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Department of Industrial and Physical Pharmacy Personnel - Qi (Tony) Zhou

Qi (Tony) Zhou, PhD
Assistant Professor, Industrial and Physical Pharmacy
Phone: 765-496-0707
Fax: 765-494-6545
E-mail: tonyzhou@purdue.edu

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Picture of Qi (Tony) Zhou
Specialization: pharmaceutical manufacturing of solid dosage forms, particle engineering, powder technology, inhalation formulation, pulmonary drug delivery system, dry powder inhaler

Education

2011-2015 Postdoctoral Research Fellow, University of Sydney, Australia
2007-2011 PhD in Pharmacy, Monash University, Australia
2004-2008 MSc in Pharmacy, National University of Singapore, Singapore
1997-2001 BEng in Pharmaceutics, Shenyang Pharmaceutical University, China

Research: pharmaceutical manufacturing of solid dosage forms, particle engineering, powder technology, inhalation formulation, pulmonary drug delivery system, dry powder inhaler

Dr. Zhou’s research focuses on: (1) particle engineering for advanced pharmaceutical manufacturing of solid dosage forms; (2) novel formulation design for pulmonary drug delivery systems.

(1) Innovation is in great demand in pharmaceutical manufacturing aiming to improve the production efficiency of traditional small-molecule pharmaceutical products and to design suitable formulation for new biopharmaceutical entities. Dr Zhou’s research is to apply novel particle engineering techniques such as spray drying and dry coating to design efficient manufacture process for solid dosage forms of both small- and large-molecule pharmaceuticals. 

(2) Inhalation products become popular for treatment of pulmonary diseases because they can deliver the therapeutics directly to the site of diseases with potentially minimized systemic side effects and maximized treatment efficacy. Dr Zhou’s research is to design smart inhalation formulations for improved treatment of critical pulmonary diseases such as asthma, COPD and lung infection.   

Lab Members:

Sonal V. Bhujbal (Graduate Student)
Junhong Ling (Visiting Scholar with Dr. Tony Zhou)
Heejun Park (Visiting Scholar with Dr. Zhou)
Nivedita J. Shetty (Graduate Student)
Shaoning Wang (Visiting Scholar with Dr. Tony Zhou)
Shihui Yu (Visiting Scholar with Dr. Tony Zhou)

Honors and Credentials

2015 Postdoctoral Fellow Award, American Association of Pharmaceutical Scientists (AAPS)

2014 Australian Endeavor Fellowship, Australian Government

2013 Australian Biomedical Early Career Fellowship, NHMRC

Representative Publications

Zhou, Q.T., Qu, L., Chan, H.K. Pulmonary delivery of antibiotics for respiratory infections. Chapter 7 in Advances in Pulmonary Drug Delivery, Kwok, P.C.L. and Chan, H.K. (Ed.). CRC Press/Taylor & Francis Group, Boca Raton, FL, 2016. pp. 131-150.

Zhou, Q.T., Loh, Z.H., Yu, J.Q., Sun, S., Gengenbach, T., Denman, J., Li, J., Chan, H.K. How much surface coating of hydrophobic azithromycin is sufficient to prevent moisture-induced decrease in aerosolisation of hygroscopic colistin powder? 2016, AAPS Journal, 18(5), 1213-1224.

Schneider, E., Azad, M., Han, M., Zhou, Q., Wang, J., Huang, J., Cooper, M., Doi, Y., Baker, M., Bergen, P., Muller, M., Li, J., Velkov, T. An ‘unlikely’ pair: The antimicrobial synergy of polymyxin B in combination with the cystic fibrosis trans-membrane conductance regulator drugs KALYDECO and ORKAMBI. 2016, ACS Infectious Diseases, 2(7), 478-488. 

Leung, C.M.S., Tong, Z., Zhou, Q.T., Chan, J.G.Y., Tang, P., Sun, S., Yang, R., Chan, H.K. Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-based DPI Formulations. Part 1: Grid Structure. 2016, AAPS Journal, 18(5), 1159-1167.

Qu, L., Morton, D.A.V., Zhou, Q.T., Particle Engineering by Practical and Scalable Intensive Mechanical Dry Coating Processes to Develop Highly-Efficient Dry Powder Inhaler Formulations. 2016, Inhalation, 10(3), 17-22.

Jong, T., Li, J., Morton, D.A.V., Zhou, Q.T., Larson, I. Investigation of the changes in aerosolization behavior between the jet-milled and spray-dried colistin powders through surface energy characterization. 2016, Journal of Pharmaceutical Sciences, 105(3), 1156–1163.

Wang, W. , Zhou, Q.T. , Sun S., Denman J., Gengenbach, T., Barraud, N., Rice, S.A., Li, J., Yang, M., Chan, H.K. Effects of surface composition on the aerosolisation and dissolution of inhaled antibiotic combination powders consisting of colistin and rifampicin. 2016, AAPS Journal, 18(2) 372-384.

