Faculty

Dr. Knipp's laboratory is dedicated to the utilization of new and improved models for assessing pharmaceutical performance.  The laboratory's research interests include  preclinical in vitro and in vivo ADMET screening, physicochemical characterization, early formulation development, and performing pharmacokinetic studies of new and traditional chemical entities.  

His laboratory has been recently focused on the development of a novel, direct contact human blood brain barrier triculture model for screening permeability-linked neuroactivity. Cultured in the presence of neurons, this flexible platform in vitro model has been applied to assess neurotoxicity and screening compounds with an observed neurotherapeutic/neurotoxic effect. This project is currently funded by the EPA. 

His laboratory has also been collaborating on two significant NIH funded projects: 1) an R01 on the development of novel antiviral compounds with the potential to treat Ebolavirus; and 2) a larger, multi-institutional U54 grant aimed at developing agents that may provide rapid rescue from cyanide exposure. 

Dr. Knipp also  currently serves as the faculty director of the Purdue Translational Pharmacology (PTP) CTSI Core Facility, where he  maintains a strong interest in the utilizing rodent and juvenile and adult porcine models for testing the pharmacokinetics formulations under stress free conditions. 

Faculty Director of the Purdue Translational Pharmacology (PTP) CTSI Core Facility

IPPH 45100 Industrial Practical Training

IPPH 58300  Advanced Biopharmaceutics

PHRM 828 Dosage Forms I

PHRM 866 Biotech/Advanced Parenteral Dosage Forms

RESEARCH AND TEACHING GRANTS:

Active 

May 2023-Apr. 2027 - Department of Defense, (Expansion Award), $824,400 (Purdue co-I; Bentley PI), “Preclinical Testing of a TRPV4 Antagonist for the Treatment of Hydrocephalus in a Porcine Model.”

Aug. 2020-July 2024 - Environmental Protection Agency, (PI) $790,441, OSAPE Star Grant, “Integrated Blood Brain Barrier-Computational Model Development to Predict Doses of Concern for Compound Linked Neurotoxicity.”

Aug. 2019-July 2024 - National Institute of Allergy and Infectious Diseases (R01 AI128364-01A1), (Co-PI; Davisson PI), “Antiviral Lead Identification to Treat Filovirus Infections.” 

July 2019 - June 2024 - National Institute of Neurological Disorders and Stroke-CounterACT Centers of Excellence (U54 NS079201-06A1), (Purdue Co-I; Davisson PI), “Discovery and Development of Novel Classes of Cyanide Countermeasure.”

Sept. 2010-Present - The Indiana Clinical Translational Sciences Institute, Faculty Director (Co-PI), “Establishment of the Purdue Porcine Translational Pharmacology Core.”

SELECTED PRESENTATIONS:

“Pediatric Formulation Development: The Utility of the Juvenile Porcine Model for Preclinical Pharmacokinetic Assessment” Presented at the 19^th Annual Congress of International Drug Discovery Science and Technology 2023 (IDDST 2023), Tokyo, Japan, May 8-10, 2023

“Challenges in the Preclinical Development of Pediatric Formulations: The Utilization of the Juvenile Porcine Model for PK/PD Evaluation.” Universidad Autónoma del Estado de Morelos, in Cuernavaca, Morelos, México. Hosted by Dea Herrera-Ruiz and the Facultad de Farmacia Commemorating the 25^th Anniversary of the College of Pharmacy. March 13-15, 2023.

P. Sluka, C.C. Zhang, and G.T. Knipp. “Coupled in vitro BBB triculture assay and computational model development to predict doses of concern for neurotoxicity.” Society of Toxicology 62^nd Annual Meeting and ToxExpo. Nashville, TN, March 2023.

Behymer, N. Fujii, V. Suresh, H. Mo, A. Chen, G.R. Boss, J. Lee, K. Saha, S. Mahon, M. Brenner, A.K. Nath, C.A. MacCrae, R.T. Peterson, G.T. Knipp and V.J. Davisson. “Intramuscularly Delivered Platinum-based Cyanide Countermeasures.” 2022 Globalization of Pharmacy Education Network (GPEN) Meeting. Organized by The University of Minnesota, Minneapolis, MN, October 2022.

