Department of Industrial and Physical Pharmacy Personnel - Gregory T. Knipp
Specialization: Characterization of membrane transporters, peptide-based drug delivery, placental and fetal fatty acid homeostasis, and PK/PDEducationBS Biochemistry, 1988, Cook College, Rutgers, The State University of New Jersey.MS Pharmaceutical Chemistry, 1995, The University of Kansas Ph.D., Pharmaceutical Chemistry, 1997, The University of Kansas Post-Doctoral Fellow, Department of Integrative and Molecular Physiology, The University of Kansas - Medical Center 1997-1999 Research: Characterization of membrane transporters, peptide-based drug delivery, placental and fetal fatty acid homeostasis, and PK/PDDr. Knipp researches the molecular and functional characterization of human intestinal oligopeptide transporters, the effect of xenobiotics on placental fatty acid homeostasis and fetal development, and the effects of processing induced dosage form variation on clinical performance in in vitro and in vivo models. Representative PublicationsY. Xu, Q. Wang, T.J. Cook, and G.T. Knipp, Placental fatty acid metabolism, J. Pharm. Sci. 96:2582-2606 (EPub June 4, 2007) (2007). A.S. Mathis, S. Jin, G.S. Friedman, F. Peng, S.M. Carl, and G.T. Knipp. The Pharmacodynamic Effects Sirolimus and Sirolimus-Calcineurin Inhibitor Combinations on Macrophage Scavenger and Nuclear Hormone Receptors. J. Pharm.Sci. 96:209-222 (2007; Epub, Oct. 9, 2006). Y. Xu, S. Agarwal, T.J. Cook, and G.T. Knipp. Di-(2-ethylhexyl)-Phthalate Affects Lipid Profiling in Fetal Rat Brain upon Maternal Exposure. Arch. Toxicol. 81:57-62 (2007; Epub, Sept 2, 2006). R.K. Bhardwaj, D.R. Herrera-Ruiz, N. Eltoukhy, M. Saad, and G.T. Knipp. The Functional Evaluation of Human Peptide/Histidine Transporter 1 (HPHT1) in Transiently Transfected COS-7 Cells. Eur. J. Pharm. Sci. 27:533-542 (2006). Y. Xu, T.J. Cook and G.T. Knipp. Methods for Investigating Placental Fatty Acid Transport. Methods Mol Med. 122:265-284 (2006). R.K. Bhardwaj, D. Herrera-Ruiz, P.J. Sinko, O.S. Gudmundsson, and G.T. Knipp. Delineation of HPEPT1 Meditated Uptake and Transport of Substrates with Varying Transporter Affinities Utilizing Stably Transfected HPEPT1/MDCK Clones and Caco-2 Cells. J. Pharmacol. Exp. Ther. 314:1093-1100 (2005). Q. Wang, D. Herrera-Ruiz, T.J. Cook, A.S. Mathis, R.K. Bhardwaj, and G.T. Knipp. Expression of Fatty Acid Transferring Proteins, PPAR and RXR Isoforms in the Rat and Human Gastrointestinal Tracts. J. Pharm. Sci. 94(2):363-372 (2005). D. Herrera, T.N. Faria, R.K. Bhardwaj. J. Timoszyk, R.L. Smith, D. Wall, O.S. Gudmundsson P. Moenech, and G.T. Knipp. A Novel hPEPT1 Stably Transfected Cell Line: Establishing a Correlation between Expression and Function. Mol. Pharm. 1(2):136-144 (2004). D.R. Herrera-Ruiz and G.T. Knipp. Current Perspectives on Established and Putative Mammalian Oligopeptide Transporters. J. Pharm. Sci. 92:691-714 (2003), Review. 25. D.R. Herrera-Ruiz, Q. Wang, O.S. Gudmundsson, T. Cook, R. Smith, T.N. Faria, and G.T. Knipp. Spatial Expression Patterns of Peptide Transporters in the Human and Rat Gastrointestinal Tracts, Caco-2 in vitro Cell Culture Model, and Multiple Human Tissues. AAPS PharmSci. 3(1):Article 9 (2001). Curriculum VitaeClick here for a full CV for Gregory T. Knipp. This record was last updated on May 5, 2009 at 9:48 AM |
