface of industrial and physical pharmacy, supramolecular chemistry, organic synthesis, and multiscale computer modeling. The main aim of our research is to invent better methods to manufacture, stabilize, and deliver biopharmaceuticals. The Schneebeli lab develops next generation affinity reagents (artificial antibodies) and catalysts (artificial enzymes) based on unique precision macromolecular scaffolds to meet this challenge. We first design these functional systems with multiscale computer modeling, and then synthesize and test the systems in our lab. As a first example of artificial enzymes, we have recently reported a large and robust molecular tetrahedron, which can size-selectively functionalize polymer chains in Chem (Cell Press) . Graduate, undergraduate, and professional students in the Schneebeli group gain valuable interdisciplinary experience in industrial and physical pharmacy, organic synthesis, supramolecular chemistry, materials characterization, and computer modeling.

• Biopharmaceutical Production, Stabilization, and Delivery
• Supramolecular Chemistry
• New Affinity Reagents

• NIH MIRA Award 2022                           
• Thieme Chemistry Journals Award 2020
• NSF CAREER Award 2019
• Army Research Office Young Investigator Award 2018
• International Institute for Nanotechnology (IIN) Postdoctoral Fellowship, Awarded 2011–2013, for Demonstrated Innovation & Outstanding Achievement during the Doctoral Research
• ACS Postdoc to Faculty Workshop Travel Award, Indianapolis, IN 2013
• Selected Participant, NSF Future Faculty Workshop “Leaders of Tomorrow”, Atlanta, GA 2013
• DOE Travel Fellowship to attend the ISMSC-8 Conference in Arlington, VA 2013
• Hammett Award in Chemistry for Excellence in Studies and Research 2011
  toward the PhD, Columbia University, awarded to the top Fifth-year Chemistry Graduate Student
• Arun Guthikonda Memorial Fellowship in Chemistry, 2010–2011
  Columbia University, awarded to the top Fourth Year Chemistry Graduate Student
• Best Scientific Poster Award, Columbia University Nanoscale Science 2009
  and Engineering Center Retreat, Short Hills, NJ
• Upjohn Fellowship for Academic Excellence, Columbia University 2007–2008
• Appointed Young Researcher Participant, 18th Meeting of Nobel Prize Winners 2006
  in Chemistry, Lindau, Germany
• Scholarships from the Alfred Werner Legate at the University of Zurich, 2005/2006
  Switzerland, awarded for Academic Excellence
• Appointed Member of the Swiss National Team at the 34th International Chemistry 2002
  Olympiad, Groningen, the Netherlands for High School Researchers

List of publications