Behymer, N. Fujii, V. Suresh, H. Mo, A. Chen, G.R. Boss, J. Lee, K. Saha, S. Mahon, M. Brenner, A.K. Nath, C.A. MacCrae, R.T. Peterson, G.T. Knipp and V.J. Davisson. “Optimization of Novel Platinum Based Cyanide Scavengers: In Vitro Prioritization.” 2022 AAPS PharmSci 360 Meeting. Boston, MA, October 2022.

M. Behymer,  H. Mo, N. Fujii, V. Suresh, A. Chen, J. Lee, A.K. Nath, K. Saha, S. Mahon, M. Brenner, C.A. MacCrae, R.T. Peterson, G.R. Boss, G.T. Knipp and V.J. Davisson. “Optimization of Novel Platinum-Based Cyanide Scavengers: In Vitro Prioritization.” The 15^th Annual CounterACT Network Research Symposium. New Orleans, LA, June 2022.

“Establishing a Physiologically Relevant In Vitro BBB Permeability and Neuroactivity Screening Model” Hosted by BioCrossroads, 2019 Life Sciences Summit, Indianapolis, IN, September 2019.

K. Lubin, M. Behymer, G.T. Knipp. “Design of Experiments Approach for the Optimization of a Physiologically Relevant In Vitro Blood Brain Barrier Model.” 22nd International Symposium on Signal Transduction at the Blood-Brain Barriers. Organized by Fraunhofer Inc., Wurzburg, Germany, September (2019).

K. Lubin, G.T. Knipp. Development and Optimization of a Direct Layered Contact Blood Brain Barrier Model for In Vitro Permeability Screening. World Preclinical Congress: Blood Brain Barrier, Boston, MA (2018).

C. Popescu, R.P. Gala, G.T. Knipp, R.R. McCain, and M.J. D’Souza. ODF (Oral Disintegrating Film) as a Pediatric Centric Delivery System. 9th European Paediatric Formulation Initiative Conference, Warsaw, Poland, September 19-21 (2017)

R.P. Gala, C. Popescu, G.T. Knipp, R.R. McCain, R.V. Ubale, R. Addo, T. Bhowmik, and M.J. D’Souza. Next Generation of Immunization: Oral Disintegrating Films Loaded with Nanoparticulate Measles Vaccine for Buccal Delivery. 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, U.K. (2016).

“Inert or Functional Pharmaceutical Excipients: Reviewing the Fundamental Basis for Risk in Pediatric and Adult Formulations” Hosted by Dr. Sophie-Dorothee Clas, 2016 M3 Conference: Molecules, Materials, Medicines, Solomons Island, MD. May 2016.

“Elucidating Peptide Permeation Pathways Across In Vitro Models of the Gastrointestinal Epithelial and Blood-Brain Barriers.” A Tribute to Ronald T. Borchardt, The University of Kansas, Lawrence, KS, October 2015

Mexican National Association of Farmacia, Hosted by Dr. Dea Herrera-Ruiz, "Treating Therapeutic Orphans: Preclinical Challenges to Pediatric Drug Development." 2015 Mexican National and International Congress of Pharmaceutical Sciences, Cancun, Quintana Roo, Mexico, September, 2015.

Eli Lilly Co., Indianapolis, IN. Hosted by Kaoutar Abbou Oucherif. “Risks and Challenges Associated with Pediatric Drug Development: What Role Should/Could Academia Play?” April 22, 2015.

R.P. Gala, C. Popescu, G.T. Knipp, R.R. McCain, R.V. Ubale, R. Addo, T. Bhowmik, and M.J. D’Souza. Needle less Measles Vaccine Delivery: Preclinical Evaluation of Oral Disintegrating Films in a Juvenile Pig Model. 2015 American Association of Pharmaceutical Scientists Annual Meeting, Orlando, FL. (2015).

“Pediatric Formulation and Regulatory Challenges: An Academic Perspective.” Presented at The Industry¹s Technical and Regulatory Path Forward for Pediatric Formulations Short Course, ExL Pharma’s 4^th Drug Formulation & Bioavailability: Breakthrough Techniques in Optimizing the Screening, Delivery, Solubility, and Stability of Drugs and Biologics to Enhance Product Life Cycles, Boston, MA, January 26, 2015.