Jin, L., Zhou, Q.T., Chan, H.K., Larson, I., Pennington, W.M., Boyd, J.B., Norton, S.R., Nicolazzo, A.J. Pulmonary delivery of the Kv1.3-blocking peptide HsTX1[R14A] for the treatment of autoimmune diseases, 2016, Journal of Pharmaceutical Sciences, 105(2), 650–656. (Most Original and Most Significant Scientific Findings)

Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. Human Oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins, 2016, Journal of Antimicrobial Chemotherapy. 71 (2), 403-412. 

Jong, T., Li, J., Morton, D.A.V.,* Zhou, Q.T.,* Larson, I.* Investigation of the changes in aerosolization behavior between the jet-milled and spray-dried colistin powders through surface energy characterization. Journal of Pharmaceutical Sciences, accepted 4th Dec 2015 (* co-corresponding authors).

Wang, W. †, Zhou, Q.T. †, Sun S., Denman J., Gengenbach, T., Barraud, N., Rice, S.A., Li, J., Yang, M., Chan, H.K. Effects of surface composition on the aerosolisation and dissolution of inhaled antibiotic combination powders consisting of colistin and rifampicin. AAPS Journal, accepted 16th Nov 2015 († co-first authors).  

Jin, L., Zhou, Q.T., Chan, H.K., Larson, I., Pennington, W.M., Boyd, J.B., Norton, S.R., Nicolazzo, A.J. Pulmonary delivery of the Kv1.3-blocking peptide HsTX1[R14A] for the treatment of autoimmune diseases. Journal of Pharmaceutical Sciences, Accepted 22nd Oct 2015.

Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. Human Oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins, 2015, accepted 20th September, Journal of Antimicrobial Chemotherapy.  

Qu, L., Morton, D.A.V.*, Zhou, Q.T.* Particle engineering via mechanical dry coating in the design of pharmaceutical solid dosage forms, 2015, accepted 8th September, Current Pharmaceutical Design. (* co-corresponding authors).  

Leung, S.S.Y., Tang, P., Zhou, Q.T., Tong, Z., Leung, C., Decharaksa, J., Yang, R., Chan, H.K. De-agglomeration effect of the United States Pharmacopeia and Alberta throats on carrier-based powders in commercial inhalation products, 2015, AAPS Journal. 17 (6), pp. 1407-1416. 

Lin, Y., Wong, J., Chan, H. K.*, Zhou, Q. T.* Powder production and particle engineering for dry powder inhaler formulations, 2015, Current Pharmaceutical Design. 21(27), pp. 3902-3916. (* co-corresponding authors).  

Qu, L., Zhou, Q.T., Denman, J., Stewart, P.J., Hapgood, K., Morton, D.A.V. Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders, 2015, European Journal of Pharmaceutical Sciences.78, pp. 264–272.

Zhou, Q. T., Sun, S.; Chan, J., Wang, P., Barraud, N., Rice, S., Wang, J., Li, J., Chan, H. K. A novel inhaled combination powder containing amorphous colistin and crystalline rifapentine with enhanced antimicrobial activities against planktonic cells and biofilm of Pseudomonas aeruginosa for respiratory infection. 2015. Molecular Pharmaceutics. 12 (8), pp. 2594–2603. 

Velkov, T., Abdulrahim, N., Zhou, Q.T., Chan, H.K., Li, J., Inhaled chemotherapy with antibiotics, antivirals and antifungals. 2015. Advanced Drug Delivery Reviews 85, pp. 65-82.

Zhou, Q.T., Leung, S.S.Y., Tang, P., Thaigarajan, P., Loh Z.H., Chan, H.K., Inhalation formulation and drug delivery systems for respiratory infections. 2015. Advanced Drug Delivery Reviews 85, pp. 83-99.

Qu, L., Zhou, Q.T., Gengenbach, T., Denman, J., Hapgood, K., Gamlen, M., Stewart, P.J., Morton, D.A.V., Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. 2015. Drug Development and Industrial Pharmacy 41 (5), pp. 825-837.

Liang, W., Lau, P.N.N., Zhou, Q.T., Chow, M.Y.T., Kwok, P.C.L., Leung, G.P.H., Mason, A.J., Chan, H.K., Poon, L.L.M., Lam, J.K.W., Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza. 2015. Molecular Pharmaceutics 12 (3), pp. 910 -921. 

Rajkhowa, R., Abdullah, K., Zhou Q.T., Kondor A., Morton D.A.V., Wang X. Relationship between processing, surface energy and bulk properties of ultrafine silk particles. 2015. Powder Technology 270, pp. 112-120. 

