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CPPR Projects

C. Peroza Meza, M.A. Santos, and R.J. Romanach, "Quantitation of drug content in a low dosage formulation by Transmission Near Infrared Spectroscopy", 2006, 7(1), Article 29 (http://www.aapspharmscitech.org).

Dane O. Kildsig, Purdue University:

V. Swaminathan and D.O. Kildsig, "The Effect of Particle Morphology on the Physical Stability of Pharmaceutical Powder Mixtures: The Effect of Surface Roughness of the Carrier on the Stability of Ordered Mixtures", Drug. Dev and Indus. Pharm., 26(4), 365-373 (2000)

V. Swaminathan and D. O. Kildsig. An Examination of the Moisture Sorption characteristics of commercial Magnesium Stearate. AAPS PharmSciTech, 2001, Issue 4.

V. Swaminathan and D.O. Kildsig. Polydisperse Powder Mixtures: Effect of Particle size and Shape on Mixture Stability, Drug Development and Industrial Pharmacy, 2002, 28 (1).

V. Swaminathan and D.O Kildsig. Effect of Particle Morphology on the Physical Stability of Pharmaceutical Powder Mixtures: Effect of surface roughness of the carrier on the stability of ordered mixtures, Drug Development and Industrial Pharmacy, 2000, 26 (4), 365-373.

Evone Ghaly, University of Puerto Rico

Wu, Y.; Kildsig, D.O.; Ghaly, E.S. Effect of Hydrodynamic Environment on Tablets Dissolution Rate. Pharm. Dev. Technol. 9 (1), 25-37 (2004).

Donoso, M.; Kildsig, D.O.; Ghaly, E.S. Prediction of Tablet Hardness and Porosity Using Near-Infrared Diffuse Reflectance Spectroscopy as a Nondestructive Method. Pharm. Dev. Technol. 8 (4), 357-366 (2003).

Sepulveda, E.; Kildsig, D.O.; Ghaly, E.S. Relationship Between Internal Phase Volume and Emulsion Stability: The Cetyl Alcohol/Stearyl Alcohol System. Pharm. Dev. Technol. 8 (3), 263-275 (2003).

Donoso, M.; Ghaly, E.S. Prediction of Drug Dissolution from Tablets Using Near-Infrared Diffuse Reflectance Spectroscopy as a Nondestructive Method. Drug Dev. Technol: In Press

Wu, Y.; Ghaly, E.S. Effect of Hydrodynamic Environment on Tablet Dissolution Using Flow-Through Dissolution Apparatus. Pharm. Dev. Technol: Submitted.

Rodolfo J. Romañach - University of Puerto Rico:

J. Colón Soto, C. Peroza Meza, W. Caraballo, C. Conde, T. Li, K. R. Morris3, and R. J. Romañach, "On Line Non- Destructive Determination of Drug Content in Moving Tablets Using Near Infrared Spectroscopy", Journal of Process Analytical Technology, 2005, 2(5), 8 -15.

R.J. Romañach and M.A. Santos, "Content Uniformity Testing with Near Infrared Spectroscopy", American Pharmaceutical Review, 2003, 6(2), 62 67.

Jennifer Curtis Sinclair-Purdue University:

M. E. Lasinski, J. S. Curtis, and J. F. Pekny, "Effect of System Size on Particle-Phase Stress and Microstructure Formation", Physics of Fluids, 16 (2), 2004, 265-273.

Kenneth R. Morris, Purdue University:

Davis, T.D., Peck, G. E., Stowell, J.G., Morris, K.R. and Byrn, S.R., Modeling and Monitoring of Polymorphic Transformations During the Drying Phase of Wet Granulation, Pharmaceutical Research, 21 (5): 860-866) (2004).

Morris, K. R., Nail, S. L., Peck, G. E., Byrn, S. R., Griesser, U. J., Sotwell, J. G., Hwang, S-J, and Park, K. Advances in pharmaceutical materials and processing. Pharmaceutical Science and Technology Today. 1 (6):235-245 (Sept. 1998).

Morris, K. R., Schlam, R.F., Cao, W., and Short, M. S. Determination of average crystallite shape by X-ray diffraction and computational methods. Journal of Pharmaceutical Sciences. 89 (11):1432-1442 (2000). Published online Journal of Pharmaceutical Sciences (15 September 2000).

Li, T., Morris, K. R., and Park, K. Influence of solvent and crystalline supramolecular structure on the formation of etching patterns on acetaminophen single crystals. a study with atomic force microscopy and computer simulation. Journal of Physical Chemistry B. 104:2019-2032 (2000).

Li, T., Morris, K., and Park, K. Influence of tailor-made additives on the formation of etching patterns of acetaminophen single crystals. Poster presentation: AAPS National Meeting, Indianapolis, IN, October 2000.

Te, R. L., Griesser, U. J., Morris, K. R., Byrn, S. R., and Stowell, J. G. X-ray diffraction and Solid-State NMR Investigation of the Single-Crystal to Single-Crystal Dehydration of Thiamine Hydrochloride Monohydrate. Crystal Growth & Design. 3 (6):997-1004 (2003). Published online Crystal Growth & Design (15 August, 2003).

Davis, T. D., Morris, K. R., Huang, H., Peck, G. E., Stowell, J. G., Eisenhauer, B. J., Hilden, J. L., Gibson, D., and Byrn, S. R. In situ monitoring of wet granulation using online X-ray powder diffraction. Pharmaceutical Research. 20 (11):1851-1857 (2003) .