“Solubility Enhancing Excipients Functional Effects on Drug Transporters and Metabolizing Enzymes: In Vitro Folklore or In Vivo Reality?” Presented in the AAPS Sunrise Session entitled: “The Excipient Paradox—Interaction of Solubilizing Excipients with Metabolizing Enzymes and Transporters.” 2014 American Association of Pharmaceutical Scientists Annual Meeting, San Diego, CA, November 5, 2014.

Development of Pediatric Formulations: Challenges and Opportunities. “Pediatric Clinical Pharmacology and Development: Assessing the Juvenile Swine as a Preclinical Animal PK Model.” 49^th AAPS Arden Conference, Rockville, MD. February 24-26, 2014.

https://www.ncbi.nlm.nih.gov/pubmed/?term=knipp+gt

Purdue PTP webpage:                                                                                                                 

V.S. Bebarta, X. Shi, S. Zhang, T.B. Hendry-Hofer, C.C. Severance, M.M. Behymer, G.R. Boss, S. Mahon, M. Brenner, G.T. Knipp, V.J. Davisson, R.T. Peterson, C.A. MacRae, J. Rutter, R.E. Gerszten, and A.K. Nath. Intramuscular Administration of Glyoxylate Rescues Swine from Lethal Cyanide Poisoning and Ameliorates the Biochemical Sequalae of Cyanide Intoxication. Toxicological Sciences. 35(11):1983-1996 (2022).

Behymer, H. Mo, N. Fujii, V. Suresh, A. Chen, J. Lee, A. Nath, K. Saha, S. Mahon, M. Brenner, C.A. MacCrae, R.T. Peterson, G.R. Boss, G.T. Knipp and V.J. Davisson. Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures. Chemical Research in Toxicology Nov 3; doi: 10.1093/toxsci/ (2022).

Wang, X. Yao, S. Toregrosa-Allen, B.D. Elzey, S. Utturkar, N.A. Lanman, V. Bernal-Crespo, M. Behymer, G.T. Knipp, Y. Yun, M.C. Veronesi, A.L. Sinn, K.E. Pollok, R.R. Brutkiewicz, K.S. Nevel, and S. Matosevic. Tumor-responsive, multifunctional CAR-NK cells cooperate with impaired autophagy to infiltrate and target glioblastoma. Proc. Nat. Acad. Sci. USA. 118(45):e2107507118 (2021).

K.E. Lubin and G.T. Knipp. Design of Experiment Based Optimization of an In Vitro Direct Contact Triculture Blood Brain Barrier Model for Permeability Screening. Pharm. Pharmacol. Int. J. 9(4):143-158 (2021).

D.J. Lindley, S.M. Carl, S. Mowery, W.J. Roth and G.T. Knipp. Evaluation of Human Peptide/Histidine Transporter 1 (hPHT1/SLC15A4) Function: Transport Kinetics Utilizing a HPHT1 shRNA Stably Transfected Knockdown in the hCMEC/D3 Blood-Brain Barrier Cell Line. Pharm. Pharmacol. Int. J. 9(3):109-118 (2021).

Lavan, X. Wang, R. McCain, A. Jannasch, B. Cooper, S. Hostetler, S. Byrn and G.T. Knipp. Development of a Pediatric Mini-Tablet Formulation for Expedited Preclinical Studies. AAPS PharmSciTech 22:40 (2021).

Z. Ding, G.T. Knipp, R.M. van Rijn, J.A. Chester, and V.J. Watts. The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice. Behav. Brain Res. 399(5):113051 (2021).

Book Chapter:  R.P. Gala, L. Bajaj, A. Bansal, K.B. Gomes, D. Joshi, I. Menon, R.U. Zaman, S.M. Zughaier, M. D’Souza, C. Popescu, N. D’Souza, G.T. Knipp, and M.J. D’Souza. Oral Vaccine Delivery: The Coming Age of Particulate Vaccines to Elicit Mucosal Immunity. In: Muttil P., Kunda N. (eds) Mucosal Delivery of Drugs and Biologics in Nanoparticles. AAPS Advances in the Pharmaceutical Sciences Series, Vol. 41. Springer, Cham, Switzerland.  pp 155-175 (2020).  

Lavan and G.T. Knipp. Considerations for Determining Direct Versus Indirect Functional Effects of Solubilizing Excipients on Drug Transporters for Enhancing Bioavailability. J. Pharm. Sci. 109(6):1833-1845 (2020).

