Site Director, Dane O. Kildsig Center for Pharmaceutical Processing Research
Post-doctoral Research: Environmental Sciences, University of Florida, 1988-1990
* Preformulation, Hoffmann-La Roche, 1990-1993
* Formulation, Sterile Products, Hoffmann-La Roche, 1993-1997
* Solid State Pharmaceutics, Hoffmann-La Roche, 1997-2003
Pinal research group (Back, l to r): Dr. Pinal, Geng Li, Evan Liechty, Mario Cano. (Front, l to r): Sandra Perez-Buitrago, Tiffany Marin Restrepo, Necla Mine Eren, Hwee Jing Ong
Dr. Pinal’s research interests include: solution chemistry, solubility and solubilization techniques, mixtures, polymer-based composites as means of control of product performance (mechanical strength, dissolution, release rate and bioavailability) of bioactive compounds, antiplasticization, and molecular relaxation in amorphous organic materials.
For more information, see:
IPPH 471 - Parenteral Products
IPPH 562 - Manufacturing Processes
IPPH 587 - Pharmaceutical Solids
IPPH 521 - Drug Development
IPPH 690A - Solids Discussion Group
IPPH 590 - Applied Thermodynamics
J.J. Carrascal, R. Pinal, T. Carvajal, L.D. Pérez and Y. Baena. Benzoic acid complexes with Eudragit E100: New alternative antimicrobial preservatives. Int. J. Pharm. 607, 120991 (2021).
M.A. Cano-Vega, M. Deng and R. Pinal. Modular solid dosage form design – Application to pH-independent release of a weak-base API. Int. J. Pharm. 601, 120518 (2021).
Hadar, J., Skidmore, S. Garner, G., Park, H., Park, K., Wang. Y., Qin, B., Jiang, X.J., and Kozak, D.: Method matters: Development of characterization techniques for branched and glucose-poly(lactide-co-glycolide) polymers, J. Control. Release, 320: 484-494, 2020.
Sharifi, F., Otte, A., Yoon, G., and Park K.: Continuous in-line homogenization process for scale-up production of naltrexone-loaded PLGA microparticles, J. Control. Release, 325: 347-358, 2020.
Otte, A., Sharifi, F., and Park K.: Interfacial tension effects on the properties of PLGA microparticles, Colloids and Surfaces B: Biointerfaces, 196: 111300 (6 pages), 2020.
Bae, Y.H. and Park, K.: Advanced drug delivery 2020 and beyond: Perspectives on the future, Adv. Drug Del. Rev., 158: 4-16, 2020.
R. Pinal and M. T. Carvajal. Integrating particle microstructure, surface and mechanical characterization with bulk powder processing. KONA Powder and Particle Journal (2020), 37:195–213.
Hwee Jing Ong and Rodolfo Pinal. Drug Solubilization by Means of Partition/Association Equilibrium Using a Modified Nanosized Dendrimeric Biopolymer. AAPS PharmSciTech (2019) 20 (304):1-13.
H. J. Ong and R. Pinal. Drug solubilization by means of a surface-modified edible biopolymer enabled by hot melt extrusion. Journal of Pharmaceutical Sciences. 107, 402-411 (2018).
T. Marín, P. Montoya, O. Arnache, R. Pinal, J. Calderón. Bioactive films of zein/magnetite magnetically stimuli-responsive for controlled drug release. Journal of Magnetism and Magnetic Materials. 458, 355-364 (2018).
D. Cebeci-Maltas, R. Pinal, L. Taylor and D. Ben-Amotz, Spatial light modulators as PAT sensors: Raman applications. European Pharmaceutical Review. 23, 72-74 (2018).
D. Cebeci-Maltas D. Ben-Amotz, M. A. Alam, P. Wang and R. Pinal. Photobleaching profile of Raman peaks and fluorescence background. Eur. Pharm. Rev. Issue 6 (2017).
Y. Song, D. Zemlyanov, X. Chen, Z. Su, H. Nie, J.W. Lubach, D.Smith, S. Byrn and R. Pinal. Acid-base interactions in amorphous solid dispersions of lumefantrine prepared by spray-drying and hot-melt extrusion using X-ray photoelectron spectroscopy. Int. J. Pharm. 514, 456-464 (2016).
E.A Münchow, H.J. Hammann, M.T, Carvajal, R. Pinal, and M.C. Bottino. Stain removal effect of novel papain- and bromelain-containing gels applied to enamel. Clin. Oral Invest. 20, 2315–2320 (2016).
