Garnet E. Peck, Ph.D. Professor Emeritus Phone: (765) 494-1400 Fax: (765) 494-6545 E-mail: gpeck30@verizon.net Full directory listing

Research

A major research interest is controlling drug delivery of solid drug products. This research includes the coating of either fine particles or the addition of active ingredients onto beads and further coating for the purpose of controlled drug delivery. Studies are concerned with the use of both new and existing polymer substances. To evaluate these systems, it is necessary to determine the surface characteristics of all solids involved. In this laboratory we also are involved with the use of matrix systems in tablet form for the purpose of controlled drug delivery. Further, we are involved with controlled release membranes, in particular those membranes formed by polysiloxane latex dispersions.

An area of continued research involves the preparation of solid agglomerates by either the wet technique or by dry procedures involving roller compaction. We are studying the fundamentals of agglomeration, especially the mechanism of agglomeration, through the use of instrument mixing devices, in an attempt to understand and optimize these operations. The role of binders continues to be an important element in these studies.

The role and effect of various ingredients in tablet dosage forms are under study. This involves not only the tablet matrix itself, but also the various processing variables associated with the application of coating materials as they affect the resultant drug product quality. This research requires the evaluation of each process variable, especially when attempting to define those variables that need to be optimized. Ongoing studies are involved with the evaluation of newer polymeric substances for the preparation of suitable coating membranes for either delayed or controlled drug release. Endpoint determination of solid blending and blender design using innovative detection probes is a current research area of high priority.