M Lavan, SR Byrn, GT Knipp. Pediatric Formulations: Knowledge Gaps Limiting the Expedited Preclinical to Clinical Translation in Children. AAPS PharmSciTech 20(2):73, 2019.

J Morningstar, J Lee, T Hendry-Hofer, A Witeof, LT Lyle, G Knipp, et al. Intramuscular Administration of Hexachloroplatinate Reverses Cyanide-Induced Metabolic Derangements and Counteracts Severe Cyanide Poisoning. FASEB BioAdv 1(2):81-92, 2019.

 M Lavan, GT Knipp. Effects of Dendrimer-Like Biopolymers on Physical Stability of Amorphous Solid Dispersions and Drug Permeability across Caco-2 Cell Monolayers. AAPS PharmSciTech 19(6):2459-2471, 2018.

NH Sulimai, JC Ko, Y Jones-Hall, et al. Pharmacokinetic and Histopathological Evaluation of 25% Poloxamer as a Slow Release Carrier for Morphine in a Rat Model. Front. Vet. Sci. 5:Article 9, 2018.

C Kulczar, KL Lubin, S Lefebvre, DW Miller, GT Knipp.  Development of a Direct Contact Astrocyte-hCMEC/D3 Blood-Brain Barrier Coculture Model. J. Pharm. Pharmacol. 69(12):1684-1696, 2017.

LR Eichstadt, LA Corriveau, GE Moore, GT Knipp, et al. Absorption of Transdermal Fluoxetine Compounded in a Lipoderm Base Compared to Oral Fluoxetine in Client-Owned Cats. Int J Pharm Compd 21(3):242-246, 2017.

RP Gala, C Popescu, GT Knipp*, et al. Physicochemical and Preclinical Evaluation of a Novel Buccal Measles Vaccine. AAPS PharmSciTech 18(2):1-10, 2017.

Lavan, Monika; Byrn, Stephen R.; Knipp, G.T. Pediatric Formulations: Knowledge Gaps Limiting the Expedited Preclinical to Clinical Translation in Children, AAPS PharmSciTech (2019) 20(2):73 (EPub December 2018).

Morningstar, Jordan; Lee, Jangwoen; Hendry-Hofer, Tara; Witeof, Alyssa; Lyle, Tiffany; Knipp, Greg; McCrae, Calum A.; Boss, Gerry R.; Peterson, Randall T.; Davisson, Vincent J.; Gerszten, Robert E.; Bebarta, Vikhyat S.; Mahon, Sara; Brenner, Matt; Nath, Anjali K. Intramuscular Administration of Hexachloroplatinate Reverses Cyanide-Induced Metabolic Derangements and Counteracts Severe Cyanide Poisoning. FASEB BioAdv (Epub October 8, 2018; https://doi.org/10.1096/fba.1024).

Lavan, Monika; Knipp, Gregory T. Effects of Dendrimer-Like Biopolymers on Physical Stability of Amorphous Solid Dispersions and Drug Permeability across Caco-2 Cell Monolayers. AAPS PharmSciTech (2018) 19(6):2459-2471.

Sulimai, Nural H.; Ko, Jeff C.; Jones-Hall, Yava L.; Weng, Hsin-Yi; Deng, Meng; Breur, Gert J.; Knipp, Gregory T. Pharmacokinetic and Histopathological Evaluation of 25% Poloxamer as a Slow Release Carrier for Morphine in a Rat Model. Frontiers in Veterinary Science. (2018) 5: Article 9.

C. Kulczar, K.L. Lubin, S. Lefebvre, D.W. Miller, and G.T. Knipp.  Development of a Direct Contact Astrocyte-hCMEC/D3 Blood-Brain Barrier Coculture Model. J. Pharm. Pharmacol. 69(12):1684-1696 (2017).

L.R. Eichstadt, L.A. Corriveau, G.E. Moore, G.T. Knipp, B. Cooper, and W.E. Gwin. Absorption of Transdermal Fluoxetine Compounded in a Lipoderm Base Compared to Oral Fluoxetine in Client-Owned Cats. Int J Pharm Compd 21(3):242-246. (2017).

R.P. Gala, C. Popescu, G.T. Knipp*, R.R. McCain, R.V. Ubale, R. Addo, T. Bhowmik, C.D. Kulczar, and M.J. D’Souza*, Physicochemical and Preclinical Evaluation of a Novel Buccal Measles Vaccine. AAPS PharmSciTech [Pediatric Drug Development and Dosage Form Theme Issue] 18(2):1-10 (2017).