D. Cebeci-Maltas, R. McCann, P. Wang, R. Pinal, R. Romanach and D. Ben-Amotz. Pharmaceutical application of fast Raman hyperspectral imaging with compressive detection strategy. Journal of Pharmaceutical Innovation. 9, 1-4 (2014).
H. M. Fadda, X. Chen, A. Aburub, D. Mishra and R. Pinal. A novel method for determining the solubility of small molecules in aqueous media and polymer solvent systems using solution calorimetry. Pharmaceutical Research. 31, 1735-1743 (2014).
K. Boksa, A. Otte and R. Pinal. Matrix-Assisted Cocrystallization (MAC): Simultaneous production and formulation of pharmaceutical cocrystals by hot-melt extrusion. Journal of Pharmaceutical Sciences. 103, 2904-2910 (2014).
Organized polysaccharide fibers as stable drug carriers. Janaswamya, S, Gill, KL, Campanella, OH, and Pinal, R. Carbohyd. Polym. 94: 209-215 (2013).
Milling induces disorder in crystalline griseofulvin and order in its amorphous counterpart. Otte, A, Zhang, Y, Carvajal MT, and Pinal R. Cryst. Eng. Comm. 14 (2012): 2560-2570.
Mechanisms of epi-detected stimulated Raman scattering microscopy. Wang, P, Slipchenko, MN, Zhou, B, Pinal R, and Cheng, J. IEEE J. Sel. Topics Quant. Electron 18 (2012): 384-388.
The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments. Lee EH, Byrn SR, Pinal R. J Pharm Sci. 2012 Dec;101(12):4529-39. doi: 10.1002/jps.23316. Epub 2012 Sep 12.
Development of novel microprecipitated bulk powder (MBP) technology for manufacturing stable amorphous formulations of poorly soluble drugs. Shah N, Sandhu H, Phuapradit W, Pinal R, Iyer R, Albano A, Chatterji A, Anand S, Choi DS, Tang K, Tian H, Chokshi H, Singhal D, Malick W. Int J Pharm. 2012 Nov 15;438(1-2):53-60. doi: 10.1016/j.ijpharm.2012.08.031. Epub 2012 Aug 29.
Complementary near-infrared and Raman chemical imaging of pharmaceutical thin films. Rozo JI, Zarow A, Zhou B, Pinal R, Iqbal Z, Romañach RJ. J Pharm Sci. 2011 Nov;100(11):4888-95. doi: 10.1002/jps.22653. Epub 2011 Jun 7.
Improvement of the dissolution rate of poorly soluble drugs by solid crystal suspensions. Thommes M, Ely DR, Carvajal MT, Pinal R. Mol Pharm. 2011 Jun 6;8(3):727-35. Epub 2011 Mar 28.
Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs. Kim JY, Kim S, Pinal R, Park K. J Control Release. 2011 May 30;152(1):13-20. Epub 2011 Feb 23.
Hydrotropic solubilization of poorly water-soluble drugs. Kim JY, Kim S, Papp M, Park K, Pinal R. J Pharm Sci. 2010 Sep;99(9):3953-65.
Solubility enhancement of hydrophobic compounds by cosolvents: role of solute hydrophobicity on the solubilization effect. Miyako Y, Khalef N, Matsuzaki K, Pinal R. Int J Pharm. 2010 Jun 30;393(1-2):48-54. Epub 2010 Apr 2.
The effect of dehydration conditions on the functionality of anhydrous amorphous raffinose. Chamarthy SP, Khalef N, Trasi N, Bakri A, Carvajal MT, Pinal R. Eur J Pharm Sci. 2010 Jun 14;40(3):171-8. Epub 2010 Mar 16.
Limitations of amorphous content quantification by isothermal calorimetry using saturated salt solutions to control relative humidity: alternative methods. Khalef N, Pinal R, Bakri A. J Pharm Sci. 2010 Apr;99(4):2080-9.
Solubility of hydrophobic compounds in water-cosolvent mixtures: relation of solubility with water-cosolvent interactions. Miyako Y, Zhao Y, Takeshima K, Kataoka T, Handa T, Pinal R. J Pharm Sci. 2010 Jan;99(1):293-302.
Theoretical and experimental considerations on the enthalpic relaxation of organic glasses using differential scanning calorimetry. Mao C, Chamarthy SP, Byrn SR, Pinal R. J Phys Chem B. 2010 Jan 14;114(1):269-79.