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Department of Industrial and Physical Pharmacy Personnel - Rodolfo Pinal

Rodolfo Pinal, PhD
Associate Professor of Industrial and Physical Pharmacy
Director, Dane O. Kildsig Center for Pharmaceutical Processing Research
Phone: 765-496-6247
Fax: 765-494-6545
E-mail: rpinal@purdue.edu
Lab webpage: http://openwetware.org/wiki/Pinal_lab

Full directory listing
Picture of Rodolfo Pinal
Specialization: Drug solubility and solubilization. Strategies for enhancing the bioavailability of poorly soluble drugs.

Education

PhD, Pharmaceutical Sciences: University of Arizona, 1988
Post-doctoral Research: Environmental Sciences, University of Florida, 1988-1990
Industrial Experience:
* Preformulation, Hoffmann-La Roche, 1990-1993
* Formulation, Sterile Products, Hoffmann-La Roche, 1993-1997
* Solid State Pharmaceutics, Hoffmann-La Roche, 1997-2003

Research: Drug solubility and solubilization. Strategies for enhancing the bioavailability of poorly soluble drugs.

Pinal Research Group 2011

Pinal research group (l to r): Dr. Pinal, Kevin Boksa, Alok Sharma, Yan Zhang, Ning Zhu,

Andrew Otte

Dr. Pinal’s research interests include: solution chemistry, solubility and solubilization techniques, mixtures, polymer-based composites as means of control of product performance (mechanical strength, dissolution, release rate and bioavailability) of bioactive compounds, antiplasticization, and molecular relaxation in amorphous organic materials.

For more information, see:

Lab Members:

Hwee Jing Ong (Graduate Student)
Andrew David Otte (Post-Doctoral Research Associate with Dr. Rodolfo Pinal)

Teaching

IPPH 471 - Parenteral Products

IPPH 562 - Manufacturing Processes

IPPH 587 - Pharmaceutical Solids

IPPH 521 - Drug Development

IPPH 690A - Solids Discussion Group

IPPH 590 - Applied Thermodynamics

Representative Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=pinal%2C+rodolfo

Organized polysaccharide fibers as stable drug carriers. Janaswamya, S, Gill, KL, Campanella, OH, and Pinal, RCarbohyd. Polym. 94: 209-215 (2013).

Milling induces disorder in crystalline griseofulvin and order in its amorphous counterpart. Otte, A, Zhang, Y, Carvajal MT, and Pinal R. Cryst. Eng. Comm. 14 (2012): 2560-2570.

Mechanisms of epi-detected stimulated Raman scattering microscopy. Wang, P, Slipchenko, MN, Zhou, B, Pinal R, and Cheng, J. IEEE J. Sel. Topics Quant. Electron 18 (2012): 384-388.

The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments. Lee EH, Byrn SR, Pinal R. J Pharm Sci. 2012 Dec;101(12):4529-39. doi: 10.1002/jps.23316. Epub 2012 Sep 12.

Development of novel microprecipitated bulk powder (MBP) technology for manufacturing stable amorphous formulations of poorly soluble drugs. Shah N, Sandhu H, Phuapradit W, Pinal R, Iyer R, Albano A, Chatterji A, Anand S, Choi DS, Tang K, Tian H, Chokshi H, Singhal D, Malick W. Int J Pharm. 2012 Nov 15;438(1-2):53-60. doi: 10.1016/j.ijpharm.2012.08.031. Epub 2012 Aug 29.

Complementary near-infrared and Raman chemical imaging of pharmaceutical thin films. Rozo JI, Zarow A, Zhou B, Pinal R, Iqbal Z, Romañach RJ. J Pharm Sci. 2011 Nov;100(11):4888-95. doi: 10.1002/jps.22653. Epub 2011 Jun 7.

Improvement of the dissolution rate of poorly soluble drugs by solid crystal suspensions. Thommes M, Ely DR, Carvajal MT, Pinal R. Mol Pharm. 2011 Jun 6;8(3):727-35. Epub 2011 Mar 28.

Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs. Kim JY, Kim S, Pinal R, Park K. J Control Release. 2011 May 30;152(1):13-20. Epub 2011 Feb 23.

Hydrotropic solubilization of poorly water-soluble drugs. Kim JY, Kim S, Papp M, Park K, Pinal R. J Pharm Sci. 2010 Sep;99(9):3953-65.

Solubility enhancement of hydrophobic compounds by cosolvents: role of solute hydrophobicity on the solubilization effect. Miyako Y, Khalef N, Matsuzaki K, Pinal R. Int J Pharm. 2010 Jun 30;393(1-2):48-54. Epub 2010 Apr 2.

The effect of dehydration conditions on the functionality of anhydrous amorphous raffinose. Chamarthy SP, Khalef N, Trasi N, Bakri A, Carvajal MT, Pinal R. Eur J Pharm Sci. 2010 Jun 14;40(3):171-8. Epub 2010 Mar 16.

Limitations of amorphous content quantification by isothermal calorimetry using saturated salt solutions to control relative humidity: alternative methods. Khalef N, Pinal R, Bakri A. J Pharm Sci. 2010 Apr;99(4):2080-9.

Solubility of hydrophobic compounds in water-cosolvent mixtures: relation of solubility with water-cosolvent interactions. Miyako Y, Zhao Y, Takeshima K, Kataoka T, Handa T, Pinal R. J Pharm Sci. 2010 Jan;99(1):293-302.

Theoretical and experimental considerations on the enthalpic relaxation of organic glasses using differential scanning calorimetry. Mao C, Chamarthy SP, Byrn SR, Pinal R. J Phys Chem B. 2010 Jan 14;114(1):269-79. 

Curriculum Vitae

Click here for a full CV for Rodolfo Pinal. (an Adobe Acrobat file)

This record was last updated on Oct 30, 2014 at 8:45 AM
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