R.P. Gala, C. Popescu, G.T. Knipp*, R.R. McCain, R.V. Ubale, R. Addo, T. Bhowmik, C.D. Kulczar, and M.J. D’Souza*, Physicochemical and Preclinical Evaluation of a Novel Buccal Measles Vaccine. AAPS PharmSciTech [Pediatric Drug Development and Dosage Form Theme Issue] 1-10 (EPub June 29, 2016; Shared: https://rdcu.be/ndT7).

J. Kim, Y.L. Jones, R. Wei, J. Myers, Y. Qi, G.T. Knipp, and W. Liu. Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents. Front. Genetics. 4 (Article 162):1-6 (2013).

W.J. Roth, C.B. Kissinger, R.R. McCain, B.R. Cooper, J.N. Marchant-Forde, R.C. Vreeman, S. Hannou, and G.T. Knipp.  Assessment of Juvenile Pigs to Serve as Human Pediatric Surrogates for Preclinical Formulation Pharmacokinetic Testing. AAPS J. [Theme Issue: Challenges and Opportunities in Pediatric Drug Development] 15 (3):763-774 (2013; EPub: April 18, 2013).

Editorial: Perspectives on Pediatric Drug Development. Roth, WJ, Sage, DP, Kulczar, C, Liu, W, and Knipp, GT. Revista Mexicana De Ciencias Farmaceuticas 2012; 43 (3):5-6.

Comparative Pharmacokinetic Studies of Immediate and Modified Release Formulations of Glipizide in Pigs and Dogs. Kulkarni, R, Yumibe, N, Wang, Z, Zhang, X, Tang, CC, Ruterbories, K, Cox, A, McCain, R, and Knipp, GT. J. Pharm. Sci. 2012; 101 (11): 4327-4336, 2012. Epub 19 August 2012. 

The Effects of Intra-Laboratory Modifications to Media Composition and Cell Source on the Expression of Pharmaceutically Relevant Transporters and Metabolizing Genes in the Caco-2 Cell Line. Roth WJ, Lindley, DJ, Carl, SM, and Knipp, GT.  J. Pharm. Sci. 11 July 2012; 101 (10): 3962-3978. Epub 11 July 2012. 

The Effects of Media on Pharmaceutically Relevant Transporters in the Human HT-29 Adenocarcinoma Cell Line: Does Culture Media Need to be Controlled? Lindley, DJ, Roth, WJ, Carl, SM, and Knipp, GT. J. Pharm. Sci. 2012; 101 (4): 1616-1630.

Plasma Cortisol and Noradrenalin Concentrations in Pigs: Automated Sampling of Freely Moving Pigs Housed in the PigTurn^® Versus Manually Sampled and Restrained Pigs. Marchant-Forde, JN, Matthews, DL, Poletto, R, McCain, RR, Mann, DD, McGraw, RT,  Hampsch, J, Peters, S, Knipp, GT, and Kissinger, CB. Anim. Welfare 2012; 21: 197-205.

Assessing the Performance of Amorphous Solid Dispersions. Newman, A, Knipp, G, and Zografi, G. J. Pharm. Sci. 2012: 101: 1355–1377.

Summary of the national institute of child health and human development-best pharmaceuticals for children act pediatric formulation initiatives workshop-pediatric biopharmaceutics classification system working group. Abdel-Rahman SM, Amidon GL, Kaul A, Lukacova V, Vinks AA, Knipp GT.  Members of the BCS Task Force. Clin Ther. 2012 Nov;34(11):S11-24. doi:10.1016/j.clinthera.2012.09.014.

"ABC and SLC Transporter Expression and Proton Oligopeptide Transporter (POT) Mediated Permeation across the Human Blood-Brain Barrier Cell Line, hCMEC/D3". Carl SM, Lindley DJ, Das D, Couraud PO, Weksler BB, Romero I, Mowery SA, Knipp GT. Mol Pharm. 2012 Nov 6. [Epub ahead of print] No abstract available.

The Evaluation of Peptide/Histidine Transporter 1 (PHT1) Function: Uptake Kinetics Utilizing a COS-7 Stably Transfected Cell Line.  Lindley DJ, Carl SM, Mowery S, Knipp GT. Revista Mexicana De Ciencia Farmaceuticas, octubre-diciembre 2011; 42(4);57-65.

