Sandro Matosevic

Assistant Professor
Specialization: Immunotherapy, cell therapy, bio-nanotechnology, cryopreservation, controlled delivery, biopharmaceutical engineering


The Scripps Research Institute - Postdoctoral Training, Chemistry
University College London - PhD, Biochemical Engineering
University College London and Rensselaer Polytechnic Institute - MEng with Study Abroad, Biochemical Engineering


Dr. Matosevic’s research program focuses on developing translational tools to control and direct the therapeutic behavior of immune cells and their interaction with the tumor microenvironment by combining approaches in cell therapy, gene engineering, nanotechnology and biomaterials to (1) Improve immune cell behavior against resistant cells via genetic and molecular modulation of their function; (2) Develop new nanoparticles to act as powerful nucleic acid, protein and drug nanotherapeutics and delivery systems to target immune system function; (3) Engineer novel biomaterial-based cryopreservation solutions devoid of DMSO to remove toxicity and improve safety associated with the post-thaw presence of DMSO. 

Lab Members

Andrea M. Chambers (Graduate Student with Dr. Sandro Matosevic)
Kyle B. Lupo (Graduate Student with Dr. Sandro Matosevic)
Jiao Wang (Post-Doctoral Research Associate with Dr. Sandro Matosevic)

Representative Publications

Pasley, Shannon, Zylberberg, Claudia; Matosevic, Sandro. Natural killer-92 cells maintain cytotoxic activity after long-term cryopreservation in novel DMSO-free media. Immunology Letters (2017), 192:35-4.

Zylberberg C, Gaskill K, Pasley S, Matosevic S. Engineering liposomal nanoparticles for targeted gene therapyGene Therapy, 2017, doi: 10.1038/gt.2017.41.

Zylberberg C and Matosevic S. Bioengineered liposome-scaffold composites as therapeutic delivery systems. Therapeutic Delivery, 2017, 8(6):425-445.

Zylberberg C and Matosevic S. Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. 2016, Drug Delivery, 23(9):3319-3329.

Knapinska A, Amar S, He Z, Matosevic S, Zylberberg C, Fields G. Matrix metalloproteinases as reagents for cell isolation. Enzyme and Microbial Technology, 2016,

Matosevic S, Paegel BM. Layer-by-layer cell membrane assembly. Nature Chemistry, 2013, 5:958-963.

Matosevic S. State-of-the-art in the development of microfluidic technology toward the synthesis of artificial cells from giant unilamellar vesicles. BioEssays, 2012, 34(11):992-1001.

Matosevic S, Paegel BM. 2011. Stepwise synthesis of giant unilamellar lipid vesicles on a microfluidic assembly line. Journal of the American Chemical Society, 2011, 133(9):2798-2800.

Matosevic S, Lye GJ, Baganz F. Immobilised enzyme microreactor for the quantification of multi-step bioconversions: Characterisation of a de novo transketolase-omega-transaminase pathway to synthesise chiral amino alcohols. Journal of Biotechnology2011, 155(3):320-329

Matosevic S, Szita N, Baganz F. Fundamentals and applications of immobilized enzyme microreactors. J Chem Tech Biotech.86(3):325-334.

Matosevic S, Lye GJ, Baganz F. Development and characterization of a prototype immobilized enzyme microreactor: Quantification of transketolase kinetics. Biotechnology Progress, 2010, 26(1):118-126.

Matosevic S, Micheletti M, Lye GJ, Baganz F. Quantification of kinetics for en-zyme-catalysed reactions: implications for enzyme diffusional limitations at the 10 ml scale. Biotechnology Letters, 2008, 30(6):995-1000.

Venkiteshwaran A, Heider P, Matosevic S, Bogsnes A, Staby A, Sharfstein S, Belfort G. 2007. Optimized Removal of Soluble Host Cell Proteins for the Recovery of met-Human Growth Hormone Inclusion Bodies from Escherichia coli Cell Lysate Using Crossflow Microfiltration. Biotechnology Progress, 23(3):667-672.

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