Zhou, Q.T., Tang, P., Leung, S.S.Y., Chan, J.G.Y., Chan, H.K., Emerging inhalation aerosol devices and strategies: where are we headed? 2014. Advanced Drug Delivery Reviews, 75, pp. 3-17.

Chan, J.G.Y., Wong, J., Zhou, Q.T., Leung, S.S.Y., Chan, H.K., Advances in device and formulation technologies for pulmonary drug delivery. 2014. AAPS PharmSciTech, 15(4), pp. 882-897. 

Zhou, Q.T., Gengenbach, T., Denman, J. A., Yu, H. H., Li, J., Chan, H.K. Synergistic antibiotic combination powders of colistin and rifampicin provide high aerosolization efficiency and moisture protection. 2014. AAPS journal, 16(1), pp. 38-47. 

Zhou, Q.T., Morton, D. A.V., Yu, H. H., Jacob, J., Wang, J., Li, J., Chan, H.K. Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. 2013. Journal of Pharmaceutical Sciences, 102 (10), pp. 3736-3747. 

Zhou, Q.T., Tong, Z., Tang, P., Yang, R., Chan, H.K. Effect of device design on the aerosolization of a carrier-based dry powder inhaler- A case study on Aerolizer Foradile. 2013. AAPS journal, 15 (2), pp. 511-522.

Zhou, Q.T.*, Li, Qu, Gengenbach, T., Larson, I., Stewart, P.J., Morton, D.A.V.* Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. 2013. AAPS PharmSciTech, 14, pp. 38-44. (* co-corresponding authors).  

Zhou, Q.T., Morton, D.A.V. Drug-Lactose Binding Aspects in Adhesive Mixtures: Controlling performance in Dry Powder Inhaler Formulations by Altering Lactose Carrier Surfaces. 2012. Advanced Drug Delivery Reviews, 64 (3), pp. 275-284. 

Rajkhowa, R., Zhou, Q., Tsuzuki, T., Morton D.A.V., Wang, X., Ultrafine wool powders and their bulk properties. 2012. Powder Technology, 224 (3), pp. 183-188.

Zhou, Q.T., Gengenbach, T., Denman, J., Das, S., Li, Qu, Zhang H.L., Larson, I., Stewart, P.J., Morton, D.A.V. Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach, 2011. Journal of Pharmaceutical Sciences, 100 (8), pp. 3421-3430.

Zhou, Q.T., Li, Qu, Larson, I., Stewart, P.J., Morton, D.A.V. Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: a model cohesive pharmaceutical powder. 2011. Powder Technology, 207 (1-3), pp. 414-427.

Zhou, Q.T., Li, Qu, Gengenbach, T., Denman, J., Larson, I., Stewart, P.J., Morton, D.A.V. Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. 2011. International Journal of Pharmaceutics, 413 (1-2), pp. 36-43.

Das, S.C., Zhou, Q., Morton, D.A.V., Larson, I., Stewart, P.J. Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. 2011. European Journal of Pharmaceutical Sciences, 43 (4), pp. 325-333. 

Zhou, Q., Armstrong, B., Larson, I., Stewart, PJ., Morton D.A.V., Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. 2010. Journal of Pharmaceutical Sciences, 99 (2), pp. 969-981. 

Zhou, Q.T., Armstrong, B., Larson, I., Stewart, P.J., Morton, D.A.V., Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders. 2010. European Journal of Pharmaceutical Sciences, 40 (5), pp. 412-421.

Zhou, Q.T., Li, Qu, Larson, I., Stewart, P.J., Morton, D.A.V. Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach. 2010. International Journal of Pharmaceutics, 394 (1-2), pp. 50-59.

Zhou, Q., Armstrong, B., Larson, I., Stewart, PJ., Morton D.A.V., Effect of host particle size on the modification of powder flow behaviours of lactose monohydrate following dry coating. 2010. Dairy Science and Technology, 90 (2-3), pp. 237-251.  

Zhu, K., Tan, R.B.H., Kiong Ng, W., Shen, S., Zhou, Q., Heng, P.W.S. Analysis of the influence of relative humidity on the moisture sorption of particles and the aerosolization process in a dry powder inhaler. 2008. Journal of Aerosol Science, 39 (6), pp. 510-524.

Chan, L.W., Zhou, Q., Heng, P.W.S. Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers. 2007. Journal of Drug Delivery Science and Technology, 17 (3), pp. 217-222.

Karande, A. D., Zhou, Q., Chan, L. W., Heng, P. W. S. and Liew, C. V. Scanning Probe Microscopy for Surface Roughness Characterization of Lactose Carriers Used in Dry Powder Inhalation Therapy. 2007. Journal of scanning probe microscopy, 2, pp. 5-9.

Full publication list: https://scholar.google.com/citations?user=KrwU6bQAAAAJ&hl=en

Curriculum Vitae

Click here for a full CV for Qi (Tony) Zhou. (an Adobe Acrobat file)

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