ABC and SLC transporter expression and pot substrate characterization across the human CMEC/D3 blood-brain barrier cell line. Carl SM, Lindley DJ, Couraud PO, Weksler BB, Romero I, Mowery SA, Knipp GT. Mol Pharm. 2010 Aug 2;7(4):1057-68.

The effects of excipients on transporter mediated absorption. Goole J, Lindley DJ, Roth W, Carl SM, Amighi K, Kauffmann JM, Knipp GT. Int J Pharm. 2010 Jun 30;393(1-2):17-31. Epub 2010 Apr 24. 

Book Chapters:

Invited Chapters

1.    D.J. Lindley, S.M. Carl, D.R. Herrera-Ruiz, L.-F. Pan, L.B. Ward, J.M.E. Goole, O.S. Gudmundsson, and G.T. Knipp. Chapter 18: Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide Based Pharmaceuticals. In Oral Bioavailability: Basic Principles, Advanced Concepts and Application. Eds. M. Hu and X. Li. In the Wiley Series on Drug Discovery and Development, Series Ed. B. Wang, John Wiley & Sons, New York, NY. pp. 291-308 (2011).

2.   S.M. Carl, D.J. Lindley, G.T. Knipp, K.R. Morris, E. Oliver, G.W. Becker and R.A. Arnold. Biotechnology Drug Product Development. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 1-32 (2008). [DOI: 10.1002/9780470259818.ch1; Republished in a Wiley Special Edition Series “Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing.” DOI: 10.1002/9780470571224.pse340 1-26 (2010)]

3.   E. Oliver, S.M. Carl, K.R. Morris, G.W. Becker and G.T. Knipp. Regulatory Considerations in the Approval of Follow-On Protein Drug Products. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 33-57 (2008). [DOI: 10.1002/9780470259818.ch2; Republished in a Wiley Special Edition Series entitled “Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing.” 1–32 (2010)] 

4.    S.M. Carl, D.J. Lindley, G.T. Knipp, K.R. Morris, E. Oliver, G.W. Becker and R.A. Arnold, Biotechnology Drug Product Development. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 1-32 (2008).

5.    E. Oliver, S.M. Carl, K.R. Morris, G.W. Becker and G.T. Knipp. Regulatory Considerations in the Approval of Follow On Protein Drug Products. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 33-57 (2008).

6.    R.K. Bhardwaj, D.R. Herrera-Ruiz, Y. Xu, S.M. Carl, T.J. Cook, N. Vorsa, and G.T. Knipp. Chapter 7: Intestinal Transporters in Drug Absorption. In Biopharmaceutics Applications in Drug Development. Editors R. Krishna and L. Yu, Kluwer Press, NY, pp. 175-261 (2008).

Edited Textbook Chapters

Martin’s Physical Pharmacy and Pharmaceutical Sciences, Fifth Edition. Editor Patrick J. Sinko. Lippincott, Williams & Wilkins, Baltimore, MD, (2006).

1.    G.T. Knipp and K.R. Morris, Chapter 2: States of Matter.

2.    H. Morelos, D. Herrera-Ruiz, and G.T. Knipp, Chapter 3: Thermodynamics.

3.    G.T. Knipp, H. Morelos and D. Herrera-Ruiz, Chapter 4: Physical Properties of Drug Molecules.

Refereed Abstracts 

1. N. Yumibe, R. Kulkarni, Z. Wang, X. Zhang, K. Ruterbories, A. Cox, R. Ajamie, C.C. Tang, G. Knipp, Robin McCain. Comparative Pharmacokinetic Studies of Immediate and Modified Release Formulations of Glipizide in Pigs and Dogs. 2011 AAPS Indiana/Ohio Discussion Group-Pharma Industry Challenges/Perspectives Symposium, Indianapolis, IN. (2011).
2. W.J. Roth, C.B. Kissinger, S. Hannou, B.R. Cooper, R.R. McCain,  R. Vreeman, and G.T. Knipp. Development and Testing of Novel Pediatric Formulation of Rifampicin for the Treatment of Tuberculosis (TB) in Infants and Young Children. 2011 AAPS Indiana/Ohio Discussion Group-Pharma Industry Challenges/Perspectives Symposium, Indianapolis, IN. (2011). Best Poster Award